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Database: UniProt
Entry: H2UPW4_TAKRU
LinkDB: H2UPW4_TAKRU
Original site: H2UPW4_TAKRU 
ID   H2UPW4_TAKRU            Unreviewed;      5004 AA.
AC   H2UPW4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 35.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000038985};
GN   Name=LOC101073831 {ECO:0000313|Ensembl:ENSTRUP00000038985};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000038985, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000038985}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000038985}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000038985}.
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DR   Ensembl; ENSTRUT00000039125; ENSTRUP00000038985; ENSTRUG00000015260.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4302   4322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4527   4545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4608   4630       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4747   4768       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4806   4826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4885   4908       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      585    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1343   1554       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     3641   3668       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5004 AA;  567463 MW;  64AE953AE7A0F1CE CRC64;
     MAEGGEGEEE IQFLRTDDQV VLQCTASVLK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICTFILE QSLSVRALQE MLANTVEMTE SSQGGGHRTL LYGHAILLRH NHSGMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPISSGCEL GFLTGGHVLR LFHGHMDECL AIATPEEGEE
     KRRMAHYEGG SVCSQARSLW RLEPLRISWS GSHMKWGQSF RIRHITTGRY LCLDEEKGLL
     VVDPERANTK LSAFCFRASK EKVDVAQKRD VEGMGIPEIK YGESMCFVQH VSTGLWLTYA
     SLDAKAARLG MMKRKVILHQ EGHMDDALTV SRSQTEESQA ARMIYSTVGL FRQFIKGLDT
     LTGKNKSPGA LSLPLEGVIL SLQDLIFYFR PPDEELEHEE KQTKLRSLRN RQNLFQEEGM
     ITIVLECIDR LNVYNTAAHF SEFAGEEAAE SWKEIVNLLY ELLASLIRGN RSNCALFCDN
     LDWLVSKLDR LEASSGILEV LYCVLIESPE VLNIIQENHI KSIISLLDKH GRNHKVLDVL
     RSLCVCNGVA VRSNQNLITE NLLPGRDLLL QTNIVNYVTS VRPNIFLGTC EGSTQYKKWY
     YEVMVDHVEA FVTAQATHLR VGWAMTEGYS PYPGGGEGWG GNGVGDDLYS YSFDGLHLWS
     GTVPRQVASP NAHTLAADDV VSCCLDLSVP SISFRINGHP VQGMFENFNV DSLFFPVISF
     SAGVKARFLL GGRHGDFKFM PPPGYAPCYE ALLPRERMRI EPIKEYKHDF NGVRNLLGPT
     LSLTHTSFTP CPVDTVQIVL PPHLERIREK LAENIHELWA VTRIEQGWTY GSPSKFRDDN
     KKLHPCLVDF QSLPEPERNY NLQMSAETLK TLLALGCHVG MGDEKAEENL KKIKLPKTYV
     MSNAYKPAPL DLSHVKLTPN QNQLVEKLAE NGHNVWARDR VRQGWTYSIV QDILNKRNPR
     LVPYILLDER TKKTNRDSVN NAVRTLIGYG YNIEPPDQES TGHGLENTRG DKVRIFRAEK
     SYAVTQGKWY FEFEAVTTGE MRVGWARPNV HSDTELGADE LAYVFNGNKA QRWHIGNEPF
     GRQWQSGDVV GCMIDLTEMN IMFTLNGEML ISDSGSEMAF KDIEIGEGFI PVCTLGLSQV
     GRINLGQNVS SLRYFAICGL QEGFEPFAIN MKRDTTMWFS KSLPQFVPVP ADHNHIEVSR
     VDGTVDSAPC LKLTHKTYGS QNANTDMLFL RLSMPIQFHA TFKVPAGTTP LTRALTIPED
     VAVVEPDSEF EVLKKSASRK EQEEDKKEPS VPKEILAENE KDTMSEKGKK RGFFSKAKKA
     AMTPLAPPPP PTVPRLVEDV VPDDRDDPEI ILSTTTYYYS VRIFAGQEPS GVWVGWVTPD
     YHQYDQTFDL SKVRSVTVTV GDDKGNIYNS MKHSNCYMVW GDDLVSNHQT RFSQEDMVIG
     CLVDLATGLM TFTANGKEIN TFYQVEPNTK LFPAVFVQPL SQNMVQLELG KLKNIMPISA
     AMFRSERNNP VPQCPPRLDV QMLTPVIWSR MPNRFLNPDV GRVSERLGWV VECTEPLIMM
     ALHIPEENRC IDILELSERQ DLMKFHYHTL MLYCAVCALG NNRVAHALCS HVDESQLFYA
     TENTYLPGPL RSGYYDLLIS IHLESAKRAR LGTNREFIVP MTEETLSIKL YPDAVKAHSL
     PGVGLTTCLR PKLHFSSINF VGTDLDLYTL SPVFPLQELK NRAISMLTEA VLDGSQAMRD
     PVGGSVEFHF VPILKLISTL LIMGIFNDDD TKHILKMIDP NVFSGDDTEE EAEPKEEGEE
     EEKEEGEAKT GKVDGEKMEE EKEAEVVAVD LKDEEEGLEE GLLQMKLPES VKLQMCTLLQ
     FFCDCELRHR VEAIVAYSDK FVHNIQDNQR IRYNQLMRAF TMSAAETARK TREFRSPPQD
     QVLLLTNFKH SLEEEECPVP DNVRETLKEF HNDLLLHCGH VGIHIEEEPV EEEVDTSLRG
     RLLSLVDKIK SIRGKKTEEK PEVEEETKPS TLQELISHTM IHWAQESFIQ NPELVRLMFS
     LLHRQYDGLG ELIRALPKAY AINAVSVQDT MDLLECLGQI RSLLIVQMGP EEERLMIQSI
     GNIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGGDSK EIRFPQMVTN CCRFLCYFCR
     ISRQNQRSMF DHLSYLLQNS SIGLGMRGST PLDVAAASCI DNNELALALQ EQDLEMVVTY
     LAGCGLQMCP MLLSKCYPDI GWNPCGGERY LDFLRFAVFV NGESVEENAN VVVRLLIRRP
     ECFGPALRGE GGNGLLAAME EAIKISEDPA RDGPTVKKDR RFMFGGEEQQ EENRVHLGNA
     IMSFYSALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV PIEDLVGVIS LPVQIPSYGK
     DSQIVEPKMS ASFVPDHKAS MVLFLDRVYG IDNQDFLLHV LEVGFLPDMR AAASLDTVAF
     STTEMALALN RYLCSAVLPL LTKCAPLFAG TDHRAIMIDS MLHTIYRLSR GRALTKAQRD
     VIEECLMSLC KYLRPSMLQH LLRRLVFDVP ILNEYAKMPL KLLTNHYERC WKYYCLPNGW
     ANFGVTSEEE LHLSRKLFWG IFESLAHKKF DAELFKIAMP CLCAIAGAIP PDYVDASYSS
     HTEKKASVDA EGNFDPKPVE TTNTIIPERL DAFINKYAEH THDKWAFEKI QNNWTYGEVL
     DEDAKTHPML RPYKTFSEKD KEIYRWPIKE SIKAMLAWEW TLEKARDGEG EVEKKAATRK
     ISQTAQATYD PSHGYSPQPI DISGMTLSRE LQSMAEQLAE NYHNTWGRKK KVELQSKGGG
     THPLLVPYDT LTAKEKARDR EKAQDLLKFL QLNGYAVTRG MKDMEQDISS IEKRFAYGFL
     QKLLKWMDIA QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILLPLVNQYF KNHCLYFLST
     PAKVLGSGGH SSNKEKEMIA SIFCKLAALV RHRVSLFGTD ASAVVNCLHI LSRSLDARTV
     MKSGPEIVKA GLRQFFESAA DDIEKMVENL KLGKVSSRNQ VKGVSQNINY TTIALLPVLT
     SLFDHIAQHQ FGDDVILDDL QISCYRIMCS IYSLGTVKTP HAEKQRPALG ECLAHLAAAM
     PVAFLEPTLN EFNTFSVYTT KTPRERSILG LPSQVEELCP DIPELEVLMK DIHDLAESGA
     RYTEMPHVIE ITLPMLCNYL PRWWERGLEN FPEQEGQICT SVTSEQLNQL LGSIMKIVVN
     NLGIDEASWM KRLAVFAQPI VSRAKPEMLK SHFIPTMEKL KKRCGKVVAE EDHLRMEGKT
     EVDSENGTIR DEFAVLCRDL YALYPLLIRY VDNSRARWLT NPDPDAEELF RMVGEVFIFW
     SKSHNFKREE QNFVVMNEIN NMSFLTADSK SKMSKAGDGE SGGSEQERTK KKRRGDRYSV
     QTSLIVAALK KLLPIGLNMC SPADQELINL AKIRYSLKDT DEEVREFLHN NLHLQGKVED
     PAMRWQMSLY KEMAGKAEDA EDPEKVVKRV QEVSAVLYHI EVTEHPFKSK KMVWHKLLSK
     QRRRAVVACF RMTPLYNIIT HRATNMFLDA YKRNWLETEG YSFEDKMIDD LSKAMEEEEE
     EEEETERKPD PLHQLILHFS RTALTEKMKL DVDHLYMSYA DIMAKSCHIG EEDEGGEQEG
     EEPSFEEKEM EKQRLLYQQS RLHNRGAAEM VLQMISACKG EPGAMVSSTL KLGISILNGG
     NSDVQQKMLD YLKDKKDVGF FLSIQSLMQT CSVLDLNAFE RQNKAEGLGM VSEEGTNKKL
     ERDEKVMADD EFTCDLFRFL QLLCEGHNND FQNYLRTQTG STTTINVIIC TVDYLLRLQE
     SISDFYWYYS GKDIIDEPGK RNFSKAMNVA KQVFNSLTEY IQGPCTGNQQ SLAHSRLWDA
     VVGFLHVFAH MMMKLAQDSS QIGLLKELLD LQKDMVVMLL SLLEGNVVNG TIAKQMVDML
     VESSSNVEMI LKFFDMFLKL KDIVASDAFR DYVTDPRGLI SKKDFSKAMD SQKQYTPAEI
     QFLLSCSEAD ENEMINFEEF ADRFQEPAKD IGFNIAVLLT NLSEHVPHDT RLQNFLEQAE
     SVLNYFRPFL GRIEIMGASR KIERIYFEIS EANRNQWEMP QVRESKRQFI FDVVNEGGES
     EKMEMFVNFC EDTIFEMNIA ASISEPEGEA AEEEDDEEEE EGGGQEGEPA EGEEGNGEEH
     APESTSAFAD FLKSVVNFFN MFTFRNLRRR YRRFRKMTVK EMVIGLATFV YTVVMGILMF
     VYSICKGFFT LIWKVLFGGG LVESAKKMTV TDILASMPDP TQDEVHGELP PEPGSREDQD
     TEGGADLLDP VGGEEEEEDS EEREGGRLPG FNTPGGLGDF GETTPEEPPT PEGTPLLKRK
     LLAATVGGQG EEENAEHEEP PQETEKADTE NGEKAKKPEA EPEEEITVKA KAKKSKKPVE
     EGFELWNELE IQRVKFMNYL SRNFYNLRYL ALFIAFALNF ILLFYKVSDS PPGEEDFEGS
     GLFEGSGLFE GSGVQEDGSG LDDGGEDDDE EGPLYYFLEE STGYMEPAMA FLSIVHTIIS
     FLCIIGYNCL KVPLVIFKRE KELARKLEFD GVYVTEQPED DDIKGQWDRL VLNTPSFPNN
     YWDKFVKRKV LDKYGDIYGR ERIAELLGMD LASLDVSAMT HEKKPEPDTS MFSWITSIDI
     KYQIWKFGVV FTDNTFLYLV WYFLMSILGH YNNFFFAAHL LDIAMGVKTL RTILSSVTHN
     GKQLMMTVGL LAVVVYLYTV VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA
     GGGIGDEIED PAGDEYELYR VVFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVRED
     METKCFICGI GSDYFDTTPH GFETHTLEEH NLANYMFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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