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Database: UniProt
Entry: H2V496_TAKRU
LinkDB: H2V496_TAKRU
Original site: H2V496_TAKRU 
ID   H2V496_TAKRU            Unreviewed;      2229 AA.
AC   H2V496;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSTRUP00000044030};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044030, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000044030}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000044030}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000044030}.
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DR   Ensembl; ENSTRUT00000044178; ENSTRUP00000044030; ENSTRUG00000017188.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   2229       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003575166.
FT   TRANSMEM     41     62       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    129    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    282    307       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    665    683       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    695    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    786    805       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    862    885       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1205   1223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1243   1264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1276   1295       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1340   1362       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1400   1421       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1441   1465       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1528   1545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1565   1584       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1662   1686       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1698   1716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1746   1767       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    318       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      664    891       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1203   1475       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1528   1778       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1474   1508       {ECO:0000256|SAM:Coils}.
FT   COILED     1768   1791       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2229 AA;  250184 MW;  A9180780CDCBD6B7 CRC64;
     WFERASMLVI LLNCVTLGMF HPCEDINCDS ERCKILQDFD HFIFAFFAIE MVIKMLALGI
     FGKKCYLGDT WNRLDFFIVV AGMLEYSLNL QSVSFSAVRT VRVLRPLRAI NRVPSMRILV
     TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ LWVGRLRNRC FVEDALLFPL TNKYYHTEND
     DENPFICSQP KDNGMRDCNS VPKFFDEGGA QCNLDMYSNI TDNTTCINWN QYYTNCSDSS
     INPFKGAINF DNIFYAWIAI FQVITLEGWV DIMYFVMDAH SFYNFIYFIL LIIIGSFFMI
     NLCLVVIATQ FSETKQRESQ LMKEQRVRFM SNASTLASLS EPGSCYNEIL KYLGYLICKG
     SKQVVHACRF LARRAGINIP ASPPPMEPQR SVRRRRKSSR QGSVSVHHMM HHHHHHHHHH
     HHLGNGSLRG GGSTRGLEGQ DVESIAHNNN RGLAAGTDTG HLTLAPPPVT AAVSVHSVFR
     SESLRCTPSP ITMGSSLGPF ILAPVPMSRV MKRNSVPFAA PGPNTLTNIN FNLNIPNMPR
     ERRLSTLVDT HSPSGQFSCQ LSARDLSNTI STMDTTALTF DPESCPYCAK AISNESEVGT
     EGNDTPGDSD SEGMYEFTQD LRHRDRRDSR QPKKKHLRLG KTAATIVRFW RLVCDTFRKI
     VDSKYFGRGI MIAILINTLS MGIEYHEQPD ELTNALEISN IVFTSLFALE MLLKVLVYGP
     FGYIKNPYNI FDGIIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFMP ALQRQLVVLM
     KTMDNVATFC MLLMLFIFIF SILGMHLFGC RFGSERDGDT LPDRKNFDSL LWAIVTVFQI
     LTQEDWNKVL YNGMASTSPV AALYFIALMT FGNYVLFNLL VAILVEGFQT EEMSKREDLH
     AQLSLIQLPV DTGGGGDASK SGSEINSCAR SMEDVNGSKK DLSASAVPVN GHLDLKTNLT
     PPLITHTAAT PMPVPKLPVG GDPILGYESR RGSNVSAEPA CYDKSPTGAR SSSPHAPWTS
     ASGWTSRRSS WNSVGRAPSL KRQKRQSGER QSLLSGEGGS SSEGEDSMSQ SERVPRHRRM
     ESMETRSSMD LPPDALLQVP YLGHSASMQS SRSPSLRHLG PTERSDCNGK GSASVLVPAQ
     AYLEDNAEDE NAEEDVTVGR FARLFHWLEK KQPEWCRHRN MWSLYLFPPE SRFRVICNQI
     ITHKLFDHIV LVIIFLNCIT IAMERPRIDP TSAERIFLSL SNYIFTAIFV AEMSIKIVAL
     GWCFGDKAYL RSSWNILDGM LVLISVIDIL VSLISNSGTK ILGMLRVLRL LRTLRPLRVI
     SRAPGLKLVV ETLMSSLKPI GNIVVICCAF FIIFGILGVQ LFKGKFFVCQ GEDVKNVTNK
     SDCLLANYKW VRHKYNFDNL GQALMSLFVL ASKDGWVDIM YDGLDAVGVD QQPVMNYNPW
     MLLYFISFLL IVAFFVLNMF VGVVVENFHK CRRHQEAEEA KRREEKRLKR MEKKRRSKEK
     ELAEAQSKPY YSDYSPTRLL IHKMCTSHYL DLFITIVIGL NVIAMSMEHY QQPEELTEAL
     KICNYIFTLI FVLESVFKLV AFGFRRFFKD KWNQLDLVIV LLSIMGITLE KIEEASLPIN
     PTIIRIMRVL RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL
     FGDLICDELH PCEGLGRYAT FRNFGMAFLL LFRVSTGDNW NGIMKDTLRD CAHETTTCYN
     TVVSPIYFVS FVLTAQFVLV NVVIAVLMKH LEESNKEAKE EAEMEAELEL ESRGLEPTPE
     SPLIHDLKRP GCAAYLMTPP PSPPNLHVCA HVSTSISLFP LNKTTKQPTK RQWKPPLEGN
     LLSVKKPTVG RTHSLPNDSY MFLPPQTCDH VSQAQLIAQT KGPQHILGTH SSRSGSRGSV
     HSQPEEFSHQ LTVPTDLFRP ISPHSHSDSE NIPRLQPPRH TQTFSRTLRR QVAVSTDSQE
     ALCTDEGQSI EGFVNMASLS PSLSVDTPSP TCSLSPLPFS HHHQQQQQQP SVCLVPATPG
     ASPKPLRPSS VHTQLHNDAM TEDSGDGSSY TGCQEGQSLC LRELKRFHSV DTQGRSTLLP
     RPRPYSWLDD PRRHSVEVYS MVDSSPQRST ASNSSGFVSQ TISLASPRRK KKMSPPCISV
     DPPDGRMPSP LPSRDTYLRR RVPSSDSKDS FEMGVAEGSG QDGGSPNPST NPKLLTLPSF
     SFEKTSSEH
//
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