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Database: UniProt
Entry: H2UPW2_TAKRU
LinkDB: H2UPW2_TAKRU
Original site: H2UPW2_TAKRU 
ID   H2UPW2_TAKRU            Unreviewed;      5009 AA.
AC   H2UPW2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000038983};
GN   Name=LOC101073831 {ECO:0000313|Ensembl:ENSTRUP00000038983};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038983, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000038983}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000038983}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000038983}.
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DR   Ensembl; ENSTRUT00000039123; ENSTRUP00000038983; ENSTRUG00000015260.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4298   4318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4532   4550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4613   4635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4773       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4811   4831       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4890   4913       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1343   1554       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     3637   3664       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5009 AA;  568259 MW;  EA482D62BE91611D CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSGMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL GFLTGGHVLR LFHGHMDECL AIATPEEGEE
     KRRMAHYEGG SVCSQARSLW RLEPLRISWS GSHMKWGQSF RIRHITTGRY LCLDEEKGLL
     VVDPERANTK LSAFCFRASK EKVDVAQKRD VEGMGIPEIK YGESMCFVQH VSTGLWLTYA
     SLDAKAARLG MMKRKVILHQ EGHMDDALTV SRSQTEESQA ARMIYSTVGL FRQFIKGLDT
     LTGKNKSPGA LSLPLEGVIL SLQDLIFYFR PPDEELEHEE KQTKLRSLRN RQNLFQEEGM
     ITIVLECIDR LNVYNTAAHF SEFAGEEAAE SWKEIVNLLY ELLASLIRGN RSNCALFCDN
     LDWLVSKLDR LEASSGILEV LYCVLIESPE VLNIIQENHI KSIISLLDKH GRNHKVLDVL
     RSLCVCNGVA VRSNQNLITE NLLPGRDLLL QTNIVNYVTS VRPNIFLGTC EGSTQYKKWY
     YEVMVDHVEA FVTAQATHLR VGWAMTEGYS PYPGGGEGWG GNGVGDDLYS YSFDGLHLWS
     GTVPRQVASP NAHTLAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNV DSLFFPVISF
     SAGVKARFLL GGRHGDFKFM PPPGYAPCYE ALLPRERMRI EPIKEYKHDF NGVRNLLGPT
     LSLTHTSFTP CPVDTVQIVL PPHLERIREK LAENIHELWA VTRIEQGWTY GSPSKFRDDN
     KKLHPCLVDF QSLPEPERNY NLQMSAETLK TLLALGCHVG MGDEKAEENL KKIKLPKTYV
     MSNAYKPAPL DLSHVKLTPN QNQLVEKLAE NGHNVWARDR VRQGWTYSIV QDILNKRNPR
     LVPYILLDER TKKTNRDSVN NAVRTLIGYG YNIEPPDQES TGHGLENTRG DKVRIFRAEK
     SYAVTQGKWY FEFEAVTTGE MRVGWARPNV HSDTELGADE LAYVFNGNKA QRWHIGNEPF
     GRQWQSGDVV GCMIDLTEMN IMFTLNGEML ISDSGSEMAF KDIEIGEGFI PVCTLGLSQV
     GRINLGQNVS SLRYFAICGL QEGFEPFAIN MKRDTTMWFS KSLPQFVPVP ADHNHIEVSR
     VDGTVDSAPC LKLTHKTYGS QNANTDMLFL RLSMPIQFHA TFKVPAGTTP LTRALTIPED
     VAVVEPDSEF EVLKKSASRK EQEEDKKEPS VPKEILAENE KDTMSEKGKK RGFFSKAKKA
     AMTPLAPPPP PTVPRLVEDV VPDDRDDPEI ILSTTTYYYS VRIFAGQEPS GVWVGWVTPD
     YHQYDQTFDL SKVRSVTVTV GDDKGNIYNS MKHSNCYMVW GDDLVSNHQT RFSQEDMVIG
     CLVDLATGLM TFTANGKEIN TFYQVEPNTK LFPAVFVQPL SQNMVQLELG KLKNIMPISA
     AMFRSERNNP VPQCPPRLDV QMLTPVIWSR MPNRFLNPDV GRVSERLGWV VECTEPLIMM
     ALHIPEENRC IDILELSERQ DLMKFHYHTL MLYCAVCALG NNRVAHALCS HVDESQLFYA
     TENTYLPGPL RSGYYDLLIS IHLESAKRAR LGTNREFIVP MTEETLSIKL YPDAVKAHSL
     PGVGLTTCLR PKLHFSSINF VGTDLDLYTL SPVFPLQELK NRAISMLTEA VLDGSQAMRD
     PVGGSVEFHF VPILKLISTL LIMGIFNDDD TKHILKMIDP NVFSGKDDEE EEAEPKEEGE
     EEEKEEGEAK TGKVDGEKME EEKEAEVVAV DLKDEEEGLE EGLLQMKLPE SVKLQMCTLL
     QFFCDCELRH RVEAIVAYSD KFVHNIQDNQ RIRYNQLMRA FTMSAAETAR KTREFRSPPQ
     DQVLLLTNFK HSLEEEECPV PDNVRETLKE FHNDLLLHCG HVGIHIEEEP VEEEVDTSLR
     GRLLSLVDKI KSIRGKKTEE KPEVEEETKP STLQELISHT MIHWAQESFI QNPELVRLMF
     SLLHRQYDGL GELIRALPKA YAINAVSVQD TMDLLECLGQ IRSLLIVQMG PEEERLMIQS
     IGNIMNNKVF YQHPNLMRAL GMHETVMEVM VNVLGGGGDS KEIRFPQMVT NCCRFLCYFC
     RISRQNQRSM FDHLSYLLQN SSIGLGMRGS TPLDVAAASC IDNNELALAL QEQDLEMVVT
     YLAGCGLQMC PMLLSKCYPD IGWNPCGGER YLDFLRFAVF VNGESVEENA NVVVRLLIRR
     PECFGPALRG EGGNGLLAAM EEAIKISEDP ARDGPTVKKD RRFMFGGEEQ QEENRVHLGN
     AIMSFYSALI DLLGRCAPEM HLIQAGKGEA LRIRAILRSL VPIEDLVGVI SLPVQIPSYG
     KDSQIVEPKM SASFVPDHKA SMVLFLDRVY GIDNQDFLLH VLEVGFLPDM RAAASLDTVA
     FSTTEMALAL NRYLCSAVLP LLTKCAPLFA GTDHRAIMID SMLHTIYRLS RGRALTKAQR
     DVIEECLMSL CKYLRPSMLQ HLLRRLVFDV PILNEYAKMP LKLLTNHYER CWKYYCLPNG
     WANFGVTSEE ELHLSRKLFW GIFESLAHKK FDAELFKIAM PCLCAIAGAI PPDYVDASYS
     SHTEKKASVD AEGNFDPKPV ETTNTIIPER LDAFINKYAE HTHDKWAFEK IQNNWTYGEV
     LDEDAKTHPM LRPYKTFSEK DKEIYRWPIK ESIKAMLAWE WTLEKARDGE GEVEKKAATR
     KISQTAQATY DPSHGYSPQP IDISGMTLSR ELQSMAEQLA ENYHNTWGRK KKVELQSKGG
     GTHPLLVPYD TLTAKEKARD REKAQDLLKF LQLNGYAVTR GMKDMEQDIS SIEKRFAYGF
     LQKLLKWMDI AQEFIAHLEA VVSSGRVEKS PHEQEIKFFA KILLPLVNQY FKNHCLYFLS
     TPAKVLGSGG HSSNKEKEMI ASIFCKLAAL VRHRVSLFGT DASAVVNCLH ILSRSLDART
     VMKSGPEIVK AGLRQFFESA ADDIEKMVEN LKLGKVSSRN QVKGVSQNIN YTTIALLPVL
     TSLFDHIAQH QFGDDVILDD LQISCYRIMC SIYSLGTVKT PHAEKQRPAL GECLAHLAAA
     MPVAFLEPTL NEFNTFSVYT TKTPRERSIL GLPSQVEELC PDIPELEVLM KDIHDLAESG
     ARYTEMPHVI EITLPMLCNY LPRWWERGLE NFPEQEGQIC TSVTSEQLNQ LLGSIMKIVV
     NNLGIDEASW MKRLAVFAQP IVSRAKPEML KSHFIPTMEK LKKRCGKVVA EEDHLRMEGK
     TEVDSENGTI RDEFAVLCRD LYALYPLLIR YVDNSRARWL TNPDPDAEEL FRMVGEVFIF
     WSKSHNFKRE EQNFVVMNEI NNMSFLTADS KSKMSKSGGS EQERTKKKRR GDRYSVQTSL
     IVAALKKLLP IGLNMCSPAD QELINLAKIR YSLKDTDEEV REFLHNNLHL QGKVEDPAMR
     WQMSLYKEMA GKAEDAEDPE KVVKRVQEVS AVLYHIEVTE HPFKSKKMVW HKLLSKQRRR
     AVVACFRMTP LYNIITHRAT NMFLDAYKRN WLETEGYSFE DKMIDDLSKA MEEEEEEEEE
     TERKPDPLHQ LILHFSRTAL TEKMKLDVDH LYMSYADIMA KSCHIGEEDE GGEQEGEEPS
     FEEKEMEKQR LLYQQSRLHN RGAAEMVLQM ISACKGEPGA MVSSTLKLGI SILNGGNSDV
     QQKMLDYLKD KKDVGFFLSI QSLMQTCSVL DLNAFERQNK AEGLGMVSEE GTNKKLERDE
     KVMADDEFTC DLFRFLQLLC EGHNNDFQNY LRTQTGSTTT INVIICTVDY LLRLQESISD
     FYWYYSGKDI IDEPGKRNFS KAMNVAKQVF NSLTEYIQGP CTGNQQSLAH SRLWDAVVGF
     LHVFAHMMMK LAQDSSQIGL LKELLDLQKD MVVMLLSLLE GNVVNGTIAK QMVDMLVESS
     SNVEMILKFF DMFLKLKDIV ASDAFRDYVT DPRGLISKKD FSKAMDSQKQ YTPAEIQFLL
     SCSEADENEM INFEEFADRF QEPAKDIGFN IAVLLTNLSE HVPHDTRLQN FLEQAESVLN
     YFRPFLGRIE IMGASRKIER IYFEISEANR NQWEMPQVRE SKRQFIFDVV NEGGESEKME
     MFVNFCEDTI FEMNIAASIS EPEGEAAEEE DDEEEEEGGG QEGEPAEGEE GNGEEHAPES
     TSAFADFLKS VVNFFNMFTF RNLRRRYRRF RKMTVKEMVI GLATFVYTVV MGILMFVYSI
     CKGFFTLIWK VLFGGGLVES AKKMTVTDIL ASMPDPTQDE VHGELPPEPG SREDQDTEGG
     ADLLDPVGGE EEEEDSEERE GGRLPGFNTP GGLGDFGETT PEEPPTPEGT PLLKRKLLAA
     TVGGQGEEEN AEHEEPPQET EKADTENGEK AKKPEAEPEV KEEEPVEEEE ITVKAKAKKS
     KKPVEEGFEL WNELEIQRVK FMNYLSRNFY NLRYLALFIA FALNFILLFY KVSDSPPGEE
     DFEGSGLFEG SGLFEGSGVQ EDGSGLDDGG EDDDEEGPLY YFLEESTGYM EPAMAFLSIV
     HTIISFLCII GYNCLKVPLV IFKREKELAR KLEFDGVYVT EQPEDDDIKG QWDRLVLNTP
     SFPNNYWDKF VKRKVLDKYG DIYGRERIAE LLGMDLASLD VSAMTHEKKP EPDTSMFSWI
     TSIDIKYQIW KFGVVFTDNT FLYLVWYFLM SILGHYNNFF FAAHLLDIAM GVKTLRTILS
     SVTHNGKQLM MTVGLLAVVV YLYTVVAFNF FRKFYNKSED EDEPDMKCDD MMTCYLFHMY
     VGVRAGGGIG DEIEDPAGDE YELYRVVFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE
     QVREDMETKC FICGIGSDYF DTTPHGFETH TLEEHNLANY MFFLMYLINK DETEHTGQES
     YVWKMYQERC WDFFPAGDCF RKQYEDQLG
//
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