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Database: UniProt
Entry: H2UXQ0_TAKRU
LinkDB: H2UXQ0_TAKRU
Original site: H2UXQ0_TAKRU 
ID   H2UXQ0_TAKRU            Unreviewed;       916 AA.
AC   H2UXQ0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 5 {ECO:0000313|Ensembl:ENSTRUP00000041729};
GN   Name=trpm5 {ECO:0000313|Ensembl:ENSTRUP00000041729};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041729, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000041729}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000041729}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000041729}.
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DR   Ensembl; ENSTRUT00000041873; ENSTRUP00000041729; ENSTRUG00000016316.
DR   GeneTree; ENSGT00760000119127; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029577; TRPM5.
DR   PANTHER; PTHR13800:SF5; PTHR13800:SF5; 2.
DR   Pfam; PF00520; Ion_trans; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    520    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    560    585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    729       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    783    808       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      575    819       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   916 AA;  105334 MW;  53F6D60CCB0DF237 CRC64;
     TKHLGQAVRD HSLASTSSKV RVVAIGIAPW NMIHNREALL SAKVDEPASY KPQDLPHGSV
     YSLDSHHSHF VLVEEDPNRL GATSEMRVKL LKHISLQRTA YGGTGSFEIP VLCLLVHGEP
     RILKRMYKGI GNSTPWLILA GSGGVADILV TLMNRGCWDV DSVQELLLDT FPNAHHSTDI
     SNWVKLIQKI LDHGHLLTVH DPEQETSELD TVILKALVKA CKSQSQEAQD FLDELKLAVA
     WNRVDIAKSD IFNGDVDWKA CDLEEVMMDA LINDKPDFVR LFVDNGVNLG EFLTYGRLQK
     LYWSVSEKSL LHNLLLKKTA RAPGPPGHHP SEQGDRKPRF TLFEVAKVLK DFLHDSCKGF
     YQKTPTEKPA KGRLFHTQKN LAELEERCEH PWRDLFLWAV LQNRQQMANY FWAMGPEAVA
     AALAGCKILK EMARLESEAE SARSMKEAKY EQFALDVFGE CYSNSEDRAY VLLVRRTKCW
     SKSTVLNLAT EADAKSFFAH DGVQALLTKI WWGSMTTDTA ISKLVVSFFW PPLIWTNLIK
     FRNDIKLDSQ EEPRWRWHRF WSAPVTVFLG NVIMYFAFLF LFTYVLLLDF RPPPPFGPGV
     PELMLYFWVF SLVLEELRQG FFTDEEMSIS KKFKLYVEDN WNKCDMVAIS LFVVGVVCRM
     LKDTYEAGRT VLAIDFMVFT LRLIHIFAIH KQLGPKIIIV ERMMKDVFFF LFFLSVWLIA
     YGVATQALLH PNDPRIDWVF RRALYRPYLH IFGQIPLEEI DVNCTNDSEE IIQGLRPPCP
     NIYANWLVIL LLVIFLLVTN VLLLNLLIAM FSYTFQVVQG NTDIFWKFQR YNLIVEYYSR
     PALAPPFIII SHLSQLLLSL VKHPDSKHEH LEKELPVGLD QRLITWETVQ KENYLAKLER
     QHWESSEEKL KSTSSK
//
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