ID H2VCM1_TAKRU Unreviewed; 1154 AA.
AC H2VCM1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Glutamate metabotropic receptor 1 {ECO:0000313|Ensembl:ENSTRUP00000046964.3};
GN Name=GRM1 {ECO:0000313|Ensembl:ENSTRUP00000046964.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000046964.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000046964.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000046964.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2VCM1; -.
DR STRING; 31033.ENSTRUP00000059879; -.
DR Ensembl; ENSTRUT00000047123.3; ENSTRUP00000046964.3; ENSTRUG00000018354.3.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234595; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000005226; Chromosome 16.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:UniProt.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR CDD; cd15449; 7tmC_mGluR1; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001256; GPCR_3_mGluR1.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR019588; Metabotropic_Glu_rcpt_Homer-bd.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF29; METABOTROPIC GLUTAMATE RECEPTOR 1; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF10606; GluR_Homer-bdg; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01051; MTABOTROPC1R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SMART; SM01229; GluR_Homer-bdg; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1154
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025409582"
FT TRANSMEM 598..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..835
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..858
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 884..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..902
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 128379 MW; A3A6CAF92C5232AB CRC64;
MGLVALLCVP TLFFRILVLS RSSSISERST VPRAAPRAVA RMDGDVIIGA LFSVHHQPSA
EKVAERKCGD VREQYGIQRV EAMFHTLDRI NADPDLLPNI SLGCEIRDSC WHSSVALEQS
IEFIRDSLIS IRDDKDGAKW CIDGTPSHHP PPSKKPIAGV IGPGSSSVAI QVQNLLQLFN
IPQIAYSATS IDLSDKALFK YFLRVVPSDT LQARAMLDIV KRYNWTYVSA VHTEGNYGES
GMEAFKELAS QEGLCIANSD KIYSNAGEKH FDRLLRKLRE RLPKARVVVC FCEGMTVRGL
LMAMRRLGVF GEFLLVGSDG WADRYEVVEG YEQEAEGGIT MKLQSAMVKS FDDYYLKLRL
DANARNPWFP EFWQYRFQCR LPGHPQENKN YKKVCSGNES LQENYVQDSK MGFVINAIYA
MAHGLHDMHE ELCPGQTGLC DAMDPIDGSK LLDYLLKTSF RGVSGEEIYF DENGDTPGRY
DIMNLQSVGD TGEGRYDYIN VGSWHEGILA MDDSKLWLNS SDMVRSVCSE PCSKGQIKVI
RKGEVSCCWI CTTCKDNEYV QDEFTCKACE LGWWPDDLLA GCEPLPLKYL DWADVESIVA
VAFSCVGILI TSFVTFVFIQ YRDTPVVKSS SRELCYIILA GIFLGYICPF TLIARPTVVS
CYLQRLLVGL SSAMCYSALV TKTNRIARIL AGSKKKICTR KPRFMSAWAQ VIIAFMLISV
QLTLEITLII LEPPEPIKSY PSIREVYLIC NTSNVGMVAP LGYNGLLIMS CTYYAFKTRN
VPANFNEAKY IAFTMYTTCI IWLAFVPIYF GSNYKIITTS FSVSLSVTVA LGCMFTPKMY
IMIAKPERNV RSAFTTSDVV RMHVGDGKSA AQCGSNSFLN MFRRKKPGSG NTNSNGKSVS
WSESGPRHPP RGGNVWHRLS VHVRKQEAGL NQMAVIRPLT NTPDPHSCEP STCDLGTDPL
PPRETRGAKP LLEEDDLSDS QCPLQPPPHA RQRHVLESDE EKPASYSPLK GYAPERSRGT
VVDTHSSHAP TLSDHTAKEV MPANQHLTLT PSQPPLTQKM GSFEERVSED EELDLLHSYI
YDAKGDDDDD DFNQTKAKLG DSLVLSPPSP FRDSVCSGES ASGSPVMEPM LGKAPSSFYT
SDIYGDYAHS SSTL
//