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Database: UniProt
Entry: H2Y877_CIOSA
LinkDB: H2Y877_CIOSA
Original site: H2Y877_CIOSA 
ID   H2Y877_CIOSA            Unreviewed;      4978 AA.
AC   H2Y877;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   22-NOV-2017, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001525};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001525, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001525}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001525}.
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DR   Ensembl; ENSCSAVT00000001545; ENSCSAVP00000001525; ENSCSAVG00000000873.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4348   4367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4530   4550       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4590   4609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4719   4738       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4781   4801       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4855   4878       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      158    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    323       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      587    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1021   1214       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4978 AA;  563168 MW;  7264B44AF1F3F501 CRC64;
     SDVTMDGDGD EEVHFLRTED EIYLQCVTQK DHQGKLCLAA EGFGNRLCYV EQSHEDKDSR
     PTDAPRCVFV LAQALSVRAL QELLAKDEVK DGSTHSRTLL YGNAVQLKHG LSAMYLTCLT
     TASSSCDKLA FDVGISEDQS GEASWWTVHP TSKQRSEGEK VRIGDDLILI SIASERYLHL
     SCGDPGGVNV EASFQHSMWT VAPIASGGSK VEGYLTGGDV IRLFHGHMDD CLTVDSAEEM
     KSHTRPIVYE SGRAGSHARS LWRLELLQIK WFGSHVAWGI PFRLRHITSG LYLSVMDDQS
     LGLTSPEGAT YRTAVFCWQA SKDRPESKAD HEIDGMGAPE IKYGDSVCYL QHVDSGLWMT
     YQTIDTKSGR CGPKQRMAVL HDDGRMDDGF MLSRAHPGEA RTATIIRRTT EIFCNFINAL
     DSHQNKKMSR RPEQPNVEEV EQCVDDLIEY FQEGRGEEGG HEVHQHIVQE LKNRQDLFQE
     EDAVSHVLQC IDKLAVYGDA GNFAQIVGVE ASASYESLLN SMYVLLAATV RGNRNNCSKF
     APHLDWLVGQ LDGQQAAMGR HVRLGILEVL AAVLEDSQEA LNMMKQDHIR SIISLLEKQC
     RNPKVLEVLS SLCVCNGVAV RGNQNLICET LLPGRDLLLQ TALQSYITNV QPNIYMGVSN
     ACAQYKKWYY EVIVEAVDRS TFAGHLRVGW ANTEGFSPYP VGGDYYGENG VGDDMHSFGF
     DGINLWTSHR ACPVGSNNRH ILAPNDIISC CMDLSIPTIS FRINGQPVQG MFEDFNLNGL
     FFPVVSFSPG VKVRFLFGGP HGEFRFLPPV GYAPAYEALL PGRRLFLSPC KTYGNLSRGH
     LMGPGSSWER TVFVPNAVNT QNVILSHYLQ NVVPKLESIH ELWAMNRIRG GWSYGTVRDE
     AKKQNPCLVE FARLPEQERS FNLTMSYETL RTIIALGYHV GIADEEAEHG LRKLKLPRSY
     IMASGYKPSP LDLSHVKLTN QMEDLVEKLA DNAHNVWARE RVKQGWTYGV NLDVGKKRNP
     RLVPFQLLDE LAKQSNRNSI RELVRTLIGH GYMIEPPDDR LKDKTTRIKN PVQNNKVRIF
     RAEKTHSVCA GKWYFEFTIE TQGVMKVGWV DPDCLPSVDL GSNHQAYVFD GVNALKLNDG
     SETFGQRWKP GDVVGCLLDF SERKIFFSLN GELLVDRCGH ETAFRNLPSD LTLVPAVSLS
     VDQRGTLNLG KDPDSFQFYS TVGQKEGYQP FAAGMRCGVA MWFTKNLPSF CNLDPVHGNI
     EVKRLSASHH KPPRLKVMYK LIGGSRSHDH QEWVYTRLNL PVSTDAVFTK RLMRYTNLMF
     AQISTAISRF CGRLREEASP PSPIMTSRTN VIIITSTPCP SQVTHHPNTP SPHIPLTPTQ
     PPTPIPTPHT HPNASVSRYM KVFRLKRCLT HTWSSTPPVW GDQDNQRRPY LVNKVKPGSK
     FHFSRTKTSN AHVGSNQANQ SKPRLAEEVL PDHYNEVLYK NDIDQLMRST QYSFSVRIFP
     EQDLGSLYVG WVTSDFHWNV DNFQRGLIPT VTITLGDNKG KISERYLRSN CFVLCCGDLP
     QQAMPPNQSS PGIVVTCIID TATGLLTFAA NGSDLNTFFQ VEPNVELYPA VIALPTAHNI
     FQYELGRTKH IMPLSAAVLK CERKNVVPQC PPRLQVQTLE QVSWTRMPGR LPRPECRRDM
     DRTKGWTSES KSSDSDAYNV VVVHIPEENR CIDLLELGEN ADLLRFHERT LKLYSSMCAL
     GNHRVAHALC SYIDEKQLMR IIRTEGLVGS VRAAYHDLLI EMHLSPHANA RRNTQHEYMF
     PLNDNTQSIG LFSDPASKRP MVPGVGPSSS IRPTLHWSPI NVVMHPSLIH DVPLEVPEFP
     LDELRQNVIG QLHEAIRACY RKCKDSTGKN QEYLLVPPLR LALTLLTMGV FNDEDITKLL
     ILLAPSFIRT LVEDESLSDS HCGLLGLQLV ESVKLEACLL LEHLMELVLR HRVEALVSFS
     CVIVEELQQD QKSRYQGVME AINMSAAMTA KMTREFRSPP LEQMAILLKF KSEELEENCP
     LPQHIKDLLW NFHTDMLLDC GEQIEEEPVE EDNQDTLRSK LSSIVSRILH KRKEEEESPE
     ESSHATVGGG SFRDLIISTM MGWARGPSIN NPQLVRAIFR LLYRQYNGVG EMQNALMKTY
     CISAASEGDT MALLESLSRL RSLLSVQLGQ DEETLIIKGL NSIMNNKVFY QHPNLMRILC
     MHETVMEVMV SVLDGDGDSD SIVKFPRMVA ACCRFLCYFC RISRLNQGAM FEHLGFLLEH
     SSVGLATPSM RGSTPLDVAA ASVMDNNELA LALKESDLAK VNLALATCGV ESSQLLLRKG
     YPDIGWNPVE GERYLDFLKN AVFVNGESVE ENANLVVRQL IRQTECLGPS LRGEGGHGLL
     AAITSALQIC RDRSRDGPDL NLCNEYDNDD DIHMGFSILA FYSTLIDLLG RCAPEKYLIM
     QGKSDAIRIR SILRSLVPRE DLIGVISLPF DLPRFERGST NIREPDLSAC FIPDHKASMV
     LFLERVYGID SPHLLLRLLE SGLLPDMKSA AQLDVPHINS TDMALALNRY MCHSVLPLLV
     KHVSLLAHCQ HRPQLLDQLL HTIYRMSQAQ ALTKAQKEMI SECLVAVASV LQPSLLQGLL
     RKLTFDVPAL TEETYIPLQL LKEHYSRCWK YYYLLEGCPD FGVATDEEKH ITMVLFWGIF
     DSLVKKPYSQ ELFSKVLPCL CSIGNALPPD YALSPALEKL HQQSSIDSHG KFHPQPVDTK
     SILFPEKLDV FVNKCSEQWH DTWALERFTL GWSYEAHYNE ALKQHPMLKP YRLLNDREKD
     VYRPSVREGI KALIAWGWSF KKIVEATDIS QLPAKVRCSS QSNIVISIIS QTASDAHGYL
     PRPYDLSGVS LGREMMRTAE MLAENFHLVW ARKKMGELES KHTNLPSHPM LVPYDRLTAK
     EKERDRGKAY DLLKFFQFNN YVMSKAEKEE VDVKSSVEKR FSSMVLQRLL SYVQQVSYVQ
     QVSYVQWVSY VQHVSYPQAN DDIKFFAKVA MPLMESYFKN QEIYYVEACG NANDGIACRK
     PNAFILSRLF CKMALLIRQR ITMFGVDAGT AINCVKILAE CIDASTITKA CSESMKQALI
     SFFNNAADDL KLMLNHIRSG RIKILQTMVA GAHTSNYVSH CLLPLLTILF RHLGRHNFGG
     ELLLDEIQVS CYKILNGLYS LGTGKSAFID RHRAQVGECL AAFASAFPVS FLEPKLNKFN
     SYSIYNILSI KDRKALGLPP NLEQLTPHLP ILETLLADIN HLADSGAKYE EAPEMIDIIL
     PLICSYLPPW LKQGPDDNSA VSTGFSSSVS SKVLDVVLRD VLRLIHNNLG TDEADWMRRI
     AVYTQPIMVR SDPDLLADHF LPMIIKLSKR IEQARDLEEQ VKYDQRVNDV SDLELLMLED
     YGIISRDLYA FYPLMVRYID LSKSCWIRER NPIALQLFRI ISKIMIIWSK SINFRREEQN
     FVVQNEIDNM SVLTADKSAT PSAASMLVSK HCSLQASQRV VKRRGDRYSP STSLVVACLK
     RMMPVAINTG HVADFQLLQE AKSRFVQRDT EDDIREYLVQ VLNVSCLSLW LGTQVHWHLR
     LPQLNCFVRL HSFMSFQSEG TSTNESQDKV ESRADWLLEI ARAQHYLFMV DHPPKSRRAV
     WKKLMSKQRK RAVVSCFRMV PLYNLPKHRV SNCFLSNYME KWLNSEDQDK CGLIEIITPS
     VEGESGGSDP LQQLISVFSI SAITSLIHRA IEDDDLYLSY AELMAESCHT GDDDDEEEEK
     SFEVSEGVYV SLQEKEKEKQ RLLYEQKRLA TRGVAEMVLY MISASGGEVS DTVLSTLQLG
     IALLTGGNVL VQKTMLAHLQ AKKDVRFFTS LAGLMQQCSV LDLNAYERCL KSESLGHASE
     GTVTGGETMG DAELTCALFR FLQLLCEGHN GDFQNYLRSQ VGNNTTVNII ISTVDYLLRL
     QEAITDFYWY YSAKDTIDAP GRENFSKAIE VAKQVFNSLT EYIQGPCEGN QQALAHSRLW
     DAVVGFLHVF AHMQMKLAQD STRQLSLLKE LLDLQQDMIV MLLSMLEGNV VNGTIGKQLV
     DTLIESSHNV GLILKFFNMF LRLKDITESE KFTEYDPEHN GVVSRRDFHK AMEASKVYSR
     EEIDFLLRCA VTTDDDKLNY MDFTEQFHGP AADIGFNMAV LLTNLSEHMP HDTRLGKFLE
     MAEAMLEYFQ PNLGRIEIVG GARRIERVYF NIRPSSLEQW QKPQVQESKR QFFFDVINDE
     GEGGRMEEFV NFCEDTIFEV GGGNLFLRVM DLFNYMNESY ATCITDNPSP SQITLVVSYN
     LYLNFLCNLH HKSARPGSEA APLDQPTMML MMKILMFIVF FSNKLVVALK SKRVSEVVGE
     MPSPTQHGVE DGVLDEDASD ASDPLKSDRD DLIVDVFGMD IKKGKELMKA VVHTKREAGF
     GDFSVEEAAD TLTGSTHHEQ LGSRNGGNYC AKEGDSVKHQ AQPARFRTMS FDMTTADDSS
     CTPWQSCMSA CGRPARYKQQ EIGLFARNFY NFKILALIIT FIINFFLLFY KVSGCDKSYW
     QSINEDLDVD ESERLVLVDT TLYMEPALKI FRAIHFILSF SMLVSYYGLK VPLVIFKREK
     EIARKLEFGG LYVSEDPSDD DLSGRWDRLV VSAPSFPSNY WDKFIKKKVL DKFGEQCGVE
     RIRELLGMSE SSTSFVEDEE PIKGNIITQL LKVDLKYTIW KVGVVFCDQS FLYLLWYFTM
     SIFGQYNHFF FSLHLLDIAA CSKGLRTILT SVTHNGKQLV LTIGLLTVVV YLYTVVAFNF
     FKKFYNKGEN DEDDWKCNSM FTCFQFHFYS GVRAGGGIGD ELDDPSGDAW EFYRIAFDIS
     FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMDTKCF ICTIGIDYFD QVPHGFESHT
     MQEHNLANYM FFLMHLINKD ETEHTGQETY VWQQYQERCW EFFPAGDCFR KQYENELS
//
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