GenomeNet

Database: UniProt
Entry: H2XSF3_CIOIN
LinkDB: H2XSF3_CIOIN
Original site: H2XSF3_CIOIN 
ID   H2XSF3_CIOIN            Unreviewed;      5075 AA.
AC   H2XSF3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   07-JUN-2017, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCINP00000032587};
OS   Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000032587, ECO:0000313|Proteomes:UP000008144};
RN   [1] {ECO:0000313|Ensembl:ENSCINP00000032587}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15114417; DOI=10.1007/s00239-003-2559-6;
RA   Gissi C., Iannelli F., Pesole G.;
RT   "Complete mtDNA of Ciona intestinalis reveals extensive gene
RT   rearrangement and the presence of an atp8 and an extra trnM gene in
RT   ascidians.";
RL   J. Mol. Evol. 58:376-389(2004).
RN   [2] {ECO:0000313|Ensembl:ENSCINP00000032587}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCINP00000032587}.
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DR   EMBL; EAAA01000706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EAAA01000707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EAAA01000708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7719.ENSCINP00000032587; -.
DR   Ensembl; ENSCINT00000035893; ENSCINP00000032587; ENSCING00000021152.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2XSF3; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000008144; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008144};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4387   4405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4603   4621       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4685   4704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4830   4854       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4875   4897       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4951   4974       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       92    147       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      154    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      208    263       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      269    327       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      334    391       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      583    799       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1029   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1380   1598       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   5075 AA;  577003 MW;  FD7FE9D3AC76BB61 CRC64;
     MAESCDNDEE VHFLRTDDAI YLQCVRQKDQ GKVCLAAEGF GNRLCYVEPS QDTDAEPTDA
     PRCVFVLSQA LSVRALQELL ASEEAEGGAT HSRTLLYGNA IQLKHELSGM FLTCLTTASS
     ANDQLAFDVG LGEEETGETS WWTVHPTSKQ RSEGEKVRIG DDLILISISS ERYLHLSCGD
     GDDSSVQASF QQSMWTVGPV ASGGSKAQGY LTGGDAIRLF HGHMDDCLTM HTMDENKSHS
     RSIIYESGSA GSHARSLWRL ELMQIKWFGS HVSWGCPFRL RHITSGLYLC MLDDRSLMLM
     GPENASYRMS AFCWQSSKDK AEPLTEHEID GMGVPVIKYG DSVCYLQHVE TGLWVSYQVV
     DTKSVRVGPK QRKAVLHHEG HMDDGLALSR AQSGESRTAT IIRRTAQIFL SFISALDSHQ
     PKKLGRRPDH PNVAEMEQCV NDLIDYFIEQ EDKADDGSTD EHEVRQIRKQ ELKNRQDLFQ
     EEGAISRILQ CIDKLGAYGD TGNFAQIVGS EAAASYEFLL NSMYVLLAAT VRGNRDNCAK
     FARHLDWLIS QFDGQQASMG ILEVLSAVLS DSQEALNMIK PDHIKSIISL LEKHGRNAKV
     LEVLCSLCVC NGVAVRSNQN LICETLLPGR DLLLQTTVLG YITNVQPNIF MGVSASCAQY
     KKWYYELLVE KIDPVCSSSG PHLRVGWGNT VGFSPYPVGG DYFGEAGVGD DIYSYGYDGL
     NLWTSHRACS VGSNNRHLLA ANDIVSCCMD LSIPSISFRI NGQPVQGMFE DFNLNGLFFP
     VVSFSAGIKV RFLFGGPHGE FKFLPPVGYA PTYEALLPGR RLFLSPCKSY GNLSRGYIMG
     PGSSWEHTVF VPNAVNTQNV ILSHFLQAVV PKLAESIHEL WAMTRIQGGW SYGTVRDEAK
     KQNPCLVEFA RLPAQERSFN LTMSYETLRT IIALGYHVGI ADEEAEYNLR KLKLPQSYIM
     ASGYKPSPID LSHIKLTQQM EDLVEKLANN AHNVWARERV KQGWTYVNLK DVGKKRNPRL
     VPFSLLDELA KQSNRNSIRE LIRTLIGHGY MIEPPDDRLK DKDTKKKNQV QCNKMRIFRA
     ERTHAVQSDK WYFEFTVESK GEIRVGWATP DCLASTDLGA DAKAFVFDGH NALKWNNGAE
     SFGRRWNAGD VVGCLLDFNE GVISFTLNGE LLIDGHGQET AFENLSSDIS LVPVVSLAVD
     QRGFLNFGRD SGTFKFYSSI GQQEGFQPFA FGMRSPIAMW FTKNLPSFCN IDETDQNIEV
     KRLPANNHRP PRLKVIHKQI GGTGSHDFTP DWFYTRLNLP ITMATVFTKR LTLCLFLFSP
     GHIINLFNES ESVMEEDIDN DFEVLRKTAR GGLSPPLPAV DLKNERHHHH HHGNSNTLPI
     PVYHVKQLCD NELKIYTYKF LKNMFHFSKP KSSMVQGNNG VNNTAKSRLT EEVLPDQYAD
     VLYKNDIDQL LQSTQYSFSV RIFPEQDPGS VFVGWVTSDF HWNAEKFQQE FIPTVTITLG
     DDKGKVSESV KRSNCFVLWG GDLHQQTSAT PPPANQSSPG ILVTCIIDIS TGLLTFTANG
     KNLNTFYQVE PNVRLYPAVF SFPTTHSVFQ FELGRSKNCM PLSAAVLECE RKNVIPQCPP
     RLVVQSLRKV TWTRMPSKLP HPECRRESVR SKGWTSELKP SNTDASILHV PEENRCIDLL
     ELTENEELLH FHEQTLKLYR SMCALGNHRV SHALCSYVDQ KQLMHVVRNN DLIGSIRATY
     HNLLIEMHLA PHANARKNTQ HEYMFPLNEM TRSIGLFANP ETKDPTLPGV GSTSSLRPSM
     HWSQVNFVMH NPSLIHERPL HVPEFPLDEL CYNVILQLQD AVVCCYKNCK DIMGKNQQYV
     LVPLIRLTTT LLEMGVFVDE DVKKILILLD PNFFGSFMKD MDGVEDKRVI QKYIKNNKLS
     NRKQYVDERV YKIIKNAHSG LLCLDLVESV KLVLCDLLEH LMNLVLRHRV EALVSFSCLV
     VDHLQQNQRN RYQRVMESVN MSAAMTAKMT REFRSPPMDQ MAILLKFKNE ELEEECPLPP
     SIKDLIWNFH MDMLIHCGET IEDVETNETE IPLRSRLVAF ISHILNRKND KADETGEEQI
     EVITSLRDLI TSTMVRWAQG SRLNNPQLVR SIFQLLYRQF NGVGEAIQCI NKTYCISEIS
     EVDTMGLLDS LSRLRSLLSV KLGEEEETLI IKELNTIMNN KVFYQHPNLM RVLCMHETVM
     EVMVSVLGGE DDETNSNEVQ FPRMVAACCR FLCYFCRISR LNQGALFEHL GFLLEHSAVG
     LASPSMRGST PLDVAAASVM DNNELALALK ESDLAKIVEQ LGTCGVESCQ LLLRKGYPDI
     GWNPVEGERY LDFLKNAVFV NGESVEENAN LVVRQLIRRT ECLGPSLRGE GGHGLLSAIT
     SALQICRDRS KDGPDKQVTF KFNTFRNDFD DENDIHMGFS ILAFYSTLID LLGRCAPEQC
     LIMQGKSDAI RIRSILRSLV PLEDLIGVIS LPFELPRLER DGSTNVREPD LSACFIPDHK
     ASMVLFLERV YGVDDPKLML RLLEVGMLPD MKAAAQLDTP LLHTTDMALS LNRYMCYSLL
     PMLVKHVELL EQWQHRVVLI DQLLHTIYRM SQAQALTKAQ KEMISNCLVA VAGVLRPSLL
     QGLLRKLTFD VPALTEETYV PIRLLTQHYA RCWKYYYLHD GCSEFGRATD EEKHITMVLF
     WGIFDSLAKK PYQQELFSKV LPCLCSIANA LPADYALSPA LEQLKEPSIT AHGKFVPRPV
     DTKCIMLPEK LDTFVNKYSE QWHDTWALER FTAGWTYDSH YNDHFKHHPM LKPYRLLNDR
     EKDVYRPTVR EGIKTLLAWG WTIRKARDAT EQLPAKVRCS SQSNISASEA HGYLPRPYDL
     SGVILSREMM RTAEMLAENF HLVWAKKKFN EMEAKMAANS SQPSSPTMTT NPMLVPYDRL
     TAKEKEKDRS KSYDLLKFFQ FNSYMLTKDE KEELDIKSSV EKRFSSMMLV RLLNYVEKST
     VYVNGMIQAA ETVKQRRQEH AAFGDHDIKF FAKVGMPFIE SYFKTQEIYY VTVSGSLNEG
     MSVASNKEKE AVTLLFCKMA LLIRQRTAMF GVDASVAINC IKVLAECIDA STITKSCPEH
     IKQALITFFN NAAEDLKKML NHIRSGRMKH LRKMMLGAQT TNYVTHCILP VLTILFRHLG
     RHNFGKDLLL DEIQVSCYKI LNGLYSLGTG KGAFIDRHRS QVGECLAAFA SAFPVPFLEP
     RLNKFNSCSI YNILSIKDRK LLGLPPKLEQ LTPLLPTLNN LLSDISHLAE SGAKYEEAPE
     MIDIILPMIC RYLPMWWKQG ACVAQQTNDK RIPIEESSGC GTAVSGEILN NILRDVLRLI
     QNNLGSDEAD WMKRIAVYAQ PILVQSDPDL LTSHFLPILN KSLKRIQQIR DLEEQVKYEQ
     RVNDVSDLEL LMLEDYGIIA RDLYAFYPLL VRYIDLSKSL WIREKNQNAI ALFKLLSEIL
     VIWAKSVNFR REEQNFVVQH EIDNMSVLTA DKSATPNAAS ALVSILNFMG KKANRRIVKK
     RGDRYSPSTS LIVACVKRML PVALNMGKVG DCNLLQEAKT RFLKKEMEDD VKEYLISALR
     ENFYNTQISI CRKVNEDLTN EHGDITTRAD WLLEISRVQY HLHLTEHPPK SRRAVWKKLM
     SKQRKRAVVS CFRMVPLYNL PIHKVISMFV PSYSQHWVYT DQSNFAGKLI NLVHKVFKNQ
     PNQEEGKTLH CDPLSQLIQV FSMSAVTSVV NSENDDLYLA YSELMTQSCH TGDDEEEDEG
     EESEKSFEEK EKEKQRLLYE QKRLATRGVA EMVLYMISAS GGDVSDTIVT TLQLGIALLT
     GGNVLVQKIM LDHLKAKKDV RFFTSVAGLM DQCSVLDLNA YERSLKSESL GHVNECTITD
     LSLPGEKTMS DAELTCALFR FLQLLCEGHN AGKLDFQNYL RTQVGNNTTV NIIISTVDYL
     LRLQEAISDF YWYYSAKETI DAPGQENFSK AIAVAKQVFN TLTEYIQGPC EGNQQALAHS
     RLWDAVVGFL HVFANMQMKL SQDSKRQLSL LKELLDLQQD MIVMLLSMLE GNVVDGTIGR
     QLVDTLIESS HNVELILRFF NMFLRLKDIT SSDKFLEYDA EHTGFVSRKD FQRAMEASKI
     YSSEEIDFLL ACAVSTDDKL NYDEFTEQFH EPAADIGFNM AVLLTNLAEH MPRDTRLKKF
     LEMAEAMLEY FQPNLGRIEI IGSAKRIERV YFNIKPSSLD QWHKPQVQES KRQFFFDVIN
     DEGDNGRMEE FVNFCEDTIF EMQLASEISE AGFGASSSSA VNDEEGDDKD EEDAAAKQKT
     VYNTEHNIYL HFLSNRSGEI LPSFNFKVVK SYVRQFRAMT WIEVITSLVF LFFTFNIKLC
     KLSIELLQIF GNFLYVLFFS NFLVVEVKKK SLTEIIDEMP CPTHERIQHS VENLSDSGTD
     DTGQDQTKGD KEDFISDVFG MDIKKSKELI KAVVHTKPEA GFGDFTVDEA ADTFSLIASD
     YESGINTPRT SKIKKRIYGN LSSLENSSTS EQRLSNLKSA MSFDERSGED NISPWYTCMK
     ECGRPARYKH EEKTEDRNAM YLDTWNAFCM GTMGLFARNF YKFKILALGL TFCINFILLF
     YKVSTSCDIQ SSGVYTMACN QNLIPQQWHS INNDLKVDSE SSEDEVEESL ILEDTSKYME
     PTLRAFSIIH FILSFSMLVS YYGLKVPLVI FKREKEVARK LEFDGLYVNE DPTDDDLSGR
     WDKLVISCPS FPSNYWDKFI KKKVLDKFGE QCGQDRIQDL LGMDHSNTSF LDEEEPPKGN
     ILTQLFLNVD IKYTVWKTGV IFSDQSFLYL LWYFVMSIFG QYNRFFFSLH LLDIAMCSKG
     LRTILTSVTH NGKQLVLTIG LLTVVVYLYT VIAFNFFKKF YNKGEGDDED WKCNNMFTCF
     QFHFYSGVRA GGGIGDELED PSGDAWEFYR IAFDISFFFF VVVILLAIIQ GLIIDAFGEL
     RDQQEQVKED MDTKCFICTI GIDYFDQVPH GFETHTLQEH NLANYMFFLM HLINKDETEH
     TGQETYVWQQ YQERCWEFFP VGDCFRKQYE NELSG
//
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