ID H2XXL7_CIOIN Unreviewed; 561 AA.
AC H2XXL7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Nucleolar protein 56 {ECO:0000256|ARBA:ARBA00040742};
DE AltName: Full=Nucleolar protein 5A {ECO:0000256|ARBA:ARBA00041388};
GN Name=LOC100178209 {ECO:0000313|Ensembl:ENSCINP00000034401.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000034401.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000034401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC {ECO:0000256|ARBA:ARBA00009211}.
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DR AlphaFoldDB; H2XXL7; -.
DR STRING; 7719.ENSCINP00000034401; -.
DR Ensembl; ENSCINT00000034015.1; ENSCINP00000034401.1; ENSCING00000019946.1.
DR GeneTree; ENSGT00940000153534; -.
DR HOGENOM; CLU_015495_4_0_1; -.
DR InParanoid; H2XXL7; -.
DR OMA; DNYMFAK; -.
DR TreeFam; TF105713; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0031428; C:box C/D RNP complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0021556; P:central nervous system formation; IEA:Ensembl.
DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:1905812; P:regulation of motor neuron axon guidance; IEA:Ensembl.
DR GO; GO:1904396; P:regulation of neuromuscular junction development; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR GO; GO:0001966; P:thigmotaxis; IEA:Ensembl.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP58/56_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR PANTHER; PTHR10894:SF0; NUCLEOLAR PROTEIN 56; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 294..412
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 445..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 62774 MW; 5580DB2FD41382F5 CRC64;
MAPQLYVLYE HAAGYALFFV KEVEDIGSLL PTVEKAVLDF TLFASTVKLV SFLPFKSGTN
ALDNVNAVSE GIVHEDLKVF LSSNIPKLQK GEVLLGINDT RISGTIQEET GIRCTTSDAV
TEILRGLRLH FPNMVKGLTM QGEAKAQLGL GHSYSRAKVK FNVNRSDNMI IQSIALLDQL
DKDINTFSMR VKEWYSYHFP ELVKISSDNF MYCRLVKAIG NRKAMAENIE EQLEEITMDS
AKAQGIISAS KMSMGMDVSP IDLINIESFC SRVISLTNYK KGLVEYLHKR MQSVAPNLST
LIGDVVGARL ISHAGSLTNL AKYPASTVQI LGAEKALFRA LKQKGNTPKY GLIFHSTFIG
RAGAKNKGRI SRYLANKCSI ASRIDCFTEH PNSVFGEKLK DQVEERLKFY ESGEAPRKNC
EVMKEAVIES EALIKAEVEA VAEEAKKTKS KKKKRKSEPV DLTEEPEAKK VLTENNQKSA
KKKKAKKQPV DDEDVKEVEP EQMEVDTPKK KKKKKQKEEE AATEEENEPK SAKKKKKKTK
EIDAVENTEV ELVLKKKKKK K
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