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Database: UniProt
Entry: H2V3I5_TAKRU
LinkDB: H2V3I5_TAKRU
Original site: H2V3I5_TAKRU 
ID   H2V3I5_TAKRU            Unreviewed;       903 AA.
AC   H2V3I5;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 6a {ECO:0000313|Ensembl:ENSTRUP00000043767};
GN   Name=LOC101068175 {ECO:0000313|Ensembl:ENSTRUP00000043767};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043767, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000043767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000043767}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000043767}.
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DR   ProteinModelPortal; H2V3I5; -.
DR   STRING; 31033.ENSTRUP00000043767; -.
DR   Ensembl; ENSTRUT00000043913; ENSTRUP00000043767; ENSTRUG00000017086.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; H2V3I5; -.
DR   OMA; NRGPAYM; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    398    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    430    453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    529    548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    560    580       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    592    613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    633    655       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    676    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    704    723       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    240       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT      208    240       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
SQ   SEQUENCE   903 AA;  102273 MW;  B31485BB6C123448 CRC64;
     LASRMNHRPP AGHSNRPPAG YSDSPRARSR DNLLMCNDFG EENCCSGRCL GNSSSDRQLL
     ARLCAVKRRQ ALRGPAYMFS APSYSLSEVE QRFLEAAEYG NIPEVRRMLL HVPNLNINAV
     DYMGQNALQL AVANEHLEVT ELLLGRADLA RVGDALLLAI SKGYIRITEA LLSHPAFRDA
     RRLTASPAQA DMLDDFYAYD EDGTRFSHDV TPLILAAHCQ EYEIVHTLLS KGARIDHPHD
     YFCGCDSCNY QQQYDSFSHS RSRINAYRGL ASPAYLSLSN EDPVLAALEL SNELAVLADI
     EKEFKNEYCC LSSQCKDYVV GLLDLCRSTE EVEAIMSGET DTDDTYNLPG RPSLTRLKLA
     IKYELKKFVA HPNCQQQLLS IWYENLPGLR QQTTAVKLLV VMAVAIGLPG LALAYWITPC
     SRVGRIMRSP FMKFVAHASS FTIFLGLLIL NAADRFAGTT LLANMTHRHY HQQAGGPQPD
     PLLLYRMTTT PFTWMEILII SWIIGMIWSE VKEIWSQGLG EYLLEPWNFL DFGMLAIFLA
     SFSCRFSILR HVESAQTFVY THYTTLINVT LPPEILYLTL ARIDWLPSDP QLVSEGLYAV
     AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF LMVFLAFMIG MFNLYSYYLG
     AKQNDAFTTL EESFKTLFWA IFGLSEVRSV VVNNGHKFIE NTGYVLYGVY NVTMVIVLLN
     MLIAMINSSF QEIEDDADVE WKFARAKLWF SYFEEGRTLP VPFNLIPSPK SMLGLATCIR
     AQILRLVRGH SEEKTGTQLN QWFHRCITAF HRVESLTLMS FIFQLGDNSG SYGASNTTSR
     YQKIMKRLIK RYIIKAQADR ESDEITEGEL KEIKQDISSL RYELLEEKAQ NMETLDGLLR
     RMG
//
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