ID H2V437_TAKRU Unreviewed; 522 AA.
AC H2V437;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=SRY-box transcription factor 8 {ECO:0000313|Ensembl:ENSTRUP00000043971.3};
GN Name=LOC101075571 {ECO:0000313|Ensembl:ENSTRUP00000043971.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000043971.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000043971.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000043971.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2V437; -.
DR STRING; 31033.ENSTRUP00000043971; -.
DR Ensembl; ENSTRUT00000044119.3; ENSTRUP00000043971.3; ENSTRUG00000017165.3.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000158046; -.
DR InParanoid; H2V437; -.
DR OMA; LQHKRDY; -.
DR OrthoDB; 2902801at2759; -.
DR Proteomes; UP000005226; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22031; HMG-box_SoxE; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022151; Sox_N.
DR PANTHER; PTHR45803; SOX100B; 1.
DR PANTHER; PTHR45803:SF2; TRANSCRIPTION FACTOR SOX-8; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 152..220
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 152..220
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 68..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..415
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 57536 MW; 5455263CBB47BF9E CRC64;
MRVLKRVPVF SDCSNCAWLR RGALDRDGKF RLRKNEITRI PLFGKTFFQG NPIQICVLPS
KMKEDCHSLT YSPPSPGTKA SMSQSASDSE FPNDKDKSDS AGVITQRSPS SAEDRFPVCI
RDAVSQVLKG YDWSLVAVSA PGERGLKNKP HVKRPMNAFM VWAQAARKKL ADQYPHLHNA
ELSKTLGKLW RLLTETEKRP FIEEADRLRM QHKKTYPDYK YQPRRRKVTK VGEGDCRPGS
TQQQDGLCKT ETTMKLPSAG EVHSYYHQDR AGQSNGPPTP PSTPKTDVLM GTKREVHRPS
DGGSIPPTSR QNIDFSNVDI SDLSTDVIGT IDGFDVHEFD QYLTPNSHGS TALPPSDTGH
GYLNPPGAFI LPNIHSHSIP TWTRKSPALT GMPSCDKPTL SEDTTTRKPL VKTEQMSPDH
HSGSCTSPPP PLQPQCTPGS SVCPSSASSP SSTRPPDYSD LQSSSFFSAI SGYVPPLYQH
PYFHPSCVSY ATPLINSLAL APPSHSPPSG WEQPIYTTLT KP
//
