ID H2V187_TAKRU Unreviewed; 643 AA.
AC H2V187;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Calpain-5-like {ECO:0000313|Ensembl:ENSTRUP00000042967.1};
GN Name=LOC101077726 {ECO:0000313|Ensembl:ENSTRUP00000042967.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000042967.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000042967.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000042967.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR RefSeq; XP_003971307.1; XM_003971258.2.
DR RefSeq; XP_011609876.1; XM_011611574.1.
DR AlphaFoldDB; H2V187; -.
DR STRING; 31033.ENSTRUP00000058269; -.
DR Ensembl; ENSTRUT00000043112.3; ENSTRUP00000042967.1; ENSTRUG00000016780.3.
DR GeneID; 101077726; -.
DR KEGG; tru:101077726; -.
DR eggNOG; KOG0045; Eukaryota.
DR GeneTree; ENSGT00940000156128; -.
DR HOGENOM; CLU_010982_3_2_1; -.
DR OMA; SIHKTWH; -.
DR OrthoDB; 142935at2759; -.
DR TreeFam; TF314748; -.
DR Proteomes; UP000005226; Chromosome 15.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04046; C2_Calpain; 1.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033884; C2_Calpain.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF381; CALPAIN-6; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 26..342
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT DOMAIN 500..617
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 251
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 283
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 643 AA; 72891 MW; 2D6C41D2C989C34E CRC64;
MFSSAAPYKN QHYHDLKKDC IKDQKLFEDP EFPATSSSLY FRKPPPGFVE WKRPGEICQE
PYLFVEGISS HDLNQGVVGN CWFVAACSCL ALKPNLWKKV IPDHKEQEWD HKHPAEYAGI
FHFQFWVFGE WVDVVVDDRL PTINGELIYC HSKENNEFWS ALVEKAYAKL AGCYESLEGG
NTGDAVVDFS GAVSELVSLE EGAFYKDQKK EEQLFEDLLK VYDRGGIISC SIKAEPHEIE
LKMSNGLVKG HAYSVTAVKK VRLGHGLLAY FQNETIPLIR MRNPWGKTEW KGAWSDSSEE
WSKVGDTERG NLGITVADDG EFWMSFTDWC KFFTEADVCR LINTSMISVH KTWHEVVHFG
SWTKNAEPLL NRCGGCSNHR QTFLQNPQYL FDITKEADEV LISLQQKDLK SLRKVGQGEN
LTIGFSVFKV ELNRKYRMHD ILTQESVVTS TYINARSVFL RATLPLGRYI IFPTTFRPLT
LGDFMLRVFT DVESGCRELI QDKPKIKCWS SFFGYPQVVT HVYVHGAEGL QNQDSSGGAD
PYVIIHCEGQ SVRSTIKTDT LQPEFKTSGV FYRKKPRKPI TVEVWNSNAV KDEFMGQVVL
SGSLKDSSGP QKLQLRKGGR NAADEMPGTI GLRIVTATQL TVI
//
