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Database: UniProt
Entry: H2UHA4_TAKRU
LinkDB: H2UHA4_TAKRU
Original site: H2UHA4_TAKRU 
ID   H2UHA4_TAKRU            Unreviewed;      4949 AA.
AC   H2UHA4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-DEC-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000036325};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000036325};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036325, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036325}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000036325}.
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DR   Ensembl; ENSTRUT00000036456; ENSTRUP00000036325; ENSTRUG00000014204.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4474   4492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4553   4575       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4702   4726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4747   4769       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4828   4849       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       95    150       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      157    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    264       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      337    394       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      596    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1010   1205       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3993   4019       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3459   3479       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4949 AA;  559723 MW;  73575CF9A208D8B6 CRC64;
     DSPGYDPVSL LKQDDEVVLQ CVACIQKENR KFCLAAEGLG NRLCYLEPTS EAKYVPPDLC
     ICTFVLEQSL SVRALQEMLA NSGQNSVKAA QSGGHKTLLY GHAILLRHSF SSMYLACLKT
     SRSQTDKLSF DVGLQEDSTG EACWWTIHPA SKQRSEGEKV RIGDDLILVS LSSERYLHLS
     ISNGNIQVDA SFMQTLWNVH PICSGSNVEE GYLLGGHVIR LFHGHDEVVA IPGSDQSEEE
     QRIVNYETGK AGAKARSLWR LEPLRISWSG SHIRWGQPFR LRHLTTGHYL ALTDDRGLVL
     QDRERSDTDA TAFCFRASKK QEKLEQSPKR DIEGMGVAEI KYGDSLCFIM HVATGLWLSY
     QAPDVKSARL GPLKRRACLH TEGHMDDGLT LQRCQHEESR AARIIRNTTL LFNRFVRDLD
     CLGVKNRLVV FLPVEEVLQT LNDLIAYFQL PDVELEHEER QIKLRSLKNR QNLFKQEGML
     NLVSNCIDRL NVYNSAAHFG ECAGQEAGAA WKDILNLLYE LLAALIRGNR NNCTQFSNNL
     DWLVSKLERL ESSSGILEVL HCILIESPEA LNIIQRGHIK SIISLLYKHG RNHKILDVLC
     SLCVCNGVAV RTNQNLICDH LLPKRDLLLQ SQLVNVVQSM RPNIFLGVSE GSAQYKKWYY
     ELMIDQVDHF VTSEPTHLRV GWANTKGYAP YPGGGEGWGG NGVGDDLYSF GFDGLHLWSG
     RVPRAAASLN QHILTSEDVV SCCLDLGAPS ISFRINGQPV QGMFENFNAD GLFFPVASFS
     AGVKVRFLLG GRHGDFKFLP PSGYAPCYEA LLPKEKMKVE PVKEYKRDVA GVRDLLGTAQ
     LLSQASFIPT PVETSQIIMP PHLEKVRDKL AENIHELWGM NKIELGWTYG KIRDDNKRQH
     PCLVDFSKLP ETEKNYNLQM STETLKTLLA LGCRVVQVNP NAENSLKKIK LTKNYMMSNG
     YKPSPLDLSD IKLTPGQELL VDKLAENAHN VWAKDRIKQG WTYGIQQDLK SKRNPRLVPY
     VLLDERTKKS NRDSLREAIR TLIGYGYNIE PSDQEGGQTV ERISVDKVRF FRVERTYAVK
     TGKWYFEFEA VTGGDMRVGW ARPACKPDVE LGTDAHAFVF DGYRGHCLHT GGRLFGRCWH
     AGDVVGCMIN MQDKSMIFTL NGEILITTKG SELCFTDFDT EDGFIPVCSL GLAQVGRMNL
     GKDASTFKYY TMCGLQEGFE PFAVNMNREV TMWFSKRLPT FVNVPKDHNH IAVTRIDGTI
     DSPPCLKVSH KTFGSQNSNA DMVLCRLSMP IEFHSVFKSS PIADVNGIHE EDVLKVKHRY
     SSSHFTHGRL ICCTPEINNT VPCRYPLRSV RHSDESRRVD YSNITTYYHS VRVFAGQDPA
     GVWVGWVTPD YHYYSNNFNL GKNRTVTVTL GDERGRVHER DSVKRSNCYM VWGGDATSAA
     HASSRSNVDL EIGCLIDLAT GLVTFTINGK EISTSYQVEP NTKLFPAVFV RPTSANLFQF
     ELGKIKNAMP LSSATFKSEH KNPVPQCPPR LDVQTISAVL WSRMPNNFLK VDTARVSERH
     GWVVQCVEPL QMLAVHIPEE NRCVDIMELS EQEDLRKFHY HTLKLYCALC ALGNTRVAHA
     LCSHLDQSQL LYTIDNQYLS GMLREGCYNV LISIHLETAK EARLMMKDEF IIPVTPETRS
     IRLFFDATKK HRPPGVGLST SLKPRFNFAP PCFISTKQEQ HLYSPQVPLD TLKEKAISML
     TEAVQGGGHH IRDPVGGCVE YQFVPILKLI STLLTMGVLA SEDVHQILLL IDPNVFRETR
     EEGNSGATDK EGLAGAVDKA VEAGEEEAAK EAKQPLKGLL EKRLPEPVKR QMCELLHYFC
     DCELKHRIEA IVSFSDNFVS KLQFNQKYRY NELMLALNMS AAVTAKKTKE FRSPPQEQIN
     MLLTFSTGDD CPCPSDIQEE LYDFHNQLQL HCGIPMEEDQ DEHYTSIRGR LLMLVNKIKG
     QAHKSEEPSE KEQAAPSSSP ANLKELISQT MVSWAQECHI QDPQLVRKMF SLLRRQYDSI
     GELLRAMRKT YTISASSVQD TINLLASLGQ IRSLLSVRMG KEEEKLMIDG LGDIMNNKVF
     YQHPNLMRIL GMHETVMEVM VNVLGGDKSQ EIAFPKMVAS CCRFLCYFCR ISRQNQKAMF
     DHLSYLLENS SVGLASPSMR GSTPLDVAAS SVMDNNGLAL ALEEPDLEKV VTYLAGCGLQ
     SCPMLLAKGY PDIGWNPIEG ERYLSFLRFA VFVNGESVEE NSSVVVKLLI RRPECFGPAL
     RGEGGNGLLA AMKEAIKISE TPALDLPGSV HGVCSDVSAD GDDEEEVVHM GNAIMSFYSA
     LIDLLGRCAP EMHLINKGKG EALRIRAILR SLVPTEDLVG IISIPLKMPI INKDGSVTEP
     DMSASFCPDH KAPMVLFLDR VYGIEDQSFL LHLLEVGFLP DLRAATSLDT EGLCTTETAL
     AMNRYIGSAL LPLLTRCAPL FAGTEHYASL IDSTLHTIYR LSKGRSLTKA QRDAIEECLL
     AVCKHLRPSM LQQLLRRLVF DVPLLSEYCK MPLRLLTNHY EQNWKYYCLP SGWGSYGTAS
     EDELLLTKKL FWGIFDSLSQ RKYDPELFKM AMPCLSAIAG ALPPDYVDAS ISTAVEKPVS
     VDAQGNFDPK PINTANVSLP EKLEHFANKY GEHLHEKWSA EKVLLGWKYG DSVDEKAKIH
     PQLRTYKSLT EKEKEIYRWP IRETLKSMLA MGWSIDRTKD GESMSQQRES EKMRKISQVS
     QVNSQANGFN PSPTDTSNVV LSRELQGMVE VVAENYHNIW AKKKKSDLGS RVKGGGPHPL
     LVPYDTLTAR EKARDREKAQ DLFRFLQING YSITRGLKDL EQDSSSMEKR FAYKFLKKLL
     KYVDQAQEFI AHLALAVEAM AASGKTDRSP HEQEIKFFAK VLLPLIDQYF KNHCLYFLSS
     PNKNLSSSGY ASNKEKEMVT SLFCKLAALV RHRISLFGSD STTIVSCLHI LAHTLDTRTV
     MKSGSELVRL GLRTFFENAA EDLEKTFENL KLGKFTHSRS QMKGVSQNIN YTTVALLPIL
     TALFEHITQH HFGVDLLLED VQVSCYRILT SLYALGTGKN IYVERQLPAL GQCLATLAGA
     MPVAFLEPLL NTYNPCSVFN TKSARERAIL GIPGSVEEMC PGMPRLDGLM KDINDMAESG
     ARYTEMPHVI EVVLPMLCNY LSYWWEKGPE NPLSSGGSVC CTTVTSEHLS VILGNILKIL
     NNNLGIDEAS WMKRIAVYVQ PIISKARADL LRSHFLPTLE KLKKKTVKVV SEEELLKADG
     RGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSRW LKEPDADSNE LFRMVAEIFI
     LWCKSHNFKR EEQNFVVQNE INNLSFLTGD NKTKMSKSIS VQSGGQDQER RHKKRRGEFY
     SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKTRYLLK DTDEEVKDHI QQNLHLREKS
     EDPAVRWQLN LYRDRALRFE GPPDPEKVLD RIQRISAAVF NLEQVEQPLR SKKCVWQKLL
     SKQRKRAVVA CFRMAPLYNL PRHRSINLFL QAYQRIWIET EEYSFEEKLV QDLAKTQPKM
     EEEEEEEVKK QPDPLHQLIL HFSHNALTEC SSLEEDPLYI AYADMMAKSC AEGEEEEEGK
     EKTFEEKEME KQKMLYQQAR LHDRGAAEMV LQMISASKGR LGAMVTVTLK LGISILNGGN
     ILVQQKMLDY LKEKRDVGFF KSLSGLMMSC SVLDLNAFER QNKAEGLGMV TEEGSNHVFY
     LIGRSQRSKV LQDDEFTKDL FRFLQLLCEG HNNDFQNFLR TQTGNTTTVN IIISTVDYLL
     RLQESISDFY WYYSGKDVID EAGQRNFSRA LAVAKQVFNS LTEYIQGPCV GNQQSLAHSR
     LWDAVVGFLH VFANMQMKLS QDSSQIELLK ELLDLQQDMV VMMLSLLEGN VVNGTIGKQM
     VDTLVESSSN VEMILKFFDM FLKLKDLTTS DSFKEYDPEN KGVISKKDFQ KSMENQKQYS
     QSEIEFLLSC AEADENDMFN YKQFVDRFHE PAKDIGFNVA VLLTNLSEHM PHDARLSTFL
     DLAESVLSYF EPYLGRIEIM GGAKRIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE
     RGESEKMELF VNFCEDTIFE MQLASQISEP DPVERSRGRR GRQPERAGKP GRGRGGERAA
     GVVLAFTVAC ISMRKSLCHF RQLLTLRSIR RQYRTFRKMT VREMVQGFFS FFWIIITGFL
     HFFYSLVWGF FHILWTTMFG GGFVEGAKNM KVTDILGNMP DPTQFGIHGD VLELEKIEAN
     EASALAEIGQ MSQGDAAEAD LMAELLNIHP RNQGKHGSEP GLGDVSEMVV GDAPSIASAV
     KQKKAEMAAK KTASNGEHKS DSEKADLEDG EKNDHAKTKD NAPQGSSVGE KKAPKKRPGQ
     KKEPPEAFMA SFLASVEIYQ TKILNYLARN FYNLRFLALF VAFAINFILL FYKIAAAALG
     RHGGDAFLPF QVTGDYSDDE DPWNGRRRSG EEEEEGALEY FILQESTGYM APALRCLAIL
     HTIISFLCVV GYYYLKVPLV VFKREKEIAR KLEFAGLYIT EQPSDDDIKG QWDRLVINTP
     SFPNNYWDKF VKRKVIKKYG DLYGAERIAE LLGLDKSALD FNPTEETVTK EASLVSWLSS
     IDTKYHVWKM GVVFTDNSFL YLVWYTTMSI LGHYNNFFFA AHLLDIAMGF KTLRTILSSV
     THNGKQLVLT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED EPDMKCDDMM TCYLFHMYVG
     VRAGGGIGDE IEDPAGDPYE LYRILFDITF FFFVIVILLA IIQVAGLIID AFGELRDQQE
     QVKEDMETKC FICGIGNDYF DTTPHGFETH TLQEHNLANY LFFLMYLINK DETEHTGQES
     YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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