ID H2UMZ5_TAKRU Unreviewed; 784 AA.
AC H2UMZ5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ligand of numb-protein X 1 {ECO:0000313|Ensembl:ENSTRUP00000038316.3};
GN Name=lnx1 {ECO:0000313|Ensembl:ENSTRUP00000038316.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038316.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000038316.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000038316.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2UMZ5; -.
DR STRING; 31033.ENSTRUP00000038316; -.
DR Ensembl; ENSTRUT00000038453.3; ENSTRUP00000038316.3; ENSTRUG00000014995.3.
DR eggNOG; KOG2177; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000158757; -.
DR InParanoid; H2UMZ5; -.
DR OMA; NHNMAPA; -.
DR OrthoDB; 3028121at2759; -.
DR TreeFam; TF330709; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16779; mRING-HC-C3HC3D_LNX1; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF14; E3 UBIQUITIN-PROTEIN LIGASE LNX; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 66..104
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 307..392
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 431..514
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 557..643
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 694..780
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 183..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 86216 MW; 9CDE6474DBCD2DEA CRC64;
MSLQEENLQT HVAEAMAEAS TPPLSPVDFG SLPPSPNMCG LCGHSHQLEE NHEYEYKDEV
DDDLVCHICL QPLIRPLDTP CGHTYCQECL TNFLLESDFC PVCRAPLMLQ SCRKSSVLVH
KLLDKLPVAC PFTVHCSEVV PRGELQDHIR SRCKGASHYG LSADRKRRSQ EGECTDSTSE
LTIATLPNDS PNSATVALLS DDPGLVNPAF DPSMEDHNSQ SGSTTSLAAR SSSKKSEFRN
FDRSSVRSRS FKRLNRAFSV LRRTKSGNAV SNETSEERDN TRNSSVPPEV LALPQLHHLI
PDGELTSIKI TRVESSEPLA ISVVGGNETP LVRILIQDIY REGVIARDGR LLPGDMILKV
NGIDISNVPH CFAVATLKQP CQLLRLTVLR EQRHRYRSHS HSHSYGHGQD VAGGHPSHGV
HHHPLRDDSI HVVLNKSTPD EQLGIKLVRR QEEHGVYISH LLEGGMAARD GQLCVGDRVL
AINGHDLRYG APEHAALLIQ ASEECVHFIV SRQICLPSPD ILQEAPWGMD GPPPYSPVDL
EQTLLDSCQK PACYEKTVTL SKEPYDSLGM TVAGGMSSRG WDLPVYVTNV DPDGVVGKEG
SIRKGDILLN VNGMELTGVT RSEAVANLKN TSSPVVLKVL EMCRPEEGLQ ECTLPPCLTA
SPTDSTKSPL PNDDYSPLWV SWLQLPRHLY CCKDIVLRRS TSGSLGFSIV GGREEVNCNQ
SFFIRSIVEG TPAYNDGRIR CGDILLEVNG KSTWGMTHTA LVRFLKELRG RITLTIVSWP
GSLL
//
