ID H2V4I9_TAKRU Unreviewed; 814 AA.
AC H2V4I9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=RAS p21 protein activator 3 {ECO:0000313|Ensembl:ENSTRUP00000044123.3};
GN Name=RASA3 {ECO:0000313|Ensembl:ENSTRUP00000044123.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044123.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000044123.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000044123.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2V4I9; -.
DR Ensembl; ENSTRUT00000044271.3; ENSTRUP00000044123.3; ENSTRUG00000017222.3.
DR eggNOG; KOG2059; Eukaryota.
DR GeneTree; ENSGT00940000157953; -.
DR HOGENOM; CLU_008096_1_1_1; -.
DR TreeFam; TF105302; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 5..122
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 133..272
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 339..533
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 576..681
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 814 AA; 92645 MW; E41303657ED30B8B CRC64;
GGVGFHAGSG LSLDRPVMSS SKLTVTAECG AKNIPPYPGP NRMRDCYCTV NLDQEEVFRT
KIVEKSLCPF YGEDFYCEIP RSFRHLSFYI FDRDVFRRDS SIGKVAVKKE DLQKYHGKDT
WFQLQPVSAD SEVQGKVHLE LRLSEVITDS GVINHKLATR VLECQGLPIV NGQCDPYAAV
SLLGPSRSDA KKTKVKRKTN NPQFEEVFYF EVTRPLSYTK RQFDVEEEDV DKLTLRVDLW
NASNLKFGDE FLGGVRVPLR VLGQAGVHDA WYFLQPRENG GKSVKVEELG SLRLNIVYTE
DHVFPSEHYT PLRDLLLHSA DVGPVSASTA HILGEVCREK QEAAIPLVRL FLHYGKIVPF
ISAIAHAEIN RTQDPNTIFR GNSLTSKCID ETMKLAGMHY LQVTLKPIID EICTEHKPCE
IDPIKLKESE NLDTNRENLR HYVDHIFSVI TTSGVRCPTV MCDIFFSLRE SAATRFQVDP
DVRFTAVSSF IFLRFFAPAI LSPNLFHLRP HHPDPATSRT LTLISKTIQT LGSLAKSRSA
NFKESYMAAF YDYFNEKKYA DAVKNVSDAL SLSLIALSFL RFMIKRAQGR NRFGMKNFKK
RWFRLTNHEF TYHKTKGEGN LTGPLCSIPI ENILAVERLE EESFRMKNMF QVIQPERALY
IQANNCVEAR DWIDILTKVS QCNRKRLSTY HPSAYLNGHW LCCKMSADTE PGCTPCTGGL
PANIQLDIDG DRETERIYSL FSAYMTKLIK MQEACGSKSV YDGPEQEEYS SFVIDDPQET
YKTLKLIVSA VQTLEQQHTK YKRDKFKKTK IGSQ
//
