GenomeNet

Database: UniProt
Entry: H2UHA1_TAKRU
LinkDB: H2UHA1_TAKRU
Original site: H2UHA1_TAKRU 
ID   H2UHA1_TAKRU            Unreviewed;      4953 AA.
AC   H2UHA1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 38.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000036322};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000036322};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036322, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036322}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036322}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000036322}.
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DR   Ensembl; ENSTRUT00000036453; ENSTRUP00000036322; ENSTRUG00000014204.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4494   4514       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4728       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4832   4853       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      599    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1284   1511       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4004   4030       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4953 AA;  560308 MW;  8B67AC90BD71BB77 CRC64;
     AACDSPGYDP VSLLKQDDEV VLQCVACIQK ENRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICTFVLE QSLSVRALQE MLANSGQNSE GAAQSGGHKT LLYGHAILLR HSFSSMYLAC
     LKTSRSQTDK LSFDVGLQED STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSLSSERYL
     HLSISNGNIQ VDASFMQTLW NVHPICSGSN VEEGYLLGGH VIRLFHGHDE VVAIPGSDQS
     EEEQRIVNYE TGKAGAKARS LWRLEPLRIS WSGSHIRWGQ PFRLRHLTTG HYLALTDDRG
     LVLQDRERSD TDATAFCFRA SKKQEKLEQS PKRDIEGMGV AEIKYGDSLC FIMHVATGLW
     LSYQAPDVKS ARLGPLKRRA CLHTEGHMDD GLTLQRCQHE ESRAARIIRN TTLLFNRFVR
     DLDCLGVKNR LVVFLPVEEV LQTLNDLIAY FQLPDVELEH EERQIKLRSL KNRQNLFKQE
     GMLNLVSNCI DRLNVYNSAA HFGECAGQEA GAAWKDILNL LYELLAALIR GNRNNCTQFS
     NNLDWLVSKL ERLESSSGIL EVLHCILIES PEALNIIQRG HIKSIISLLY KHGRNHKILD
     VLCSLCVCNG VAVRTNQNLI CDHLLPKRDL LLQSQLVNVV QSMRPNIFLG VSEGSAQYKK
     WYYELMIDQV DHFVTSEPTH LRVGWANTKG YAPYPGGGEG WGGNGVGDDL YSFGFDGLHL
     WSGRVPRAAA SLNQHILTSE DVVSCCLDLG APSISFRING QPVQGMFENF NADGLFFPVA
     SFSAGVKVRF LLGGRHGDFK FLPPSGYAPC YEALLPKEKM KVEPVKEYKR DVAGVRDLLG
     TAQLLSQASF IPTPVETSQI IMPPHLEKVR DKLAENIHEL WGMNKIELGW TYGKIRDDNK
     RQHPCLVDFS KLPETEKNYN LQMSTETLKT LLALGCRVVQ VNPNAENSLK KIKLTKNYMM
     SNGYKPSPLD LSDIKLTPGQ ELLVDKLAEN AHNVWAKDRI KQGWTYGIQQ DLKSKRNPRL
     VPYVLLDERT KKSNRDSLRE AIRTLIGYGY NIEPSDQEGE FPPESGQTVE RISVDKVRFF
     RVERTYAVKT GKWYFEFEAV TGGDMRVGWA RPACKPDVEL GTDAHAFVFD GYRGHCLHTG
     GRLFGRCWHA GDVVGCMINM QDKSMIFTLN GEILITTKGS ELCFTDFDTE DGFIPVCSLG
     LAQVGRMNLG KDASTFKYYT MCGLQEGFEP FAVNMNREVT MWFSKRLPTF VNVPKDHNHI
     AVTRIDGTID SPPCLKVSHK TFGSQNSNAD MVLCRLSMPI EFHSVFKSSP IADVNGIHEE
     DVLKVKHRYS SSHFTHARPE INNTVPCRYP LRSVRHSDES RRVDYSNITT YYHSVRVFAG
     QDPAGVWVGW VTPDYHYYSN NFNLGKNRTV TVTLGDERGR VHERDSVKRS NCYMVWGGDA
     TSAAHASSRS NVDLEIGCLI DLATGLVTFT INGKEISTSY QVEPNTKLFP AVFVRPTSAN
     LFQFELGKIK NAMPLSSATF KSEHKNPVPQ CPPRLDVQTI SAVLWSRMPN NFLKVDTARV
     SERHGWVVQC VEPLQMLAVH IPEENRCVDI MELSEQEDLR KFHYHTLKLY CALCALGNTR
     VAHALCSHLD QSQLLYTIDN QYLSGMLREG CYNVLISIHL ETAKEARLMM KDEFIIPVTP
     ETRSIRLFFD ATKKHRPPGV GLSTSLKPRF NFAPPCFIST KQEQHLYSPQ VPLDTLKEKA
     ISMLTEAVQG GGHHIRDPVG GCVEYQFVPI LKLISTLLTM GVLASEDVHQ ILLLIDPNVF
     RETREEGNSG ATDKEGLAGA VDKAVEAGEE EAAKEAKQPL KGLLEKRLPE PVKRQMCELL
     HYFCDCELKH RIEAIVSFSD NFVSKLQFNQ KYRYNELMLA LNMSAAVTAK KTKEFRSPPQ
     EQINMLLTFS TGDDCPCPSD IQEELYDFHN QLQLHCGIPM EEDQDEHYTS IRGRLLMLVN
     KIKGQAHKSE EPSEKEQAAP SNLKELISQT MVSWAQECHI QDPQLVRKMF SLLRRQYDSI
     GELLRAMRKT YTISASSVQD TINLLASLGQ IRSLLSVRMG KEEEKLMIDG LGDIMNNKVF
     YQHPNLMRIL GMHETVMEVM VNVLGGDKSQ EIAFPKMVAS CCRFLCYFCR ISRQNQKAMF
     DHLSYLLENS SVGLASPSMR GSTPLDVAAS SVMDNNGLAL ALEEPDLEKV VTYLAGCGLQ
     SCPMLLAKGY PDIGWNPIEG ERYLSFLRFA VFVNGESVEE NSSVVVKLLI RRPECFGPAL
     RGEGGNGLLA AMKEAIKISE TPALDLPGSV HGVCSDVSAD GDDEEEVVHM GNAIMSFYSA
     LIDLLGRCAP EMHLINKGKG EALRIRAILR SLVPTEDLVG IISIPLKMPI INKDGSVTEP
     DMSASFCPDH KAPMVLFLDR VYGIEDQSFL LHLLEVGFLP DLRAATSLDT EGLCTTETAL
     AMNRYIGSAL LPLLTRCAPL FAGTEHYASL IDSTLHTIYR LSKGRSLTKA QRDAIEECLL
     AVCKHLRPSM LQQLLRRLVF DVPLLSEYCK MPLRLLTNHY EQNWKYYCLP SGWGSYGTAS
     EDELLLTKKL FWGIFDSLSQ RKYDPELFKM AMPCLSAIAG ALPPDYVDAS ISTAVEKPVS
     VDAQGNFDPK PINTANVSLP EKLEHFANKY GEHLHEKWSA EKVLLGWKYG DSVDEKAKIH
     PQLRTYKSLT EKEKEIYRWP IRETLKSMLA MGWSIDRTKD GESMSQQRES EKMRKISQVS
     QVNSQANGFN PSPTDTSNVV LSRELQGMVE VVAENYHNIW AKKKKSDLGS RVKGGGPHPL
     LVPYDTLTAR EKARDREKAQ DLFRFLQING YSITRGLKDL EQDSSSMEKR FAYKFLKKLL
     KYVDQAQEFI AHLALAVEAM AASGKTDRSP HEQEIKFFAK VLLPLIDQYF KNHCLYFLSS
     PNKNLSSSGY ASNKEKEMVT SLFCKLAALV RHRISLFGSD STTIVSCLHI LAHTLDTRTV
     MKSGSELVRL GLRTFFENAA EDLEKTFENL KLGKFTHSRS QMKGVSQNIN YTTVALLPIL
     TALFEHITQH HFGVDLLLED VQVSCYRILT SLYALGTGKN IYVERQLPAL GQCLATLAGA
     MPVAFLEPLL NTYNPCSVFN TKSARERAIL GIPGSVEEMC PGMPRLDGLM KDINDMAESG
     ARYTEMPHVI EVVLPMLCNY LSYWWEKGPE NPLSSGGSVC CTTVTSEHLS VILGNILKIL
     NNNLGIDEAS WMKRIAVYVQ PIISKARADL LRSHFLPTLE KLKKKTVKVV SEEELLKADG
     RGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSRW LKEPDADSNE LFRMVAEIFI
     LWCKSHNFKR EEQNFVVQNE INNLSFLTGD NKTKMSKSFK EKSGGQDQER RHKKRRGEFY
     SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKTRYLLK DTDEEVKDHI QQNLHLREKS
     EDPAVRWQLN LYRDRALRFE GPPDPEKVLD RIQRISAAVF NLEQVEQPLR SKKCVWQKLL
     SKQRKRAVVA CFRMAPLYNL PRHRSINLFL QAYQRIWIET EEYSFEEKLV QDLAKTQPKM
     EEEEEEEVKK QPDPLHQLIL HFSHNALTEC SSLEEDPLYI AYADMMAKSC AEGEEEEEVP
     VPMQEKEMEK QKMLYQQARL HDRGAAEMVL QMISASKGRL GAMVTVTLKL GISILNGGNI
     LVQQKMLDYL KEKRDVGFFK SLSGLMMSCS VLDLNAFERQ NKAEGLGMVT EEGSNHVFYL
     IGRSQRSKVL QDDEFTKDLF RFLQLLCEGH NNDFQNFLRT QTGNTTTVNI IISTVDYLLR
     LQESISDFYW YYSGKDVIDE AGQRNFSRAL AVAKQVFNSL TEYIQGPCVG NQQSLAHSRL
     WDAVVGFLHV FANMQMKLSQ IYGMPNEGSR EGDSSQIELL KELLDLQQDM VVMMLSLLEG
     NVVNGTIGKQ MVDTLVESSS NVEMILKFFD MFLKLKDLTT SDSFKEYDPE NKGVISKKDF
     QKSMENQKQY SQSEIEFLLS CAEADENDMF NYKQFVDRFH EPAKDIGFNV AVLLTNLSEH
     MPHDARLSTF LDLAESVLSY FEPYLGRIEI MGGAKRIERV YFEISESSRT QWEKPQVKES
     KRQFIFDVVN ERGESEKMEL FVNFCEDTIF EMQLASQISE PDPVERSRGR RGRQPERAGK
     PGRGRGGERA AGVVLAFTVA CISMRKSLCH FRQLLTLRSI RRQYRTFRKM TVREMVQGFF
     SFFWIIITGF LHFFYSLVWG FFHILWTTMF GGGFVEGAKN MKVTDILGNM PDPTQFGIHG
     DVLELEKIEA NEASALAEIG QMSQGDAAEA DLMAELLNIH PRNQGKHGSE PGLGDVSEMV
     VGDAPSIASA VKQKKAEVSN LLNALAPQMA AKKTASNGEH KSDSEKADLE DGEKNDHAKT
     KDNAPQGSSV GEKKAPKKRP GQKKEPPEAF MASFLASVEI YQTKILNYLA RNFYNLRFLA
     LFVAFAINFI LLFYKVTGDY SDDEDPWNGR RRSGEEEEEG ALEYFILQES TGYMAPALRC
     LAILHTIISF LCVVGYYYLK VPLVVFKREK EIARKLEFAG LYITEQPSDD DIKGQWDRLV
     INTPSFPNNY WDKFVKRKVI KKYGDLYGAE RIAELLGLDK SALDFNPTEE TVTKEASLVS
     WLSSIDTKYH VWKMGVVFTD NSFLYLVWYT TMSILGHYNN FFFAAHLLDI AMGFKTLRTI
     LSSVTHNGKQ LVLTVGLLAV VVYLYTVVAF NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH
     MYVGVRAGGG IGDEIEDPAG DPYELYRILF DITFFFFVIV ILLAIIQVAG LIIDAFGELR
     DQQEQVKEDM ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY LINKDETEHT
     GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
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