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Database: UniProt
Entry: H2VAE4_TAKRU
LinkDB: H2VAE4_TAKRU
Original site: H2VAE4_TAKRU 
ID   H2VAE4_TAKRU            Unreviewed;      4924 AA.
AC   H2VAE4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000046185};
GN   Name=LOC101061364 {ECO:0000313|Ensembl:ENSTRUP00000046185};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000046185, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000046185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000046185}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000046185}.
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DR   STRING; 31033.ENSTRUP00000046185; -.
DR   Ensembl; ENSTRUT00000046340; ENSTRUP00000046185; ENSTRUG00000018032.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   OMA; RAILSMP; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4242   4264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4467   4487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4532   4551       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4676   4701       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4724   4746       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4805   4828       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      570    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1279   1495       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3975   4001       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3622   3649       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4924 AA;  557322 MW;  4DE665DA8C751BD5 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVATIQK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLANTGQSSE GAGQGGGHRT LLYGHAILLR HSFSDMYLTC
     LKTSRSLTDK LSFDVGLQEH STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSTERYL
     HLSISNGSTQ VDASFMQTLW NIQPTCSSGN MAVGYLIGGH VMRLCHGHDE SLTIPGAESS
     EEMQRIVNYE AGKGASKARS LWRLEPLRIS WSSSHIRWGQ AFRLRHLSTG RYLALSEDRG
     LVLQDREKSD TTATAFCFRP SKEKSDLGAK RDIDGMGVPE IKYGDTVCFI MHVATGLWLS
     YLAPDAKSSR LGPLKRRACL HLEGHMDDGL ILQRCQHEES RAARIIRNTT FLFTNFIRAL
     DRITKGGSTE VAGFVEDVLQ TLNDLIEYFK QPDSELEHEE KQCLLRSLIK RQDLFKEEGM
     LTLLSKCIDR MNLYNSAAHF AEKAGEEAGA AWKDILNLLY ELLAALIRGN RTNCTQFSHK
     LDWLVSKLER LESSSGILEV LHCILVESPE ALNIIQRAHI ESIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRANQNLICD TLLPERDLLL QTRLVNDVQS MRPNIFLGVA DGSAQYKKWY
     FELVIDQVDH FVTGESTHLR VGWANTRGYA PYPGGGEGWG GNGVGDDLYS YSFDGLHLWS
     GRIPRAVASV NQHLLNSDDV VSCCLDLGAP SMSFRINGQP VQGMFEDFNT DGFFFPVVSF
     SAGVKVRFLL GGRHGDFKFL PPAGYSPCYE ALLPKEKMHI EAVKDYKRDH EGVRDLLGTT
     QFLSQSSFIP TPVDTSQVVL PTHLDNVRDK LAENIHELWG MNKIELGWTY GKIRDDNKRQ
     HPCLVDFVKL PETERNYNLQ MSSETLKTLL ALGCHVAQVN IHAEDDLKKI KLPKDYMMSN
     GYKPAPLDLS DVKLTGGQEV LVDKLAENAH NVWAKDRIKQ GWTYGIQQDV KSRRNPRLVP
     YALLDERTKK SNRDSLREAI RTLVGYGYDI DPPDQEGAHV VVDETIETTR LFRVEQTYAV
     KTGKWYFEFE AITGGDMRVG WARPGCRPDV ELGADDQVFV FDGYRGRRMH AGSRYFGHPW
     KKGDVVGCMI NMEDKSMIFT LNGELLITNK GSELCFTDFE TEEGFIPVCS LGMSQIGRMN
     LGKDASTFKY YTMCGLQEGF EPFAVNMKRE ITMWFSKRLP TFVNIQQDHA HIEVTRIDGT
     VDSPPCLKVT HKTFGTQNSN SDMLYCRLSV PVEFYSADTL LDESLRFSLF RVQMSSCTAF
     VFTVTLPTTT EALTTRDFKN TGVRKCGCAT VCFISSQYYH SVRVFAGQDP ASVWVGWVTP
     DYHYYSKNFN LGKTRTVTVT LGDERGRVHE SVQRSNCYMV CAGDAVSPSS SSRSTSDLEI
     GCLIDLVTGL VTFTANGKEL STVYQVEPNT KLFPAVFVRP TSADLFQFEF VKMKDAMPLS
     SAIFKSEHRN PVPQCPPRLD VQTIVSVLWS RMPNTFLNVE TARVSERHGW VVQCLEPLQI
     MAVHIPEENR CLDILELSEH EDLRKFHYHT LMLYCALCAL GNTRVAHALC SHLDQSQLLY
     TIDNQYLSGM LREGFYSVLI SIHLETAKEA RLMMNNEFII PVTDETRSIK LFPDESKRHS
     LPGVDLSTSL KPRVNFSPVG VINRGRHQYL HSPQIPLGIL KEKAISMLTE AVQGGGTHIR
     DPVGGSVKYQ FVPILKLIGT LLIMGVLTSE EVRVILLMID PNVFGEVQEG EEARGEEAGP
     AAEKEEVSKN EEKAVEAGEE ESKESKPSAT KGLLEKLLPE PVKRQMCELL QYFCDCELKH
     RIESIVSFSD TFVSKLQFNQ KFRYNELMVA LNMSAAVTAK KTKEFRSPPQ EQINILLNFS
     AGDDCPCPEE IQEELNSFHE ELRLHCGIPI EEEEEDQDTS IKGRLLALLY KIKGPPQKAE
     KEPEKEQAAP TNLKELISQT ITCWAQESHI QDPELVRVMF SLLRRQYDGI GELLRGMKKT
     YTISAASVQD AINLLASLGQ IRSLLSVRMG KEEEKLMIDG LGDIMNNKVF YQHPNLMRVL
     GMHETVMEVM VNVLGGDKSQ EIAFPKMVAS CCRFLCYFCR ISRQNQKAMF DHLSYLLENS
     SVGLAMRGST PLDVAASSVM DNNGLALALE EPDLEKVVTY LAGCGLQSCA MLLAKGYPDL
     GWNPIEGERY LSFLRFAVFC NGESVEENAN VVVKLLIRRP ECFPALRGEG GQGLLVAMKE
     AIKISEDPSL DLPKIPDGDQ NKPLPGPGEE GGEIIHMGNA IMSFYSALID LLGRCAPEMH
     LINAGKGEAL RIRAILRSLV PTLDLVGIIS IPPKMPMVNK DGSVTEPDMS ACFCPDHKAP
     MVLFLERVYG IQDQTFLMHM LEVGFLPDLR ASASLDTEAL STTETALALN RYIGSAVLPL
     LTRCAALFAG TEHYTQLIDS TLQTIYRLCK GRSLTKAQRD AIEECLLAIC KHLRPTMMQQ
     LLRRLVFDVP VLSEYCKIPL RLLTNHYEQN WKYYCLPAGM GSFGTASDEE LLLTKKLFWG
     TFDSLSHKKY DPELFKMATA CLCAIAGALP PDFVDASLGA TLEKQASLDS QGNFDPKPIN
     TANISLPEKL EYITNKYAEH SHDKWSSEKV SAGWKHGESL DEHTKSHPLL KPYKALTEKE
     RETYRWPVRE SLKSMLAMGW NIERSKEGEP MFQREGDTHK KTSDPQINGF SPAPMDLHNI
     TLSRELQSMV EMVAENYHNI WAKKKKTELI SKGGGTHPLL VPYDTLTAKE KYRDREKAQE
     LFKFLQISGY IVSRGLKDIE QDSSSMEKRF SYKFLKRLLQ YVDSAQEFIA HLEAMATSGK
     TDKSPHDQEI KFFAKVLLPL TDQTFKNHCL YFLSTPSKNL SSCGCASNKE KEMVTSLFCK
     LAALVRHRIS LFGSDSTIMV SCLDILTHSL DTRTVMKSGS ELVKAGFRTF FENAAEDLEK
     LVEMLKLGKF MQSRAQMKSV SQSINYVTVA LLPILTALFD HIKTHEFGID LLLNDVQLSC
     YRILTFFYSL GTGKNIFVER HLPALGESLA TLVGAMPVAF LEPDLNAYNP LSVFNTKTPR
     ERAILSMPDT VEEMCPEIPR LDKLLKDVND VSESGARYSD MPQVIEVILP MLCNYLSYWW
     EKGPENSPPD AQCCTMVTSE HLSVILGNIL RILNSNLGID DAPWMKRIAV YSQPIICKAG
     AGLLRSHFLP TLVKLKKKTE KVVAEEELLK ADSKGDNQEA ELLILDEFAV LCRDLYAFYP
     MLIRYVDNNR SRWLKEPDAD STELFRMVAE IFILWCKSHN FKREEQNFVV QNEINNLGFL
     TGEAKTKMSK KSSISNSGGD QERKHKRRRG EYYSIPTSLI VAALKKMLPI GLNMCTPGDQ
     ELISVAKKRY SLKDTDDEVK EHLRQNLHLQ DKSDDPAVQW QLNLYRDVVV KCEEPVNPEH
     TVSRVQSISA ALFHLDLVEQ PLRNKKCVWQ KLLSKQRKRA VVACFRMAPL YNLPRHRAIN
     FFIPAYQRLW IEAEEYSFEE KLVQDLAKTP MKIVEEEEEE VAEIQPDPLH QLILHFSHNA
     LTERSHLEED PLYIAYADMM AKSCAEDEEE EEEEEKEKTF EEKEMEKQKI LYQQARLHAR
     GAAEMVLQMI SATKEGRLGP MVTCTLKLGI SILNGGNVQV QQKMLDYLKE KRDAGFFKSL
     SGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSSELFFKGS KVLQNDEFTK DLFRFLQLLC
     EGHNGDFQNF LRTQTGNTTT VNIIISTVDY LLRLQESISD FYWYYSGKDV IDDTGKLNFS
     KALSVAKQIF NSLTEYIQGP CIGNQQSLAH SRLWDAVVGF LHVFANMQMK LSQVQSLQRW
     LDGHDASQIE LLKELMDLQK DMVVMLLSLL EGNVVNGTIG KQMVDTLESS NNVEMILKFF
     DMFLKLKDLT TSDNFREYDP ECKGIISKKE FQKSMESQKQ YSQSEIEFLL SCAEADENDM
     FNYKEFVERF HEPAKDIGFN VVVLLTNLSE HMPHDSRLAT FLDLAESVLS YFEPYLGRIE
     IMGSAKRIER VYFEISESSR EQWEKPQVKE SKRQFIFDVV NEGGESEKME MFVNFCEDTI
     FEMQLASKIS EPDVGEQPEE EEDDGHSILG DLVGEEDDAL ESASAFSAAC RSVKRRISKV
     RHLFSIKNVR KQFKKIKKLS IKEIITGFFS FFWMLFTGFF RGIYSIIFGF FHIIWASMFG
     GGLVEGAKNM KVTDILGNMP DPTQFGIHGD VIEGEKVEAL ESSGSLDITM TPAGDTAEVD
     VMLELLTSPK KEGGKHMEPG LGDMSELSSE TAATDQKKVR KQSRLFGKPV FPSLTSFHPS
     GGQKAMKTEE TPESEPEKAD FSNGSTENRE KEDKPTEKET KETVTEEKPK ARSSRQKDEA
     PAFTSSVFAL LDVYLTKLLN YLARNFYNLR FLALFVCFAI NFILLFYKVA GDDTDDENRW
     GGDAEDDEDT FFDMDEFVLQ ESTGYMLPTL RFLAVFHTII SLLCLVGYYC LKVPVVVFKR
     EKEIARQIEF DGLYITEQPS DDDIKGQWDR LVINTPSFPN NYWDKFIKRK VINKYGDLYG
     AERIAELLGL DKSALDFDPT VETVEKEASL VSWLLSSIDT KYHTWKLGVV LTDNNFLYLI
     WYTTMSIFGH FNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV
     VAFNFFRKFY NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDELED PAGDPYELYR
     ILFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI GNDYFDRTPH
     GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM YQERCWDFFP TGDCFRKQYE
     DQLG
//
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