ID H2Y2U9_CIOIN Unreviewed; 884 AA.
AC H2Y2U9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=VPS9 domain-containing protein {ECO:0000259|PROSITE:PS51205};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000036234.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000036234.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; EAAA01000692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H2Y2U9; -.
DR STRING; 7719.ENSCINP00000036234; -.
DR Ensembl; ENSCINT00000031508.1; ENSCINP00000036234.1; ENSCING00000021730.1.
DR GeneTree; ENSGT00940000157021; -.
DR HOGENOM; CLU_010760_0_1_1; -.
DR InParanoid; H2Y2U9; -.
DR OMA; LCHPLCT; -.
DR TreeFam; TF351261; -.
DR Proteomes; UP000008144; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030133; C:transport vesicle; IBA:GO_Central.
DR GO; GO:0097422; C:tubular endosome; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0045022; P:early endosome to late endosome transport; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR CDD; cd22885; ANKRD27_zf1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR24170; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27; 1.
DR PANTHER; PTHR24170:SF2; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF02204; VPS9; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 6.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS51205; VPS9; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 244..382
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT REPEAT 462..494
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 495..527
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 566..598
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 741..773
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 775..807
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 808..840
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 841..873
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 884 AA; 99959 MW; 8AC30D96619F9876 CRC64;
MSAYDEDLTE NGWYLALSQK HEDLFIRATN ERWMICIPRV GSWKGGIEDG DLFSQKSFES
HILKQLVVYG DKPEVESNKY LTYNGKEVFI TGPTVTCGEG FTNNFNIPIL FEETFFNQHD
ESYVVLCLSQ PLEQHLVSVG GNFFSPTDEE SSSSEVEKAS GPRWESYGSY VWTRAYHGKR
LHHFIDECAE KFITSMVQNV IKDSKLKKYI EVPSQQTALY SSLESYILHG TYVVNMRELN
DIMSVQDEQL NKITRNLSSV KYDDLEIKEE LCTGIPRARR ELSMMNRFRT PGEKLECLEN
TIRFLSPRTS QATQPIVMSS DDLLPILIYL VLKCEITNWL ANLMYMKYFY FTKTNKDQHS
FYLATLEAAV EHVRNRNIKI DRTKIAGNVP RLFTWSDKLT ILLIENVDVA GVDRLLRQAQ
DMKSLHDHDK CHPLCECNNC TKLSNRKANR GSYVSVSSRD DRGRTALHIA AVTGKHEVVD
TLLNHGSDIN ASDYHGATPL HLAAQEGSQS VIFLLLHHEA AANAVDNNNN TPLHLACYGG
HDGSVKAMLF YDPVRAVVKV DAVNDQGDIP LHIASRWGYA SIAQALVECG SDISCQNRKK
ESPLDVAHNS QMKYILQHTE LTVTYSNLRP EHTVPVVNKT KHSNINQLTQ KINQSNALKP
KSSNLIGQFK REKPSLPKQI LKLHRAVTDN DVHMVAYMCG WGLDDDRSCD PLCQCYKCQP
SQVVLSYMYD IILHANSTSP DGSTPLLISC MRGYVEMTRM LLDHDARVGC KSKDRELSPL
HLACQYGYEE IVRLLLDHGA VCDVRNAEGN TPIYMCAANG HASCAEVLLE FGASVNIRNH
KYDAPLHEAV KWRNINVATL LMESGAMTYY KNKQGITPLQ MAKE
//