GenomeNet

Database: UniProt
Entry: H2V2J5_TAKRU
LinkDB: H2V2J5_TAKRU
Original site: H2V2J5_TAKRU 
ID   H2V2J5_TAKRU            Unreviewed;      5085 AA.
AC   H2V2J5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSTRUP00000043426};
GN   Name=LOC101072939 {ECO:0000313|Ensembl:ENSTRUP00000043426};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043426, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000043426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000043426}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000043426}.
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DR   STRING; 31033.ENSTRUP00000043426; -.
DR   Ensembl; ENSTRUT00000043571; ENSTRUP00000043426; ENSTRUG00000016954.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2V2J5; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4370   4393       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4600   4620       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4690   4711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4828   4849       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4887   4907       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4966   4989       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      279    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    803       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1019   1215       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1353   1563       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   5085 AA;  576439 MW;  B979E2BB6E343E5F CRC64;
     MAEGADGEEE IQFLRTGDHV VLQCTASILK EQIKVCLSCE GFGNRLCFLE TTSNAQSVPP
     DLAICCFILE QSLSVRALQE MLSNTSLDEA VDLDKWSSQG GGHRTLLYGH AILLRHTHSS
     MYLSCLTTSR SLTDKLAFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS
     SERYLHLSYA SGDLMVDASF MQTLWTMTPV MSGCELAEGF LSGGYVLRLF HGHMDECLAI
     PGAEQGDDQR RVVHYEGGAV CSHARSLWRL EPLRIGWSGS HIKWGQSFRI RHITTGRYLF
     LDEDKGLLLV DAEKANSKMS AFCFRISKEK IEVAQKRDVE GMGTPEIKYG ESMCFVQHVS
     SGLWLTYAAV DAKSARLGPL KRKAILHKEG HMDDALTVAR SQTEESQAAR MIYSTTGLFN
     QFIKGLDALS GKNKSANPPS LPMDAVVLSL QDLIFYFRPP EEELEHEEKQ FKLRSLKNRQ
     NLFQEEGMIT LVLDCVDRLN VYNTAAHFSE YAGEEAAESW KEIVNLLYEL LASLIRGNRA
     NCALFCDNLD WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR
     NHKVLDVLCS LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIINYATSMR PNIFLGTCEG
     STQYKKWYFE VMVDHVEPFL TAQPYHLRVG WALTEGYSPY PGGGEGWGGN GVGDDLYSYG
     FDGLHLWSGR VPRHVASPNQ HILTAEDVVS CCLDLSVPSI SFRINGHPVR GMFENFNLDG
     LFFPVVSFSA GVTIRFLLGG RHGDFKFLPP PGYAPCYEAV LPRDRLRIEP IKEYKHDFED
     VRNLLGPTQS LSHTAFTPCP VDTIQIVLPP HLERIREKLA ENSHELWAVT RIEQGWTYGP
     FRDDNKKLHP CLVDFQSLPE PEKNYNLAMS GETLKTLLAL GCHVGMGDEK AEENLKKIKL
     PKTYMQTSGY KPAPLDLNHV KLTPNQNTLV ERLAENGHNV WARDRVRQGW TYSIVQDIVN
     RRNPRLVPYN LLDEKTKKTN RDTVCSAVRT LIGYGYNIEP PDQESSADGP GSPRGDKIRV
     FRAEKSYAIT QGKWYFEFEA VTVGEMRVGW ARPSVRADTE LGGDELAYVF NGFKAQRWHM
     GMESFGRQWQ SGDVVGCMID LTEMNIMFTL NGEMLISDSG SEMAFKDIEI GEGFIPVCSL
     GLSQVGRINL GQNVSSLRYF TICGLQEGFE PFAINMKRDI TMWFSKSLPQ FMNAPTDHPH
     VEVTRVDGTV ETPPCLKVTH KTFGSQNANT DLLFFRLSMP IEFHETFKVP AGTTLLTRAM
     TIPEEDVVEV DPDSDFEILK KSATRKEQEE DKKEPSVPKE IPAIKNGENE KDASTEKSKK
     KGFLFKAKKA ALINPPPVVP TMPRLVEDVV PDDRDDVDII LNTTTYYYSV RVFAGQEPSG
     IWVGWITPDY HQYDLHFDIN KVRNVTVTVG DDKGNIHDSI KRSNCYMVWG GEFSNSQQTR
     VSQEDFIIGC LVDLDTGLMT FTANGKEINT FYQVEPNTKL FPAVFVLPSS QNMIQFELGK
     LKNIMPISAA MFRSERKNTV PQCPPRLDVQ MLTPVIWSRM PNHFLAPETG RVSERLGWIV
     QCHEPLTMMA LHISEENRCI DILELSERMD LLKFHYHTLK LYGSVCALGN NRVAHALCSH
     VDESQLFYAI QNTYLPGPIR SGFYDLLISM HLESAKRGRL GTNREFIIPM TDETRSITLY
     TDKSCALPGV GLTTCLRPKL HFSSVGFVGT NQDIYTLSPV IPLQVLKTRA LNMLTEAVQD
     GVQAMRDPVG GSVEFHFVPI LKLISTLLIM GVFDDEDVTH ILKMLEPTVF SGKKEEEPAE
     ENGETKEQKE QEVPQQAGAV GEQHQEAMEE EEEEFEEEEF EDDGLGEEEE EEEMEQEEVE
     STKALVPQEE HKEETERVSG EKGAQETEKE KHLETSGESE ESLEEGLFQM KLPESVKLQM
     CTLLQYFCDC ELRHRVEAII AFSDMFVSQI QSNQRQRYNE LMLAFTMSAA ETARKTREFR
     SPPQEQVNML MNFKNCAEDE ECPIPDEVRE SMLIFHNALL THCGVHIDEE EEEQEVDNSL
     RGRLVRLLER VKKFREKKVE VQLEPQEDKK PSTLQELISH TTIHWAQESF IQNPELVRMM
     FSLLHRQYDG LGELIRALPK AYTINAVSII DTMDLLECLG QIRSLLIVQM GPEEERLMIQ
     SIGNIMSNKV FYQHPNLMRA LGMHETVMEV MVNVLGGGDS KQEIRFPRVV TNCCRFLCYF
     CRISRQNQRS MFDHLSYLLQ NSGIGLGMRG STPLDVAAAS CIDNNELALA LQEQDLEMVV
     KYLAGCGLQS CPMLLAKGYP DIGWNPCGGE KYLDFLRFAV FVNGESVEEN ANVVVRLLIR
     RPECFGPALR GEGGNGLLAA IEEAIKISED PARDGPTTKK DRRFPMFGGE EQHEENRVHL
     GNAIMSFYSA LIDLLGRCAP EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLPVQIPS
     FGKDNSIIEP KMSASFVPDH KAPMVLFLDR VYGIDNQDFL LHVLEVGFLP DMRAAASLDT
     VAFSTTEMAL ALNRYLCSAV LPLITKCAPL FAGSDHRAIM IDSMLHTIYR LSRGRAFTKA
     QRDIIEECLM ALCKHLRPSM LQHLLRRLVF DVPILNEYAK MPLKLLTNHY ERCWKYYCLP
     NGWANFGVAS EEELHLTRKL FWGIFESLAH KKFDAEIFKI SMPCLCAIAG AIPPDYVDAS
     YSSKTEKKAS VDAEGNFDPK PVDTTNTIIP ERLDAFINRY AEYTHDKWAF EKIQNNWSYG
     ETLDENAKTH PMLRPYKTFS EKDKEIYRWP IKESIKAMIA WEWNIDKARD EEESEKKKAA
     ARKISQTAQA TYDPSHGYSP QPIDITHMAL SRDLQSMAEQ LAENYHNTWG RKKKLELQSK
     GGGTHPLLVP YDTLTAKEKA RDREKAYELL KFLQLNGYAV TRGLKDMESD ISSIEKRFAY
     GFLQKLLKWM EIAQEFIAHL EAVVSSGRVE KSPHEQEIKF FAKILMPLIN QYFKNHCLYF
     LSTPAKVLGS GGHSSNKEKE MIASIFCKMS ALVRHRVSLF GTDASAIVNC LHILARSLDA
     RTVMKSGPEI VKAGLRSFFE SAADDIEKMV ENLKLGKVSK GNQQVKGVSQ NINYTTIALL
     PVLTSLFDHI AQHLFGDDVI LDDLQMSCYR IMCSIYSLGT VKNPHVERQR PALGECLAHL
     AAAMPVAYLE PHLNEFNAFS VYTTKTPRER AILGLPNEVQ ELCPDIPELD VLLKEIGDLA
     ESGARYTEMP HVIEITLPML CNYLPRWWER GPENFPEMES KICTDVTSEH LNQLLGSIMK
     IVVNNLGIDE ASWMKRLAVF SQPIVSRAKP EMLKSHFIPT MEKLKKRTSK VVAEEDHLRM
     EGKTEADEED GTIRDEFAVL CRDLYALYPL LIRYIDNNRA RWLTCPDPDA EELFRMVGEV
     FIFWSKSHNF KREEQNFVVM NEINNMSFLT ADSKSKMSKG GDSEGGGSDT ERTKKKKRGD
     RYSVQTSLIV AALKKMLPIG LNMCSPADQE LINLAKIRYS LRDTDEEVRE FLQNNLHLQG
     KVDNPSMRWQ MALYKEMAGK AEDADAPVKV VKRVQEVSAV LYHLEVTEHP FKSKKMVWHK
     LLSKQRRRAV VACFRMTPLY NIPRHRASNM FLEGYKRNWL YTEGYAFEDR MIDDLSKAME
     QEEGDEEEEK ETKPDPLHQL ILHFSRTALT EKSKLDTDHL YMAYADIMAK SCHIDEEEEG
     GEEMVENDED EKSFEEKEME KQRLLYQQSR LHNRGAAEMV LQMISACKEL GETGPMVTTT
     LKLGISILNG GNSEVQRKML EYLKDKKDVG FFLSVQALMQ TCSVLDLNAF ERQNKAEGLG
     MVSEEGTSEK VMADDEFTCD LFRFLQLLCE GHNNDFQNYL RTQIGSTTTI NIIICTVDYL
     LRLQESISDF YWYYSGKDVI DDPGKKNFSK AMTVAKQIFN TLTEYIQGPC TGNQQSLAHS
     RLWDAIVGFL HVFAHMMMKL AQGKDSSQIG LLKELLDLQK DMVVMLLSLL EGNVVNGTIA
     RQMVDMLVES SSNVEMILKF FDMFLKLKDI VASDAFRDYV TDPRGLISKK DFQKAMDSQK
     QYSPSEIQFL LSCSEADEND MIHYEEFASR FQAPAKDIGF NIAVLLTNLS EHVPHDTRLQ
     NFLEQADSVL NYFRPFLGRI EIMGASRKIE RIYFEISEVN RRQWEMPQVR ESKRQFIFDV
     VNEGGESEKM EMFVNFCEDT IFEMNIASQI SEQEEEEKGE EDDEGEDAGG EGGPGAGVSG
     GGDEDSNGEE GQPESSSAFA EFINSTISFF SIFTFRNLRR QYRRVRKMTI KEIIVALSTF
     FWTILMSILH FIYSVCKGFF MIIWQALFGG GLVEGAKNIT VTEILASMPD PTQDDVHGDG
     PGEPRMGEEQ DPGGVTESGE TGSGEEEEED TQDKEGGRIP GIDAPGGLGD MGVESPVEPP
     TPEGTPITKR KKAPDETDAS QKPPEPVPVE EPPPEPEKAE VESGEKAEKE PQSNEEQLEK
     PKKSAQKKEK KVKGAEGFQI WGELETQRNK FLNYLSRNFY NLRFLALFLA FALNFILLFY
     KVSDTPPEGE ELEGSGLSEG SGMFEASGLF EGSGEEAEGS GMSDGGDEND EDMPIYFYLE
     ESTGYMQPTL AFLAALHTVI SFICIIGYNC LKIPLVIFKR EKELARKLEF DGLYITEQPE
     EDDIKGQWDR LVLNTPSFPN NYWDKFVKTK VLDKYGDIYG RERIAELLGV DLASLDVSQQ
     HEKKQEAPDN SVFAWITSID MKYQIWKFGV VFTDGTFLYL CWYTIMSLLG HYNNFFFACH
     LLDIAMGVKT LRTILSSVTH NGKQLMMTVG LLAVVVYLYT VVAFNFFRKF YNKSEDEDEP
     DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDEYELY RVVFDITFFF FVIVILLAII
     QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGSDYFDTTP HGFETHTLDE HNLANYMFFL
     MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLS
//
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