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Database: UniProt
Entry: H2UWU0_TAKRU
LinkDB: H2UWU0_TAKRU
Original site: H2UWU0_TAKRU 
ID   H2UWU0_TAKRU            Unreviewed;      1841 AA.
AC   H2UWU0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101064574 {ECO:0000313|Ensembl:ENSTRUP00000041418};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041418, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000041418}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000041418}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000041418}.
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DR   Ensembl; ENSTRUT00000041562; ENSTRUP00000041418; ENSTRUG00000016197.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     58     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     95    114       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    126    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    198    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    311    333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    425    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    485       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    554    573       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    798    816       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    836    856       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    914    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1037   1066       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1117   1135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1147   1168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1265   1288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1357   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1515   1549       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      654    677       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1841 AA;  208565 MW;  85BA5FB5C9C6047D CRC64;
     PISTASSTQR KRQHYSSKPK KPTTTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII
     LMTIFANCVA LAVYIPFPED DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY
     LRNGWNLLDF IIVVVGLFSA ILEQATKGDG ATPIGGKAAG FDVKALRAFR VLRPLRLVSG
     VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYY KQPKSLSEEK
     PAPCAPEGAY GRHCKRNGTV CLMEWDGPND GITNFDNFAF AMLTVFQCIT MEGWTDVLYW
     VNDAVGYEWP WLYFVTLIII GSFFVLNLVL GVLSGEFSKE REKAKARGDF QKLREKQQLE
     EDLKGYLDWI TQAEDIDPEN EEEGLDDDKP RNRECLMLFV SFHRYSRRWN RLFRRKCRAG
     VKSQVFYWLV IFLVFLNTLT IASEHHHQPQ WLTDVQDIAN KVLLALFTGE MLLKMYSLGL
     QAYFVSLFNR FDSFVVCGGI LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL
     VASLLNSVRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFE ETRRSTFDNF PQSLLTVFQI
     LTGEDWNSVM YDGIMAYGGP AFPGMLVCIY FIILFICGNY ILLNVFLAIA VDNLADAESL
     TSAQKEEEEE KERKKLARLA SPEKRHNNEK PPLEEEKKEK IELKSITSDG EANTATKIHM
     DDYCGDDSEE KNPYPANDYI GEDDEDEPEM PVGPRPRPLS DIQLKEKVVP MPEARAFFVF
     SHTNKFRITC HKIVNHNIFT NLILFFILLS SISLAAEDPV KNDSSRNQIL GYADHVFTGL
     FTIEIILKMT AYGAFLHKGS FCRNYFNILD LVVVSVSLIS SGIQSSAINV VKILRVLRVL
     RPLRAINRAK GLKHVVQCVF VAIRTIGNIV IVTTLLQFMF ACIGVQLFKG KFFLCTDSSK
     QTQAECRGSY IMYKDGDVGK PERAQRLWEN SEFNFDNVLQ GMMALFAVST FEGWPGLLYR
     AIDSVAEDFG PIYNYRVIIS IFFIIYIIII AFFMMNIFVG FVIVTFQEQG EQEYKNCELD
     KNQRQCVEYA LKARPLRRYI PKNPYQYKVW YVVNSTYFEY LMFTLILLNT ICLAMQHHGQ
     TKSFNNAMNI LNMLFTGLFT VEMILKLIAF KPRGYFSDPW NVFDFLIVIG SIIDVILSEI
     NLSTRSSHGQ WCDGPHCGVV VNSEENARIS ITFFRLFRVM RLVKLLSRGE GIRTLLWTFI
     KSFQALPYVA LLIVMLFFIY AVIGMQMFGK IALRDNTQIN RNNNFQTFPQ AVLLLFRCAT
     GEAWQEIMLA CTLNRPCEKG STNETNQSTE DCGSQFAIIY FVSFYMLCAF LIINLFVAVI
     MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKLCP
     HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE GNLEQANEEL RAIVKKIWKR
     TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ EYFRKFKKRK EQGLVAKVPP KTTLSLQAGL
     RTLHDIGPEI RRAISGDLTV EEELDKGLKE PVSAASEDDI FRRTGGLFSN HVNYYNQSDG
     RSSFPQSFTT QRPLHISQKG SPCEAESPSH EKLMDSTTFT PSSYSSSGSN ANINNANNTS
     VGGVTTQGIS RYPSPSISTV DGHTGLSHAV CCQGSQTEFV CAEINANVTQ PRAPLLFVDV
     LLNSLPPPPL SPPPGSGSRR VESSGQQLAD SRQRRQSGGS VPRRVISNQI MFHLLVLQVL
     ISEGLGEFAQ DPSFIEVTKA ELADACEMTI EEMEQAANNI L
//
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