ID H2V0I7_TAKRU Unreviewed; 819 AA.
AC H2V0I7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Neural EGFL like 2 {ECO:0000313|Ensembl:ENSTRUP00000042717.3};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSTRUP00000042717.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042717.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042717.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042717.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H2V0I7; -.
DR STRING; 31033.ENSTRUP00000080179; -.
DR Ensembl; ENSTRUT00000042861.3; ENSTRUP00000042717.3; ENSTRUG00000016697.3.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00810000125439; -.
DR TreeFam; TF323325; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 4.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 55..226
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 270..329
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 439..480
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 522..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..589
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 601..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 637..692
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 697..755
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DISULFID 524..534
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 542..551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 819 AA; 90740 MW; B9F68E8976DE6124 CRC64;
LEHWLYIKKK KIITELFLGF GVDPALRISV FDELTLGEGF DGVTQVQGFH SESRAFHFQG
SSREVVAPTD VSEHMIRKLR GKNEFTVLVT LKQDHLNSGV VLSIHHSEHR FLELESSGQR
SEVRLHYRTR GQQAHTEVFP YSLADDQWHK VSVAVSASHV ILHVDCNRIY ERVVEAPYMD
IPEDASFWLG QRNAAHGFFK GVMQDVEILV MPQGYISQCP DLNRTCPTCN DFHGLVQKIM
ELQDVLAKTS SKLSRAEEKM NGLEGCYCER TCSVKGVIYR EDEGWTDGCR NCTCSNGTVQ
CEAISCPPPQ CPAGTAPAYV KGACCKECQP LCLFGGRELV EGDQKAVHDS SGRCLLFECR
DRTMHRLAPS EPCPELDCAE SEQIVLNDRC CKVCRGHDFC SEGHGCMEHS DCVNLEAGGC
CACKDGFRPL RDDNAYCEDI DECAEGKHYC RENTMCVNTP GSFMCICHTG YIRIDDYSCT
EHDECLSGQH NCDKNALCFN MVGGHSCSCK PGYTGNGTVC KAMCDGLCQN GGTCVSPNNC
VCQQGFTGKR CETDIDECAD GFVECDSKST CVNLPGWYHC ECRDGYHDNG LFSTNGESCV
DINECKTGRN TCANDTVCFN LDGGYDCRCP HGHNCTGDCI HDGKVKHSGQ IWVLDSDRCS
VCSCQAGQVM CRRMVCDCDN PNADLFCCPE CDPRLSSQCM HQNGLLTYGS GDTWVENCQQ
CQCLQGQVDC WPLPCPPVDC EFTVVPEGEC CPRCITDPCQ ADTIRNDITK TCTDEHSISR
FSGSSWIKHG TECTLCQCKV SFQYTPLRSG LGSSGIRKH
//
