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Database: UniProt
Entry: H2UPW0_TAKRU
LinkDB: H2UPW0_TAKRU
Original site: H2UPW0_TAKRU 
ID   H2UPW0_TAKRU            Unreviewed;      5028 AA.
AC   H2UPW0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000038981};
GN   Name=LOC101073831 {ECO:0000313|Ensembl:ENSTRUP00000038981};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038981, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000038981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000038981}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000038981}.
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DR   Ensembl; ENSTRUT00000039121; ENSTRUP00000038981; ENSTRUG00000015260.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4316   4336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4555   4573       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4632   4654       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4771   4792       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4830   4850       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4909   4932       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    269       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      275    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      589    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1018   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1347   1558       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     3645   3672       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5028 AA;  570206 MW;  4008A5CC17E9D3EE CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSGMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL AEGTSFLTGG HVLRLFHGHM DECLAIATPE
     EGEEKRRMAH YEGGSVCSQA RSLWRLEPLR ISWSGSHMKW GQSFRIRHIT TGRYLCLDEE
     KGLLVVDPER ANTKLSAFCF RASKEKVDVA QKRDVEGMGI PEIKYGESMC FVQHVSTGLW
     LTYASLDAKA ARLGMMKRKV ILHQEGHMDD ALTVSRSQTE ESQAARMIYS TVGLFRQFIK
     GLDTLTGKNK SPGALSLPLE GVILSLQDLI FYFRPPDEEL EHEEKQTKLR SLRNRQNLFQ
     EEGMITIVLE CIDRLNVYNT AAHFSEFAGE EAAESWKEIV NLLYELLASL IRGNRSNCAL
     FCDNLDWLVS KLDRLEASSG ILEVLYCVLI ESPEVLNIIQ ENHIKSIISL LDKHGRNHKV
     LDVLRSLCVC NGVAVRSNQN LITENLLPGR DLLLQTNIVN YVTSVRPNIF LGTCEGSTQY
     KKWYYEVMVD HVEAFVTAQA THLRVGWAMT EGYSPYPGGG EGWGGNGVGD DLYSYSFDGL
     HLWSGTVPRQ VASPNAHTLA ADDVVSCCLD LSVPSISFRI NGHPVQGMFE NFNVDSLFFP
     VISFSAGVKA RFLLGGRHGD FKFMPPPGYA PCYEALLPRE RMRIEPIKEY KHDFNGVRNL
     LGPTLSLTHT SFTPCPVDTV QIVLPPHLER IREKLAENIH ELWAVTRIEQ GWTYGSPSKF
     RDDNKKLHPC LVDFQSLPEP ERNYNLQMSA ETLKTLLALG CHVGMGDEKA EENLKKIKLP
     KTYVMSNAYK PAPLDLSHVK LTPNQNQLVE KLAENGHNVW ARDRVRQGWT YSIVQDILNK
     RNPRLVPYIL LDERTKKTNR DSVNNAVRTL IGYGYNIEPP DQESTGHGLE NTRGDKVRIF
     RAEKSYAVTQ GKWYFEFEAV TTGEMRVGWA RPNVHSDTEL GADELAYVFN GNKAQRWHIG
     NEPFGRQWQS GDVVGCMIDL TEMNIMFTLN GEMLISDSGS EMAFKDIEIG EGFIPVCTLG
     LSQVGRINLG QNVSSLRYFA ICGLQEGFEP FAINMKRDTT MWFSKSLPQF VPVPADHNHI
     EVSRVDGTVD SAPCLKLTHK TYGSQNANTD MLFLRLSMPI QFHATFKVPA GTTPLTRALT
     IPEDVAVVEP DSEFEVLKKS ASRKEQEEDK KEPSVPKEIL AENEKDTMSE KGKKRGFFSK
     AKKAAMTPLA PPPPPTVPRL VEDVVPDDRD DPEIILSTTT YYYSVRIFAG QEPSGVWVGW
     VTPDYHQYDQ TFDLSKVRSV TVTVGDDKGN IYNSMKHSNC YMVWGDDLVS NHQTRFSQED
     MVIGCLVDLA TGLMTFTANG KEINTFYQVE PNTKLFPAVF VQPLSQNMVQ LELGKLKNIM
     PISAAMFRSE RNNPVPQCPP RLDVQMLTPV IWSRMPNRFL NPDVGRVSER LGWVVECTEP
     LIMMALHIPE ENRCIDILEL SERQDLMKFH YHTLMLYCAV CALGNNRVAH ALCSHVDESQ
     LFYATENTYL PGPLRSGYYD LLISIHLESA KRARLGTNRE FIVPMTEETL SIKLYPDAVK
     AHSLPGVGLT TCLRPKLHFS SINFVGTDLD LYTLSPVFPL QELKNRAISM LTEAVLDGSQ
     AMRDPVGGSV EFHFVPILKL ISTLLIMGIF NDDDTKHILK MIDPNVFSGD DTEEEAEPKE
     EGEEEEKEEG EAKTGKVDGE KMEEEKEAEV VAVDLKDEEE GLEEGLLQMK LPESVKLQMC
     TLLQFFCDCE LRHRVEAIVA YSDKFVHNIQ DNQRIRYNQL MRAFTMSAAE TARKTREFRS
     PPQDQVLLLT NFKHSLEEEE CPVPDNVRET LKEFHNDLLL HCGHVGIHIE EEPVEEEVDT
     SLRGRLLSLV DKIKSIRGKK TEEKPEVEEE TKPSTLQELI SHTMIHWAQE SFIQNPELVR
     LMFSLLHRQY DGLGELIRAL PKAYAINAVS VQDTMDLLEC LGQIRSLLIV QMGPEEERLM
     IQSIGNIMNN KVFYQHPNLM RALGMHETVM EVMVNVLGGG GDSKEIRFPQ MVTNCCRFLC
     YFCRISRQNQ RSMFDHLSYL LQNSSIGLGM RGSTPLDVAA ASCIDNNELA LALQEQDLEM
     VVTYLAGCGL QMCPMLLSKC YPDIGWNPCG GERYLDFLRF AVFVNGESVE ENANVVVRLL
     IRRPECFGPA LRGEGGNGLL AAMEEAIKIS EDPARDGPTV KKDRRFMFGG EEQQEENRVH
     LGNAIMSFYS ALIDLLGRCA PEMHLIQAGK GEALRIRAIL RSLVPIEDLV GVISLPVQIP
     SYGKDSQIVE PKMSASFVPD HKASMVLFLD RVYGIDNQDF LLHVLEVGFL PDMRAAASLD
     TVAFSTTEMA LALNRYLCSA VLPLLTKCAP LFAGTDHRAI MIDSMLHTIY RLSRGRALTK
     AQRDVIEECL MSLCKYLRPS MLQHLLRRLV FDVPILNEYA KMPLKLLTNH YERCWKYYCL
     PNGWANFGVT SEEELHLSRK LFWGIFESLA HKKFDAELFK IAMPCLCAIA GAIPPDYVDA
     SYSSHTEKKA SVDAEGNFDP KPVETTNTII PERLDAFINK YAEHTHDKWA FEKIQNNWTY
     GEVLDEDAKT HPMLRPYKTF SEKDKEIYRW PIKESIKAML AWEWTLEKAR DGEGEVEKKA
     ATRKISQTAQ ATYDPSHGYS PQPIDISGMT LSRELQSMAE QLAENYHNTW GRKKKVELQS
     KGGGTHPLLV PYDTLTAKEK ARDREKAQDL LKFLQLNGYA VTRGMKDMEQ DISSIEKRFA
     YGFLQKLLKW MDIAQEFIAH LEAVVSSGRV EKSPHEQEIK FFAKILLPLV NQYFKNHCLY
     FLSTPAKVLG SGGHSSNKEK EMIASIFCKL AALVRHRVSL FGTDASAVVN CLHILSRSLD
     ARTVMKSGPE IVKAGLRQFF ESAADDIEKM VENLKLGKVS SRNQVKGVSQ NINYTTIALL
     PVLTSLFDHI AQHQFGDDVI LDDLQISCYR IMCSIYSLGT VKTPHAEKQR PALGECLAHL
     AAAMPVAFLE PTLNEFNTFS VYTTKTPRER SILGLPSQVE ELCPDIPELE VLMKDIHDLA
     ESGARYTEMP HVIEITLPML CNYLPRWWER GLENFPEQEG QICTSVTSEQ LNQLLGSIMK
     IVVNNLGIDE ASWMKRLAVF AQPIVSRAKP EMLKSHFIPT MEKLKKRCGK VVAEEDHLRM
     EGKTEVDSEN GTIRDEFAVL CRDLYALYPL LIRYVDNSRA RWLTNPDPDA EELFRMVGEV
     FIFWSKSHNF KREEQNFVVM NEINNMSFLT ADSKSKMSKA GDGESGGSEQ ERTKKKRRGD
     RYSVQTSLIV AALKKLLPIG LNMCSPADQE LINLAKIRYS LKDTDEEVRE FLHNNLHLQG
     KVEDPAMRWQ MSLYKEMAGK AEDAEDPEKV VKRVQEVSAV LYHIEVTEHP FKSKKMVWHK
     LLSKQRRRAV VACFRMTPLY NIITHRATNM FLDAYKRNWL ETEGYSFEDK MIDDLSKAME
     EEEEEEEETE RKPDPLHQLI LHFSRTALTE KMKLDVDHLY MSYADIMAKS CHIGEEDEGG
     EQEGEEPSFE EKEMEKQRLL YQQSRLHNRG AAEMVLQMIS ACKGEPGAMV SSTLKLGISI
     LNGGNSDVQQ KMLDYLKDKK DVGFFLSIQS LMQTCSVLDL NAFERQNKAE GLGMVSEEGT
     NKKLERDEKV MADDEFTCDL FRFLQLLCEG HNNDFQNYLR TQTGSTTTIN VIICTVDYLL
     RLQESISDFY WYYSGKDIID EPGKRNFSKA MNVAKQVFNS LTEYIQGPCT GNQQSLAHSR
     LWDAVVGFLH VFAHMMMKLA QMHPDPGQRT GDSSQIGLLK ELLDLQKDMV VMLLSLLEGN
     VVNGTIAKQM VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFRDYVTDP RGLISKKDFS
     KAMDSQKQYT PAEIQFLLSC SEADENEMIN FEEFADRFQE PAKDIGFNIA VLLTNLSEHV
     PHDTRLQNFL EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEANRNQ WEMPQVRESK
     RQFIFDVVNE GGESEKMEMF VNFCEDTIFE MNIAASISEP EGEAAEEEDD EEEEEGGGQE
     GEPAEGEEGN GEEHAPESTS AFADFLKSVV NFFNMFTFRN LRRRYRRFRK MTVKEMVIGL
     ATFVYTVVMG ILMFVYSICK GFFTLIWKVL FGGGLVESAK KMTVTDILAS MPDPTQDEVH
     GELPPEPGSR EDQDTEGGAD LLDPVGGEEE EEDSEEREGG RLPGFNTPGG LGDFGETTPE
     EPPTPEGTPL LKRKLVSRHN QTVGGQGEEE NAEHEEPPQE TEKAESSTEN GEKAKKPEAE
     PEVKEEEPVE EEEITVKAKA KKSKKPVEEG FELWNELEIQ RVKFMNYLSR NFYNLRYLAL
     FIAFALNFIL LFYKVSDSPP GEEDFEGSGS GLFEGSGVQE DGSGLDDGGE DDDEEGPLYY
     FLEESTGYME PAMAFLSIVH TIISFLCIIG YNCLKVPLVI FKREKELARK LEFDGVYVTE
     QPEDDDIKGQ WDRLVLNTPS FPNNYWDKFV KRKVLDKYGD IYGRERIAEL LGMDLASLDV
     SAMTHEKKPE PDTSMFSWIT SIDIKYQIWK FGVVFTDNTF LYLVWYFLMS ILGHYNNFFF
     AAHLLDIAMG VKTLRTILSS VTHNGKQLMM TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE
     DEPDMKCDDM MTCYLFHMYV GVRAGGGIGD EIEDPAGDEY ELYRVVFDIT FFFFVIVILL
     AIIQGLIIDA FGELRDQQEQ VREDMETKCF ICGIGSDYFD TTPHGFETHT LEEHNLANYM
     FFLMYLINKD ETEHTGQESY VWKMYQERCW DFFPAGDCFR KQYEDQLG
//
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