ID H2UZ90_TAKRU Unreviewed; 532 AA.
AC H2UZ90;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Bardet-Biedl syndrome 4 {ECO:0000313|Ensembl:ENSTRUP00000042269.2};
GN Name=bbs4 {ECO:0000313|Ensembl:ENSTRUP00000042269.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042269.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042269.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042269.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}.
CC -!- SIMILARITY: Belongs to the BBS4 family.
CC {ECO:0000256|ARBA:ARBA00023778}.
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DR RefSeq; XP_003969849.1; XM_003969800.2.
DR AlphaFoldDB; H2UZ90; -.
DR STRING; 31033.ENSTRUP00000085935; -.
DR Ensembl; ENSTRUT00000042413.3; ENSTRUP00000042269.2; ENSTRUG00000016534.3.
DR GeneID; 101073911; -.
DR KEGG; tru:101073911; -.
DR CTD; 585; -.
DR GeneTree; ENSGT00940000158166; -.
DR OrthoDB; 5481067at2759; -.
DR Proteomes; UP000005226; Chromosome 13.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44186; -; 1.
DR PANTHER; PTHR44186:SF1; BARDET-BIEDL SYNDROME 4 PROTEIN; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 166..199
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 200..233
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 302..335
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 336..369
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..516
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 59347 MW; 1331B79CD769CE76 CRC64;
MAEEEKSAVL PAATETKKRR APKAPELPIV ERRNWLIHQH YVRKDYDTCK MIIKEQLQET
TGMCEYAIYV QALILRLEGK IQESLELFQS CAILNPSSSD NLKQVARSLF LLGKHKAAIE
FYHEAARVTD KDWEISHNLG LCYFFIKDLK NAEEHLNRAL QINKHDKTFM MLGKVHLLAG
DTDKAIDVYK RAVEFSPENT EVLTTLGLLY LQLGKYQKAF EHLGNALTFD PSNYKAILAA
GSMMQTHGDF DVAMNKYRVA ACVVPESPPL WNNIGMCFFG KKKYVAAFSC LKRAHYLSPF
DWKVLYNLGL VHLTMQQYAS AFHFLSAAIN LNPRMGELYM LLAVALTNLE DVENATKAYE
QAVTMDDSNP LVNLNFAIFL YNHGEKEEAL AQYQEMERKV NLLRDSNSNF EFDAELIDMA
QKMGGALQVT DSLVWTKPDK DSKSKSTSSV ASKGPSAPLG TNQALGQAMS SAASYNKNIT
LPAGVSEGSS LPLEPEGDVE KAPSPPTEPP GSPEPAESAK PRTSKKKSKV EA
//
