ID H2UJF6_TAKRU Unreviewed; 278 AA.
AC H2UJF6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=pancreatic elastase II {ECO:0000256|ARBA:ARBA00038991};
DE EC=3.4.21.71 {ECO:0000256|ARBA:ARBA00038991};
GN Name=CTRC {ECO:0000313|Ensembl:ENSTRUP00000037077.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000037077.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000037077.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000037077.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa.
CC Hydrolyzes elastin.; EC=3.4.21.71;
CC Evidence={ECO:0000256|ARBA:ARBA00036026};
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DR AlphaFoldDB; H2UJF6; -.
DR STRING; 31033.ENSTRUP00000037076; -.
DR MEROPS; S01.155; -.
DR Ensembl; ENSTRUT00000037209.3; ENSTRUP00000037077.3; ENSTRUG00000014497.3.
DR GeneTree; ENSGT00940000153216; -.
DR OrthoDB; 2495122at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24257; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER; 1.
DR PANTHER; PTHR24257:SF19; CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 2B; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..278
FT /note="pancreatic elastase II"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025562320"
FT DOMAIN 40..276
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 278 AA; 29710 MW; CCCFF7C2FB6F53AC CRC64;
MSLKMCSHHM AVRSMLVLYF LFASAHGCGI PSIPPVLSRV VAGEDARPHS WPWQVSLQSD
SSGRWSHVCG GTLISSEWVL TAAHCIDDEH GHRVLLGKHI LGASEEASQS RSTALIIAHE
DYNILLSRND IALIKLSSPV NASDTVTAAC LPDQGLILPH GAPCYVTGWG RLSTDGPQAD
VLQQVLLPVV DHDTCSQDDW WSVLATDKMV CAGGDGIAAG CNGDSGGPLN YQAADGSWEV
HGVVSFGSGQ GCNVPKKPTV FTQVSSYISW INWIMTTH
//
