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Database: UniProt
Entry: H2Y875_CIOSA
LinkDB: H2Y875_CIOSA
Original site: H2Y875_CIOSA 
ID   H2Y875_CIOSA            Unreviewed;      4942 AA.
AC   H2Y875;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001523};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001523, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001523}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001523}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001523}.
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DR   Ensembl; ENSCSAVT00000001543; ENSCSAVP00000001523; ENSCSAVG00000000873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4336   4356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4505   4526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4566   4585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4683   4702       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4745   4765       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4819   4842       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      339    396       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    797       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1007   1200       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4942 AA;  559944 MW;  5C6DE4A1D59E7CC3 CRC64;
     PSDVTMDGDG DEEVHFLRTE DEIYLQCVTQ KDHQGKLCLA AEGFGNRLCY VEQSHEDKDS
     RPTDAPRCVF VLAQALSVRA LQELLAKDEV KDGSTHSRTL LYGNAVQLKH GLSAMYLTCL
     TTASSSCDKL AFDVGISEDQ SGEASWWTVH PTSKQRSEGE KVRIGDDLIL ISIASERYLH
     LSCGDPGGVN VEASFQHSMW TVAPIASGGS KVEGYLTGGD VIRLFHGHMD DCLTVDSAEE
     MKSHTRPIVY ESGRAGSHAR SLWRLELLQI KWFGSHVAWG IPFRLRHITS GLYLSVMDDQ
     SLGLTSPEGA TYRTAVFCWQ ASKDRPESKA DHEIDGMGAP EIKYGDSVCY LQHVDSGLWM
     TYQTIDTKSG RCGPKQRMAV LHDDGRMDDG FMLSRAHPGE ARTATIIRRT TEIFCNFINA
     LDSHQNKKMS RRPEQPNVEE VEQCVDDLIE YFQEGRGEEG GHEVHQHIVQ ELKNRQDLFQ
     EEDAVSHVLQ CIDKLAVYGD AGNFAQIVGV EASASYESLL NSMYVLLAAT VRGNRNNCSK
     FAPHLDWLVG QLDGQQAAMG ILEVLAAVLE DSQEALNMMK QDHIRSIISL LEKQCRNPKV
     LEVLSSLCVC NGVAVRGNQN LICETLLPGR DLLLQTALQS YITNVQPNIY MGVSNACAQY
     KKWYYEVIVE AVDRSTFAGH LRVGWANTEG FSPYPVGGDY YGENGVGDDM HSFGFDGINL
     WTSHRACPVG SNNRHILAPN DIISCCMDLS IPTISFRING QPVQGMFEDF NLNGLFFPVV
     SFSPGVKVRF LFGGPHGEFR FLPPVGYAPA YEALLPGRRL FLSPCKTYGN LSRGHLMGPG
     SSWERTVLFY RTTCKTLSPN WTESIHELWA MNRIRGGWSY GTVRDEAKKQ NPCLVEFARL
     PEQERSFNLT MSYETLRTII ALGYHVGIAD EEAEHGLRKL KLPRSYIMAS GYKPSPLDLS
     HVKLTNQMED LVEKLADNAH NVWARERVKQ GWTYGVNLDV GKKRNPRLVP FQLLDELAKQ
     SNRNSIRELV RTLIGHGYMI EPPDDRLKDK TTRIKNPVQN NKVRIFRAEK THSVCAGKWY
     FEFTIETQGV MKVGWVDPDC LPSVDLGSNH QAYVFDGVNA LKLNDGSETF GQRWKPGDVV
     GCLLDFSERK IFFSLNGELL VDRCGHETAF RNLPSDLTLV PAVSLSVDQR GTLNLGKDPD
     SFQFYSTVGQ KEGYQPFAAG MRCGVAMWFT KNLPSFCNLD PVHGNIEVKR LSASHHKPPR
     LKVMYKLIGG SRSHDHQEWV YTRLNLPVST DAVFTKRLMR YTNLMFAQIS TAISRFCGRL
     REEASPPSPI MTSRTNVIII TSTPCPSQVT HHPNTPSPHI PLTPTQPPTP IPTPHTHPNA
     SVSRYMKVFR LKRCLTHTWS STPPVWGDQD NQRRPYLVNK VKPGLKGSKF HFSRTKTSNA
     HVGSNQANQS KPRLAEEVLP DHYNEVLYKN DIDQVYFKHK CETDLNQSHH RSIIIIDVCT
     LRIFYLMRST QYSFSVRIFP EQDLGSLYVG WVTSDFHWNV DNFQRGLIPT VTITLGDNKG
     KISERYLRSN CFVLCCGDLP QQAMPPNQSS PGIVVTCIID TATGLLTFAA NGSDLNTFFQ
     VEPNVELYPA VIALPTAHNI FQYELGRTKH IMPLSAAVLK CERKNVVPQC PPRLQVQTLE
     QVSWTRMPGR LPRPECRRDM DRTKGWTSES KSSDSDAYNV VVVHIPEENR CIDLLELGEN
     ADLLRFHERT LKLYSSMCAL GNHRVAHALC SYIDEKQLMR IIRTEGLVGS VRAAYHDLLI
     EMHLSPHANA RRNTQHEYMF PLNDNTQSIG LFSDPASKRP MVPGVGPSSS IRPTLHWSPI
     NVVMHLIHDV PLEVPEFPLD ELRQNVIGQL HEAIRACYRK CKDSTGKNQE YLLVPPLRLA
     LTLLTMGVFN DEDITKLLIL LAPSFIRTLV EDENSHCGLL GLQLVESVKL EACLLLEHLM
     ELVLRHRVEA LVSFSCVIVE ELQQDQKSRY QGVMEAINMS AAMTAKMTRE FRSPPLEQMA
     ILLKFKSEEL EENCPLPQHI KDLLWNFHTD MLLDCGEQIE EEPVEEDNQD TLRSKLSSIV
     SRILHKRKEE EESPEESSHA TVGGGSFRDL IISTMMGWAR GPSINNPQLV RAIFRLLYRQ
     YNGVGEMQNA LMKTYCISAA SEGDTMALLE SLSRLRSLLS VQLGQDEETL IIKGLNSIMN
     NKVFYQHPNL MRILCMHETV MEVMVSVLDG DGDSDSIEVK FPRMVAACCR FLCYFCRISR
     LNQGAMFEHL GFLLEHSSVG LATPSMRGST PLDVAAASVM DNNELALALK ESDLAKVNLA
     LATCGVESSQ LLLRKGYPDI GWNPVEGERY LDFLKNAVFV NGESVEENAN LVVRQLIRQT
     ECLGPSLRGE GGHGLLAAIT SALQICRDRS RDGPDLNFNE YDNDDDIHMG FSILAFYSTL
     IDLLGRCAPE KYLIMQGKSD AIRIRSILRS LVPREDLIGV ISLPFDLPRF ERGSTNIREP
     DLSACFIPDH KASMVLFLER VYGIDSPHLL LRLLESGLLP DMKSAAQLDV PHINSTDMAL
     ALNRYMCHSV LPLLVKHVSL LAHCQHRPQL LDQLLHTIYR MSQAQALTKA QKEMISECLV
     AVASVLQPSL LQGLLRKLTF DVPALTEETY IPLQLLKEHY SRCWKYYYLL EGCPDFGVAT
     DEEKHITMVL FWGIFDSLVK KPYSQELFSK VLPCLCSIGN ALPPDYALSP ALEKLHQQSS
     IDSHGKFHPQ PVDTKSILFP EKLDVFVNKC SEQWHDTWAL ERFTLGWSYE AHYNEALKQH
     PMLKPYRLLN DREKDVYRPS VREGIKALIA WGWSFKKIVE ATDISQLPAK TASDAHGYLP
     RPYDLSGVSL GREMMRTAEM LAENFHLVWA RKKMGELESK HTNLPSHPML VPYDRLTAKE
     KERDRGKAYD LLKFFQFNNY VMSKAEKEEV DVKSSVEKRF SSMVLQRLLS YVQQVSYVQQ
     VSYVQWVSYV QHVSYPQAND DIKFFAKVAM PLMESYFKNQ EIYYVEACGN ANDGIACRKP
     NAFILSRLFC KMALLIRQRI TMFGVDAGTA INCVKILAEC IDASTITKAC SESMKQALIS
     FFNNAADDLK LMLNHIRSGR IKILQTMVAG AHTSNYVSHC LLPLLTILFR HLGRHNFGGE
     LLLDEIQVSC YKILNGLYSL GTGKSAFIDR SSSTNNYSPS HRAQVGECLA AFASAFPVSF
     LEPKLNKFNS YSIYNILSIK DRKALGLPPN LEQLTPHLPI LETLLADINH LADSGAKYEE
     APEMIDIILP LICSYLPPWL KQGPDDNSAV STGFSSSVSS KVLDVVLRDV LRLIHNNLGT
     DEADWMRRIA VYTQPIMVRS DPDLLADHFL PMIIKLSKRI EQARDLEEQV MNDVSDLELL
     MLEDYGIISR DLYAFYPLMV RYIDLSKSCW IRERNPIALQ LFRIISKIMI IWSKSINFRR
     EEQNFVVQNE IDNMSVLTAD KSATPSAASI QRVVKRRGDR YSPSTSLVVA CLKRMMPVAI
     NTGHVADFQL LQEAKSRFVQ RDTEDDIREY LVQVLNVSCL SLPQLNCFVR LHSFMSFQSE
     GTSTNESQDK VESRADWLLE IARAQHYLFM SRRAVWKKLM SKQRKRAVVS CFRMVPLYNL
     PKHRVSNCFL SNYMEKWLNS EDQDKCGLIE IITVYCTLVP LCATCLLGLP APLLLDRMFV
     EGESGGSDPL QQLISVFSIS AITSLIHRAI EDDDLYLSYA ELMAESCHTG DDDDEEEEKS
     FEEKEKEKQR LLYEQKRLAT RGVAEMVLYM ISASGGEVSD TVLSTLQLGI ALLTGGNVLV
     QKTMLAHLQA KKDVRFFTSL AGLMQQCSVL DLNAYERCLK SESLGHASEG TVTGGETMGD
     AELTCALFRF LQLLCEGHNG DFQNYLRSQV GNNTTVNIII STVDYLLRLQ EAITDFYWYY
     SAKDTIDAPG RENFSKAIEV AKQVFNSLTE YIQGPCEGNQ QALAHSRLWD AVVGFLHVFA
     HMQMKLAQDS TRQLSLLKEL LDLQQDMIVM LLSMLEGNVV NGTIGKQLVD TLIESSHNVG
     LILKFFNMFL RLKDITESEK FTEYDPEHNG VVSRRDFHKA MEASKVYSRE EIDFLLRCAV
     TTDDDKLNYM DFTEQFHGPA ADIGFNMAVL LTNLSEHMPH DTRLGKFLEM AEAMLEYFQP
     NLGRIEIVGG ARRIERVYFN IRPSSLEQWQ KPQVQESKRQ FFFDVINDEG EGGRMEEFVN
     FCEDTIFEVD ATCITDNPSP SQITLVYRSN HIPPQMQLAS QISETGFGSS STGPTNDDVD
     DEDVETMLWG MTWMELLKTF FFFLLASSFQ LFHGHAEYDR IRLRQRVQHT TSNSDQETEE
     IIAQRKETRS NIKHNQLACE LMNLMEHGCS LLRSHIGVNA IFPQLSSHYS EHPDAQEAST
     LSRTMSFDMT TADDSSCTPW QSCMSACGRP ARYKQQEIVE DKNAAYLDCL NSFCMGTLGL
     FARNFYNFKI LALIITFIIN FFLLFYKVSG CDKSYWQSIN EDLDVDESER LVLVDTTLYM
     EPALKIFRAI HFILSFSMLV SYYGLKVPLV IFKREKEIAR KLEFGGLYVS EDPSDDDLSG
     RWDRLVVSAP SFPSNYWDKF IKKKVLDKFG EQCGVERIRE LLGMSESSTS FATSSHMDLK
     YTIWKVGVVF CDQSFLYLLW YFTMSIFGQY NHFFFSLHLL DIAACSKGLR TILTSVTHNG
     KQLVLTIGLL TVVVYLYTVV AFNFFKKFYN KGENDEDDWK CNSMFTCFQF HFYSGVRAGG
     GIGDELDDPS GDAWEFYRIA FDISFFFFVI VILLAIIQGL IIDAFGELRD QQEQVKEDMD
     TKCFICTIGI DYFDQVPHGF ESHTMQEHNL ANYMFFLMHL INKDETEHTG QETYVWQQYQ
     ERCWEFFPAG DCFRKQYENE LS
//
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