ID H2UIB2_TAKRU Unreviewed; 1567 AA.
AC H2UIB2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Kinase D interacting substrate 220 {ECO:0000313|Ensembl:ENSTRUP00000036683.3};
GN Name=KIDINS220 {ECO:0000313|Ensembl:ENSTRUP00000036683.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036683.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000036683.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000036683.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTRUT00000036814.3; ENSTRUP00000036683.3; ENSTRUG00000014349.3.
DR eggNOG; KOG0502; Eukaryota.
DR GeneTree; ENSGT00940000156714; -.
DR TreeFam; TF344032; -.
DR Proteomes; UP000005226; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF1; KINASE D-INTERACTING SUBSTRATE OF 220 KDA ISOFORM X1; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 10.
DR PROSITE; PS50088; ANK_REPEAT; 11.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 37..69
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 70..102
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 202..234
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 235..267
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 268..300
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 301..333
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 334..366
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 367..390
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 440..949
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1202..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1567 AA; 173449 MW; 401DE0022AA8B65A CRC64;
MTSLAIQSLF SFVEEDNLAA VKAHLDKFRD VDSRSDNGQT PLMVAAEQGN LEITQELIKR
GANVNLDDVD CWTALISAAK EGHLEVVREL LENNANPEHR DMGGWTALMW AAYKGRTDVA
DLLLEKGANP NITGQYSVYP IIWAAGRGHA EIVHLLLQHG AKVNCSDKYG TTPLIWASRK
GHYESVMHLL ANGADVDQEG ANSMTALIVA VKGGYTDVVK ELLKRNPNVN MTDKDGNTAL
AIAAKEGHVE IVQDLLDAGS YVNIPDRSGE TMLIGAVRGG HVEIVRALLN KYADIDIRGQ
DGKTALYWAV EKGNVTMVRD ILQCNPDTES CTKEGETPLI KATKMRNIEV VELLLDKGAK
VSAMDKKGDT PLHIAIRGRS RKLAELLLRN PKDGRLLYRP NKAGETPYNI DCTHQKSILT
QIFGAKHLSP SESDGDMLGY DLYSSALADI LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE
DEMKTFAGQQ IEPLFQFSWL VVFLTLLVCG SVSLVLGFTV DHKLAIAVSL SLLGLLYIFF
VLVYFGSRRE RESWNWAWII STLLARQIGY LELLLKLMFV NPPELPEQTT RALPVRFLFT
DYNRLSSVGG ETSMAEMIAT LSDACEREFG FMAARLFRVF KNDEVQGKAK WKKTCCVPSF
ILFSLTLGCL ITGLALLAIF KVDPENLTVN AVLIAMASVV GLALLLNCRT WWQVADSVFN
SQRKRLHNAA NNLHRLKSEG FMKVLKHEVE LISKMAKTID GFTQNQTRMA IIIDGLDACE
QDKVLQMLDT VRVLFSKGPF ISIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL
PVFLNSRGLS TAKKLCMVTP TNGEPLPSEG WHEDMERKMS LTSLDQSKFG SKNALNRRDT
YRRRQMQRTI TRQMSFDLTK LLVSEDWFSD ISPQTMRRLL NIVSITGRLL RANHIIFNWD
RLASWIHMTE EWPYRTSWII LFLEETDGVS DQVTLKTLYE RISKNIPMTK DVEPLLEIDG
DIRSFEIFLS SRMPVLTARD VEMFLPCTVN LDPKLREIIA DVRAAREQIN MGGVTYPTLP
LQDAGPRPQS MYSQGSVACS PTVAFARPLP PQPHSSYFSG MTGPQHPFYN RANVNGRVLS
QCNLDDLKKE MEMNFGDWQL FRNMVRLFRG VTHQTEPKRR SAVVQQDAAA FSLNLSFEEL
SGAGLEEPPR PSSNSQTSSM SSLNSQESSN DICRLTDKQQ AEYRDAYREY ISQMSQLEMA
GGGAERPHPG HQSSSDDIRH RSLVHRSAKE GADQDSRKSF TKRGSKAGDV TDFPSGADSQ
LLDTISEEDE NHSASCRTPG TKKKGAGSLY QKLPNDEDSG PEEADTTTPL LHKEASRSSS
QHAGPLTRPG FLTEISLDKK DSSDSGMRSS NSSSDRSLEE AGGDAEKGAM KRSLMELELE
GVVKKRGLLP SSLSGLQDAT VARMSICSEA PSEVSLVASS PEEGWTPSGL GNLNSGNDNT
AFNDNATNDN ADIGNRRPEP TTPCSTSVSP VIVITPGSTA ANTTTVASIH NQNLRSFSLG
DESESVL
//
