ID H2V5G6_TAKRU Unreviewed; 1645 AA.
AC H2V5G6;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Low-density lipoprotein receptor-related protein 5-like {ECO:0000313|Ensembl:ENSTRUP00000044450.3};
GN Name=LOC101069468 {ECO:0000313|Ensembl:ENSTRUP00000044450.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000044450.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000044450.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000044450.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR STRING; 31033.ENSTRUP00000044450; -.
DR Ensembl; ENSTRUT00000044600.3; ENSTRUP00000044450.3; ENSTRUG00000017350.3.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000156574; -.
DR HOGENOM; CLU_002489_0_0_1; -.
DR InParanoid; H2V5G6; -.
DR OMA; HTPCEDN; -.
DR TreeFam; TF315253; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035676; P:anterior lateral line neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR GO; GO:0032474; P:otolith morphogenesis; IEA:Ensembl.
DR GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0045124; P:regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF16; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 5; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 12.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 13.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1645
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025422286"
FT TRANSMEM 1395..1416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 125..167
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 168..211
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 212..254
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 303..342
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 390..432
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 433..475
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 476..519
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 520..562
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 609..646
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 692..734
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 735..783
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 784..826
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 827..868
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 917..954
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1089..1133
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1134..1176
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1226..1270
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 1487..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1590..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1612..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1645
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1290..1305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1308..1320
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1315..1333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1327..1342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1346..1358
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1353..1371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1365..1380
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1645 AA; 181886 MW; C184F9205B52D4A9 CRC64;
MRGCVCRTRD MGSALLLVQL LVLLPAAHAL PLLLFANRRD VRLVDAEGAR GESAVVVSDL
VDAAAVDFLY TEGIIFWTDV SEEAIKQTYW NLSSNSLTDA LGTGQTVVVS GLASADGLAC
DWLGKKLYWT DSETNRIEVS NLDGTSRKVL FWMDLDQPRA LALNPAQRYM YWTDWGEKPR
IESAGMDGSN RKVLVNQNIY WPNGLTIDLL EHKLYWADAK LSFIHRANLD GSAREAVVEG
ILTHPFALTL SGETLYWTDW QTRSIHACNK QKGDNIREIL SGIFSPMDIQ VLDPSRQPYL
QTPCGDNNGN CSHLCLLSPV EPFYSCACPT GVQLKPDGKT CKPGAEHVLL LARRTDLRKI
SLDLPDFSDI VLMVDDIRHA IAIDYDPVEG FVYWTDDEIK AIRRAHIDGN TSAMLVATEL
KHPDGIAVDW VARNLYWTDT GTDRIEVTRL NGTSRKILIS ENIDEPRAIV LDPVNGYMYW
TDWGQQPKIE RANLDGTDRV VLVDSYLGWP NGLALDYSTG KLYWGDAKTD KIEVIDVDGT
NRQTLLDDNL PHLFGFTLLG DFIYWTDWQM RSIERVHKVT AARETIIDQL PDLMGLKATN
VTETHGTNDC ALNNGGCSHL CFWCQRAVRC ACPMGMELLS DLHTCVVPEA FLLFTNRDSI
RSISLGTHGN DVAIPLTGVK EVSALDFDVS ERRIYWTDIQ AKTITRAYMN GSSVEHVIEY
GLDYPEGMAV DWMGRNIYWA DTGTNRIEVA RLDGRYRQVL VCKDLDNLRS LDNPRSLALD
PASGYMYWTE WGGRPRIARA YMDGKTTTTL VDEVGRANGL TIDYVAHRLY WTDLDTSMIE
STNMQGLQRQ TIVEELSHPF GLTQYQDFIY WTDFNLRSIE RADKRTGLNR TVVLQGQLEL
MLDILVFHSS RQEGGNTCSL NNGNCAHLCL ATPAGAQCCC ASHYTLNSDG QNCSAPTSFL
LFSQKSGISR MVPGDPSPDI ILPIHVLRNV RAVSYDPVDQ LVYWLDGRQN IRRASDDGTT
SSVTVNANSQ SADGQIHDLS LDPYSRHIYW TCETTNTINI QKMSGQHVGV VLKDDANKPR
AIVVSAEKGY MYFTTIQERS AKIEAASLDG TERECLFATG LFRPVALALD TAAGKLFWVD
SDLKRIESSD LTGANRIVLQ DSSILQPAGL TVLGDHLYWI DRQQQIIERV DKLTGDGRTR
IQGRLASLTS IHAAESVARQ HLENHPCFRD NGGCSHICIA KLDGTPRCSC PVHLVLLQDL
LQCGEPPTCS TEQFTCTTGE IDCIPLAWRC DGFTECADSS DEENCPVCSP LQFKCDRGGC
IDAHRRCNGE HDCADQSDER DCQTICPPNQ FRCGDNQCIS KKQQCDTYSD CSDGSDELSC
DADPPGHGAG SGPNAIVSVI AIILLVFVIG GAYFFCQRVV CRCYKGQSGS FPHEYISGTP
HVPLNFIAPS GSQRGTFQGI SCGKSMMSSI SLMGSSSSGA PLYDRNHVTG ASSSSSSSTK
GAFYPQMLNP PPSPATDRSL YNTEVFYSSN SPSSTRSYRA YHPGRGAAPP TTPCSTDVCD
SDYTPHHPPG ALASSGRRWR ASGHGSLGKH KYYVDLNSDS DPYPPPPTPR SQYLSAEESC
PPSPSTERSY FHLCPPPPSP CTDSS
//
