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Database: UniProt
Entry: H2UT91_TAKRU
LinkDB: H2UT91_TAKRU
Original site: H2UT91_TAKRU 
ID   H2UT91_TAKRU            Unreviewed;      1423 AA.
AC   H2UT91;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   05-JUL-2017, entry version 35.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN8A (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000040164};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000040164};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000040164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000040164}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000040164}.
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DR   Ensembl; ENSTRUT00000040306; ENSTRUP00000040164; ENSTRUG00000015715.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20   1423       Sodium channel protein. {ECO:0000256|SAM:
FT                                SignalP}.
FT                                /FTId=PRO_5003574628.
FT   TRANSMEM    146    166       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    218    236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    257    284       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    443    461       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    481    502       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    523    551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    610    636       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    770    788       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    809    828       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    840    860       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    886    912       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1009   1035       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1090   1108       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1120   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1150   1170       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1207   1235       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1310   1333       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    291       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      418    640       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      685    732       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      768   1044       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1089   1343       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      281    315       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1423 AA;  161732 MW;  EA617A18D0D0390D CRC64;
     FSMIIMCTIL TNCIFMTFSD PPEWSKQASG FNVDPIWYTF TGIYTFESLV KITARGFCID
     NFTFLRDPWN WLDFMVISMA LPSYFLSHTT ALSSASLHTL KFVNLGNVSA LRTFRVLRAL
     KTISVIPGLK TIVGALIQSV KKLSDVMILT VFCLSVFALI GLQLFMGNLR QKCVFWPINI
     TDSQLSSQLD ALLCGNSSDS GRCPEGYTCM KAGRNPNYGY TSFDSFGWAF LALFRLMTQD
     FWENLYMLTL RAAGKTYMIF FVLVIFVGSF YLVNLILAVV AMAYEEQNQA TMEEAQQKEE
     EFKAMLEQLK RQQEEDAVED DGGGHLSCSS SEMSKLSSKS AKSRGCHGND SSVKCSGCRR
     CWLFLTGGAA TAASMGREIA QWIAMEWCHS SARGRVDAFC LSQCRCALPS AGHRWRSITI
     CIVLNTLFMA MEHYPMTPDF EHMLSVGNLV FTGIFAGEML FKLVAMDPYY YFQEAWNCFD
     GFIVTLSLVE LALADVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV
     LAIIVFIFAV VGMQLFGKNY KDCVCKIARD CELPRWHMND FFHSFLIVFR VLCGEWIETM
     WDCMEVAGQA MCLIVFMMVM VIGNLVVLNL FLALLLSSFS ADNLAATDDD GEPNNLQISV
     MRIKDLDYAK NGNGTTSGIG SSVGKYMIDE DHMSFIHNPN LTVCVPIAVG ESDFENLNTE
     DFSSESDIEN SKEVTCVAKY KCCEVDITMG WGKNWWFLRK TCYLIVEHNW FETLIIFMIL
     LSSGALAFED VYIEQRKTVR IILEYADRVF TYIFILEMLL KWVAYGFVKY FTNAWCWLDF
     FIVDVSIVSL VANALGYSDL GPIKSLRTLR ALRPLRALSR FEGMRVVVNA LVGAIPSIMN
     VLLVCLIFWL IFSIMGVNLF AGKYYFCFNE TSEEMFPVDV VNNKTQCEAL IHQNFTEVRW
     KNVKINFDNV GAGYLALLQV ATFKGWMDIM YAAVDSREVE DQPVYEVNIY MYIYFVVFII
     FGSFFTLNLF IGVIIDNFNQ QKKKDIFMTE EQKKYYNAMK KLGSKKPQKP IPRPQNKIQG
     MVFDFVTQQV FDISIMILIC LNMVTMMVET DDQSDETENV LYWVNFIFIV VFTTEFLLKL
     FALRHYYFTN GWNIFDVVVV ILSIVGMFLA DLIEKYFVSP TLFRVIRLAR IGRILRLIKG
     AKGIRTLLFA LMMSLPALFN IGLLLFLVMF IFSIFGMSNF GYVKHAVGID DLYNFETFGN
     SMIILFMITT SGGWDGLLLP ILNYPPDCDP NLENPGTSVK GDCGNPSVGI FFFVMYIIIS
     FLIVVNMYIA IILENFSVAT EESADPLSED DFETFYEIWE KFDPSASQFI TFTKLSDFAD
     ALEHPLRVPK PNTIELIAMD LPMVSGDRIH CLDILFAFTK RVL
//
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