ID   H2V4F6_TAKRU            Unreviewed;       592 AA.
AC   H2V4F6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Cullin 4A {ECO:0000313|Ensembl:ENSTRUP00000044090.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044090.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000044090.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000044090.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; H2V4F6; -.
DR   STRING; 31033.ENSTRUP00000064210; -.
DR   Ensembl; ENSTRUT00000044238.3; ENSTRUP00000044090.2; ENSTRUG00000017207.3.
DR   GeneTree; ENSGT00940000156905; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000005226; Chromosome 13.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 3.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          237..465
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   592 AA;  68935 MW;  F25E1C578D6FE888 CRC64;
     ILPRDTGLEL FRIHIVSDSA VQKRAVDGIL EQIELERNGE TIDRSLLRSL LGMLSDLQVY
     RDSFEERFLT ETDRLYAAEG QRLMLERDVP EYLHHVVRRL EEENDRILSY LDQSTQKPLI
     GCVEKQLLGE HMTAILQKGL RNLLDENRVT ELTLLYQLFS KVKGGLPTLL QFWRDYIKAF
     GGEIVCTPEK DKDMVQDLLD FKDKMDNVAQ CCFARNEGFI NTMKEAFETF INKRSNKPAE
     LIAKYVDSKL RAGNKEATEE ELERILDKIM IIFRFIHGKD VFEAFYKKDL AKRLLVGKSA
     SVDAEKSMLS KLKHECGAAF TSKLEGMFKD MELSKDIMIQ FKQYMQNQSD PTNIELTVNI
     LTMGYWPSYT PMEVHLPTEM VKLQEVFKLF YLGKHSGRKL QWQPTLGHAV LKAEFKEGKK
     ELQVSLFQTL VLLMFNEGEE FSVEEIQTAT GIEDGELRRT LQSLACGKAR VLNKNPRGKD
     VEDGDRFNFN NEFKHKLFRI KINQIQMKET VEEQVSTTER VFQDRQYQID AAVVRIMKMR
     KTLSHNLLVS ELYNQLKFPV KPGDLKKRIE SLIDRDYMER DKETPNQYHY VA
//