ID H2VCX5_TAKRU Unreviewed; 247 AA.
AC H2VCX5;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA methyltransferase {ECO:0000256|RuleBase:RU367087};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU367087};
GN Name=BCDIN3D {ECO:0000313|Ensembl:ENSTRUP00000047068.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000047068.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000047068.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000047068.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-phospho)-ribonucleoside-RNA + 2 S-adenosyl-L-
CC methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-
CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:58640, Rhea:RHEA-COMP:15179,
CC Rhea:RHEA-COMP:15182, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:138282, ChEBI:CHEBI:142777;
CC Evidence={ECO:0000256|ARBA:ARBA00036615};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-phospho)-ribonucleoside-RNA + S-adenosyl-L-
CC methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-
CC adenosyl-L-homocysteine; Xref=Rhea:RHEA:58656, Rhea:RHEA-COMP:15179,
CC Rhea:RHEA-COMP:15181, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:138282, ChEBI:CHEBI:142776;
CC Evidence={ECO:0000256|ARBA:ARBA00036772};
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361, ECO:0000256|RuleBase:RU367087}.
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DR RefSeq; XP_011611992.1; XM_011613690.1.
DR AlphaFoldDB; H2VCX5; -.
DR STRING; 31033.ENSTRUP00000047068; -.
DR Ensembl; ENSTRUT00000047227.3; ENSTRUP00000047068.2; ENSTRUG00000018395.3.
DR GeneID; 105417806; -.
DR KEGG; tru:105417806; -.
DR CTD; 144233; -.
DR eggNOG; KOG2899; Eukaryota.
DR GeneTree; ENSGT00940000153993; -.
DR HOGENOM; CLU_082749_0_0_1; -.
DR InParanoid; H2VCX5; -.
DR OMA; RKICFYR; -.
DR OrthoDB; 1130801at2759; -.
DR Proteomes; UP000005226; Chromosome 19.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR039772; Bin3-like.
DR InterPro; IPR010675; Bin3_C.
DR InterPro; IPR024160; BIN3_SAM-bd_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12315; BICOID-INTERACTING PROTEIN RELATED; 1.
DR PANTHER; PTHR12315:SF1; RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE; 1.
DR Pfam; PF06859; Bin3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51515; BIN3_SAM; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU367087};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU00848};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367087}.
FT DOMAIN 35..247
FT /note="Bin3-type SAM"
FT /evidence="ECO:0000259|PROSITE:PS51515"
SQ SEQUENCE 247 AA; 28221 MW; 0B6DE9DF72DA57D2 CRC64;
MATCSPNTDR TDEINDPGAA PFGNFINYYT FNPPENRLNL IPATLLRDLD YNGDTTLILD
VGCNSGELST AFYKHLVPDC EEQSDDSKVY LLGFDLDEIL IQRAQQTNSL PSSISFITMD
IIKDTEQLQH YLDQHGCSSF HLCLCLAVTM WIHLNHGDSG LLQLLSRLAT FSQHLLLEAQ
PWKCYRSAAR RLRKLGRSDF DHFKTLNIRG DIAEHAREHL ENHCGMELIQ SFGSTSWDRK
LLLFKRR
//
