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Database: UniProt
Entry: H2UWT6_TAKRU
LinkDB: H2UWT6_TAKRU
Original site: H2UWT6_TAKRU 
ID   H2UWT6_TAKRU            Unreviewed;      2086 AA.
AC   H2UWT6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101064574 {ECO:0000313|Ensembl:ENSTRUP00000041414};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041414, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000041414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000041414}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000041414}.
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DR   Ensembl; ENSTRUT00000041558; ENSTRUP00000041414; ENSTRUG00000016197.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    104    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    141    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    172    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    244    267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    357    379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    517       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    537    560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    629    648       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    696    718       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    873    891       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    911    931       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1018       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1141       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1192   1210       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1222   1245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1318   1336       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1410   1434       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1587   1621       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      729    752       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2086 AA;  234450 MW;  D2D56F1F5679CC5E CRC64;
     GLAPEHIPTP GAALSWQAAI DAARQAKMMG NAASSGGAGL GSGGGGPIST ASSTQRKRQH
     YSSKPKKPTT TTATRPPRAL LCLTLKNPIR RACISIVEWK PFEIIILMTI FANCVALAVY
     IPFPEDDSNA TNSNLERVEY LFLIIFTVEA FLKVIAYGLL FHPNAYLRNG WNLLDFIIVV
     VGLFSAILEQ ATKGDGATPI GGKAAGFDVK ALRAFRVLRP LRLVSGVPSL QVVLNSIIKA
     MVPLLHIALL VLFVIIIYAI IGLELFMGKM HKTCYYKQPK SLSEEKPAPC APEGAYGRHC
     KRNGTVCLME WDGPNDGITN FDNFAFAMLT VFQCITMEGW TDVLYWVNDA VGYEWPWLYF
     VTLIIIGSFF VLNLVLGVLS GEFSKEREKA KARGDFQKLR EKQQLEEDLK GYLDWITQAE
     DIDPENEEEG LDDDKPRNLS MPASENESVN TDNAPGGDVE GETCCTRLAN RISKSKFSRY
     SRRWNRLFRR KCRAGVKSQV FYWLVIFLVF LNTLTIASEH HHQPQWLTDV QDIANKVLLA
     LFTGEMLLKM YSLGLQAYFV SLFNRFDSFV VCGGILETIL VETKIMSPLG ISVLRCVRLL
     RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFEETRRS
     TFDNFPQSLL TVFQILTGED WNSVMYDGIM AYGGPAFPGM LVCIYFIILF ICGNYILLNV
     FLAIAVDNLA DAESLTSAQK EEEEEKERKK LARLASPEKR HNNEKPPLEE EKKEKIELKS
     ITSDGEANTA TKIHMDDYCG DDSEEKNPYP ANDYIGEDDE DEPEMPVGPR PRPLSDIQLK
     EKVVPMPEAR AFFVFSHTNK FRITCHKIVN HNIFTNLILF FILLSSISLA AEDPVKNDSS
     RNQILGYADH VFTGLFTIEI ILKMTAYGAF LHKGSFCRNY FNILDLVVVS VSLISSGIQS
     SAINVVKILR VLRVLRPLRA INRAKGLKHV VQCVFVAIRT IGNIVIVTTL LQFMFACIGV
     QLFKGKFFLC TDSSKQTQAE CRGSYIMYKD GDVGKPERAQ RLWENSEFNF DNVLQGMMAL
     FAVSTFEGWP GLLYRAIDSV AEDFGPIYNY RVIISIFFII YIIIIAFFMM NIFVGFVIVT
     FQEQGEQEYK NCELDKNQRQ CVEYALKARP LRRYIPKNPY QYKVWYVVNS TYFEYLMFTL
     ILLNTICLAM QHHGQTKSFN NAMNILNMLF TGLFTVEMIL KLIAFKPRHY FVDAWNTFDA
     LIVVGSIVDI AITENSEENA RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP
     YVALLIVMLF FIYAVIGMQM FGKIALRDNT QINRNNNFQT FPQAVLLLFR CATGEAWQEI
     MLACTLNRPC EKGSTNETNQ STEDCGSQFA IIYFVSFYML CAFLIINLFV AVIMDNFDYL
     TRDWSILGPH HLDEFKRIWA EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR
     LVSMNMPLNS DGTVMFNATL FALVRTALRI KTEGKTPMIT QVEHSLVFPP VAGNLEQANE
     ELRAIVKKIW KRTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQEYFRKFKK RKEQGLVAKV
     PPKTTLSLQA GLRTLHDIGP EIRRAISGDL TVEEELDKGL KEPVSAASED DIFRRTGGLF
     SNHVNYYNQS DGRSSFPQSF TTQRPLHISQ KGSPCEAESP SHEKLMDSTT FTPSSYSSSG
     SNANINNANN TSVGGVTTQG ISRYPSPSIS TVDGHTGQPL TPILLPKSSW CFPPKRCHSV
     DSRLPIIRRG EGSMEETYDE SYTDDREYQE DNHSLSSDML VYHDETCKQL TPMEEGEEVE
     HRRGGVWQSP RRVFLCPTSL VRRSSFHLEC LRRQSRPDVS QKTAVPLHLV HHQALAVAGL
     SPQLRRSHSP TLFSRLCSTP PASPTAHGSG ASYQQVPSLR LEGSNSHEKL NTSLPSVNCG
     PCRVPSPSPS VSVSAQRPAR PLSLTVPSLL GKDNSSLTHG SAGSLVEAVL ISEGLGEFAQ
     DPSFIEVTKA ELADACEMTI EEMEQAANNI LNGNTTHSPN GNFLPF
//
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