ID H2UZL6_TAKRU Unreviewed; 624 AA.
AC H2UZL6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Receptor like tyrosine kinase {ECO:0000313|Ensembl:ENSTRUP00000042395.3};
GN Name=ryk {ECO:0000313|Ensembl:ENSTRUP00000042395.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042395.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042395.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042395.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2UZL6; -.
DR STRING; 31033.ENSTRUP00000042395; -.
DR Ensembl; ENSTRUT00000042539.3; ENSTRUP00000042395.3; ENSTRUG00000016581.3.
DR eggNOG; KOG1024; Eukaryota.
DR GeneTree; ENSGT00940000155119; -.
DR InParanoid; H2UZL6; -.
DR OMA; CWAMSPD; -.
DR OrthoDB; 1614410at2759; -.
DR TreeFam; TF317402; -.
DR Proteomes; UP000005226; Chromosome 20.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:Ensembl.
DR GO; GO:0060028; P:convergent extension involved in axis elongation; IEA:Ensembl.
DR GO; GO:0060030; P:dorsal convergence; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0007223; P:Wnt signaling pathway, calcium modulating pathway; IEA:Ensembl.
DR CDD; cd05043; PTK_Ryk; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.60.40.2170; Wnt, WIF domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR003306; WIF.
DR InterPro; IPR038677; WIF_sf.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416:SF349; TYROSINE-PROTEIN KINASE RYK; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF02019; WIF; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00469; WIF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50814; WIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..624
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172460"
FT TRANSMEM 217..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..181
FT /note="WIF"
FT /evidence="ECO:0000259|PROSITE:PS50814"
FT DOMAIN 347..620
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 624 AA; 70425 MW; 2252741E2F559742 CRC64;
MSVPNFAQTA EPRRWPHSML WKLASFIFLI LLKGIDCLAN PSYLPDNYNP SVNIYMSLEE
VKKLLGLDAE LYYVRNNVVN HYALSFTLPV PSETNSLHFT WHSKTKVGYK LGFHTENPDA
MSQPRSNIST QGEVPHIPSV FRVDLVCSGK VDGEAVLTVQ LNLTTHTSNY MVLNFKRRKM
CYKKSDSDMN IPSPFNNNTL PRTDFEGVIA PTTSTQVFYI SVSVCCIVIF LVAIFLAIMH
LHSMKRMEME DSMSDSGSSQ GLSQPSTHTT QYLRADTPNN VAPVTSNHQA SAPILQLAAT
TFHNIGASPH ETKNHPSLHI EKNDLKSVTL LEAKVKVKDI AVSRERVTLR DVLHEGTFGQ
IFQGALLDEK DPSKEKQVFV KTVKDHASEV QITMMLTESC KLRGLHHRNL LPINHVCTED
GEKPMVLLPF MAWGNLKLFL RQCKLAEANN PQSISQQDLV YMAIQIACGM SYLSRREVIH
KDLAARNCVI DDNMQVKITD NALARDLFPM DYHCLGDNEN RPVRWMALES LLNNDFSSLS
DVWAFGVTLW ELMTLGQTPY VDIDPFEMSA YLKDGYRIAQ PINCPDELFA VMACCWALDP
EERPKFQQLV QCLTEFHSAL GAYV
//
