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Database: UniProt
Entry: H2UHA5_TAKRU
LinkDB: H2UHA5_TAKRU
Original site: H2UHA5_TAKRU 
ID   H2UHA5_TAKRU            Unreviewed;      4944 AA.
AC   H2UHA5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000036326};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000036326};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036326, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036326}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000036326}.
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DR   Ensembl; ENSTRUT00000036457; ENSTRUP00000036326; ENSTRUG00000014204.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4485   4505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4547   4570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4694   4719       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4742   4764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4823   4844       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      107    162       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    214       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      222    276       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      282    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      349    406       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      608    806       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1022   1221       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1321   1536       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4006   4032       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4944 AA;  559934 MW;  BF65EECE966A160D CRC64;
     THTDTLPRAC GLKMMKWCSS VWPVSRRRIA SSAWLPRGWA TACATWSPRL RPSMFLQTCA
     SAPLCWSSPC RSGRCRRCLP TVDKTDFNHS EREPSFFLIN AAQSGGHKTL LYGHAILLRH
     SFSSMYLACL KTSRSQTDKL SFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRIGDDLIL
     VSLSSERYLH LSISNGNIQV DASFMQTLWN VHPICSGSNV EEGYLLGGHV IRLFHGHDEV
     VAIPGSDQSE EEQRIVNYET GKAGAKARSL WRLEPLRISW SGSHIRWGQP FRLRHLTTGH
     YLALTDDRGL VLQDRERSDT DATAFCFRAS KKQEKLEQSP KRDIEGMGVA EIKYGDSLCF
     IMHVATGLWL SYQAPDVKSA RLGPLKRRAC LHTEGHMDDG LTLQRCQHEE SRAARIIRNT
     TLLFNRFVRD LDCLGVKNRL VVFLPVEEVL QTLNDLIAYF QLPDVELEHE ERQIKLRSLK
     NRQNLFKQEG MLNLVSNCID RLNVYNSAAH FGECAGQEAG AAWKDILNLL YELLAALIRG
     NRNNCTQFSN NLDWLVSKLE RLESSSGILE VLHCILIESP EALNIIQRGH IKSIISLLYK
     HGRNHKILDV LCSLCVCNGV AVRTNQNLIC DHLLPKRDLL LQSQLVNVVQ SMRPNIFLGV
     SEGSAQYKKW YYELMIDQVD HFVTSEPTHL RVGWANTKGY APYPGGGEGW GGNGVGDDLY
     SFGFDGLHLW SGRVPRAAAS LNQHILTSED VVSCCLDLGA PSISFRINGQ PVQGMFENFN
     ADGLFFPVAS FSAGVKVRFL LGGRHGDFKF LPPSGYAPCY EALLPKEKMK VEPVKEYKRD
     VAGVRDLLGT AQLLSQASFI PTPVETSQII MPPHLEKVRD KLAENIHELW GMNKIELGWT
     YGKIRDDNKR QHPCLVDFSK LPETEKNYNL QMSTETLKTL LALGCRVVQV NPNAENSLKK
     IKLTKNYMMS NGYKPSPLDL SDIKLTPGQE LLVDKLAENA HNVWAKDRIK QGWTYGIQQD
     LKSKRNPRLV PYVLLDERTK KSNRDSLREA IRTLIGYGYN IEPSDQEGES GQTVERISVD
     KVRFFRVERT YAVKTGKWYF EFEAVTGGDM RVGWARPACK PDVELGTDAH AFVFDGYSPK
     GHCLHTGGRL FGRCWHAGDV VGCMINMQDK SMIFTLNGEI LITTKGSELC FTDFDTEDGF
     IPVCSLGLAQ VGRMNLGKDA STFKYYTMCG LQEGFEPFAV NMNREVTMWF SKRLPTFVNV
     PKDHNHIAVT RIDGTIDSPP CLKVSHKTFG SQNSNADMVL CRLSMPIEFH SVFKSSPIAD
     VNGIHEEDVL KVKHRYSSSH FTHGRLSAAR PEINNTVPCR YPLRSVRHSD ESRRVDYSNI
     TTVTIQIKFV WSKTCYYHSV RVFAGQDPAG VWVGWVTPDY HYYSNNFNLG KNRTVTVTLG
     DERGRVHERD SVKRSNCYMV WGGDATSAAH ASSRSNVDLE IGCLIDLATG LVTFTINGKE
     ISTSYQVEPN TKLFPAVFVR PTSANLFQFE LGKIKNAMPL SSATFKSEHK NPVPQCPPRL
     DVQTISAVLW SRMPNNFLKV DTARVSERHG WVVQCVEPLQ MLAVHIPEEN RCVDIMELSE
     QEDLRKFHYH TLKLYCALCA LGNTRVAHAL CSHLDQSQLL YTIDNQYLSG MLREGCYNVL
     ISIHLETAKE ARLMMKDEFI IPVTPETRSI RLFFDATKKH RPPGVGLSTS LKPRFNFAPP
     CFISTKQEQH LYSPQVPLDT LKEKAISMLT EAVQGGGHHI RDPVGGCVEY QFVPILKLIS
     TLLTMGVLAS EDVHQILLLI DPNVFRETRE EGNSGATDKE GLAGAVDKAV EAGEEEAAKE
     AKQPLKGLLE KRLPEPVKRQ MCELLHYFCD CELKHRIEAI VSFSDNFVSK LQFNQKYRYN
     ELMLALNMSA AVTAKKTKEF RSPPQEQINM LLTFSTGDDC PCPSDIQEEL YDFHNQLQLH
     CGIPMEEDQD EHYTSIRGRL LMLVNKIKGQ AHKSEEPSEK EQAAPSNLKE LISQTMVSWA
     QECHIQDPQL VRKMFSLLRR QYDSIGELLR AMRKTYTISA SSVQDTINLL ASLGQIRSLL
     SVRMGKEEEK LMIDGLGDIM NNKVFYQHPN LMRILGMHET VMEVMVNVLG GDKSQEIAFP
     KMVASCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA SPSMRGSTPL DVAASSVMDN
     NGLALALEEP DLEKVVTYLA GCGLQSCPML LAKGYPDIGW NPIEGERYLS FLRFAVFVNG
     ESVEENSSVV VKLLIRRPEC FGPALRGEGG NGLLAAMKEA IKISETPALD LPGSVHGVCS
     DVSADGDDEE EVVHMGNAIM SFYSALIDLL GRCAPEMHLI NKGKGEALRI RAILRSLVPT
     EDLVGIISIP LKMPIINKDG SVTEPDMSAS FCPDHKAPMV LFLDRVYGIE DQSFLLHLLE
     VGFLPDLRAA TSLDTEGLCT TETALAMNRY IGSALLPLLT RCAPLFAGTE HYASLIDSTL
     HTIYRLSKGR SLTKAQRDAI EECLLAVCKH LRPSMLQQLL RRLVFDVPLL SEYCKMPLRL
     LTNHYEQNWK YYCLPSGWGS YGTASEDELL LTKKLFWGIF DSLSQRKYDP ELFKMAMPCL
     SAIAGALPPD YVDASISTAV EKPVSVDAQG NFDPKPINTA NVSLPEKLEH FANKYGEHLH
     EKWSAEKVLL GWKYGDSVDE KAKIHPQLRT YKSLTEKEKE IYRWPIRETL KSMLAMGWSI
     DRTKDGESMS QQRESEKMRK ISQVSQVNSQ ANGFNPSPTD TSNVVLSREL QGMVEVVAEN
     YHNIWAKKKK SDLGSRVKGG GPHPLLVPYD TLTAREKARD REKAQDLFRF LQINGYSITR
     GLKDLEQDSS SMEKRFAYKF LKKLLKYVDQ AQEFIAHLEA MAASGKTDRS PHEQEIKFFA
     KVLLPLIDQY FKNHCLYFLS SPNKNLSSSG YASNKEKEMV TSLFCKLAAL VRHRISLFGS
     DSTTIVSCLH ILAHTLDTRT VMKSGSELVR LGLRTFFENA AEDLEKTFEN LKLGKFTHSR
     SQMKGVSQNI NYTTVALLPI LTALFEHITQ HHFGVDLLLE DVQVSCYRIL TSLYALGTGK
     NIYVERQLPA LGQCLATLAG AMPVAFLEPL LNTYNPCSVF NTKSARERAI LGIPGSVEEM
     CPGMPRLDGL MKDINDMAES GARYTEMPHV IEVVLPMLCN YLSYWWEKGP ENPLSSGGSV
     CCTTVTSEHL SVILGNILKI LNNNLGIDEA SWMKRIAVYV QPIISKARAD LLRSHFLPTL
     EKLKKKTVKV VSEEELLKAD GRGDTQEAEL LILDEFAVLC RDLYAFYPML IRYVDNNRSR
     WLKEPDADSN ELFRMVAEIF ILWCKSHNFK REEQNFVVQN EINNLSFLTG DNKTKMSKSG
     GQDQERRHKK RRGEFYSIQT SLIVAALKKM LPIGLNMCTP GDQELISLAK TRYLLKDTDE
     EVKDHIQQNL HLREKSEDPA VRWQLNLYRD RALRFEGPPD PEKVLDRIQR ISAAVFNLEQ
     VGRRLFFQVE QPLRSKKCVW QKLLSKQRKR AVVACFRMAP LYNLPRHRSI NLFLQAYQRI
     WIETEEYSFE EKLVQDLAKT QPKMEEEEEE EVKKQPDPLH QLILHFSHNA LTECSSLEED
     PLYIAYADMM AKSCAEGEEE EEGKEKTFEE KEMEKQKMLY QQARLHDRGA AEMVLQMISA
     SKGRLGAMVT VTLKLGISIL NGGNILVQQK MLDYLKEKRD VGFFKSLSGL MMSCSVLDLN
     AFERQNKAEG LGMVTEEGSS SKVLQDDEFT KDLFRFLQLL CEGHNNDFQN FLRTQTGNTT
     TVNIIISTVD YLLRLQESIS DFYWYYSGKD VIDEAGQRNF SRALAVAKQV FNSLTEYIQG
     PCVGNQQSLA HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLQQ DMVVMMLSLL
     EGNVVNGTIG KQMVDTLVES SSNVEMILKF FDMFLKLKDL TTSDSFKEYD PENKGVISKK
     DFQKSMENQK QYSQSEIEFL LSCAEADEND MFNYKQFVDR FHEPAKDIGF NVAVLLTNLS
     EHMPHDARLS TFLDLAESVL SYFEPYLGRI EIMGGAKRIE RVYFEISESS RTQWEKPQVK
     ESKRQFIFDV VNERGESEKM ELFVNFCEDT IFEMQLASQI SEPDPVERSR GRRGRQPERA
     GKPGRGRGGE RAAGVVLAFT VACISMRKSL CHFRQLLTLR SIRRQYRTFR KMTVREMVQG
     FFSFFWIIIT GFLHFFYSLV WGFFHILWTT MFGGGFVEGA KNMKVTDILG NMPDPTQFGI
     HGDVLELEKI EANEASALAE IGQMSQGDAA EADLMAELLN IHPRNQGKHG SEPGLGDVSE
     MVVGDAPSIA SAVKQKKAEM AAKKTASNGE HKSDSEKADL EDGEKNDHAK TKDNAPQGSS
     VGEKKAPKKR PGQKKEPPEA FMASFLASVE IYQTKILNYL ARNFYNLRFL ALFVAFAINF
     ILLFYKVTGD YSDDEDPWNG RRRSGEEEEE GALEYFILQE STGYMAPALR CLAILHTIIS
     FLCVVGYYYL KVPLVVFKRE KEIARKLEFA GLYITEQPSD DDIKGQWDRL VINTPSFPNN
     YWDKFVKRKV IKKYGDLYGA ERIAELLGLD KSALDFNPTE ETVTKEASLV SWLSSIDTKY
     HVWKMGVVFT DNSFLYLVWY TTMSILGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK
     QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG
     GIGDEIEDPA GDPYELYRIL FDITFFFFVI VILLAIIQVA GLIIDAFGEL RDQQEQVKED
     METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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