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Database: UniProt
Entry: H2UXX8_TAKRU
LinkDB: H2UXX8_TAKRU
Original site: H2UXX8_TAKRU 
ID   H2UXX8_TAKRU            Unreviewed;       619 AA.
AC   H2UXX8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Potassium voltage-gated channel, KQT-like subfamily, member 1 {ECO:0000313|Ensembl:ENSTRUP00000041807};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000041807, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000041807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000041807}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000041807}.
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DR   ProteinModelPortal; H2UXX8; -.
DR   STRING; 31033.ENSTRUP00000041807; -.
DR   Ensembl; ENSTRUT00000041951; ENSTRUP00000041807; ENSTRUG00000016351.
DR   eggNOG; KOG1419; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00550000074513; -.
DR   InParanoid; H2UXX8; -.
DR   OrthoDB; EOG091G02ZT; -.
DR   TreeFam; TF315186; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0097205; P:renal filtration; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF109; PTHR11537:SF109; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01460; KCNQ1CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    161    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    202    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    266    287       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    356       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    357       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      505    589       KCNQ_channel. {ECO:0000259|Pfam:PF03520}.
SQ   SEQUENCE   619 AA;  69407 MW;  CC177E768C2040F4 CRC64;
     AQKGTKTQEI RVGKQNGNIA AQPKLLHFGG TAKSSHGKPP LDLQLSEIGP GAPDVEPPAR
     NDGRKMPADA TANSEVPPAY LHPYSAHPRM SFRMSVYSTG VRPVLTRAYI QGRVYNFLER
     PSGWKCLLYH FTVFLIVLAC LILSVLSTID QYQSLSQTTL FWVEIVLVVF FGMEYFIRLW
     SAGCRSKYVG VWGRLRFARK PISIIDLIVV VASVIVLSVG SKGQVFATSA VRGIRFLQIL
     RMLHVDRQGG TWRLLGSVVY IHRQELITTL YIGFLSLIFS SYFVYLAETY AISGGSTEFR
     NYADALWWGV VTVTTIGYGD KVPQTWIGKT IASCFSVFAI SFFALPAGIL GSGFALKVQQ
     KQRQKHFNRQ IPAAAGLIQT SWRCFAVENL DSATYKMFLR KRSNITASSL SSPKSKKSVK
     IKRKPKSADQ DNGPTSPTVP SITYDSVFDS GRELRSPAVV DVFELSPVRR SPGLLDVHGH
     DPLRRNASFA NDTELESEHH NHLFPAASLS QLTESHRKAI RVIQRMRYLV AKRNFQQARK
     PYDVRDVIEQ YSQGHLNLMV RIKELQRRLD QSLGKMTLFQ AGSERAKDRG NNSIGSRLNR
     MEDKISHMDQ TLGRISESL
//
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