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Database: UniProt
Entry: H2Y878_CIOSA
LinkDB: H2Y878_CIOSA
Original site: H2Y878_CIOSA 
ID   H2Y878_CIOSA            Unreviewed;      4962 AA.
AC   H2Y878;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   10-MAY-2017, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001526};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001526, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001526}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001526}.
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DR   Ensembl; ENSCSAVT00000001546; ENSCSAVP00000001526; ENSCSAVG00000000873.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4328   4346       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4514   4534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4574   4593       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4703   4722       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4765   4785       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4839   4862       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      579    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4962 AA;  561828 MW;  041BCC1D11231F66 CRC64;
     VTMDGDGDEE VHFLRTEDEI YLQCVTQKDH QGKLCLAAEG FGNRLCYVEQ SHEDKDSRPT
     DAPRCVFVLA QALSVRALQE LLAKDEVKDG STHSRTLLYG NAVQLKHGLS AMYLTCLTTA
     SSSCDKLAFD VGISEDQSGE ASWWTVHPTS KQRSEGEKVR IGDDLILISI ASERYLHLSC
     GDPGGVNVEA SFQHSMWTVA PIASGGSKVE GYLTGGDVIR LFHGHMDDCL TVDSAEEMKS
     HTRPIVYESG RAGSHARSLW RLELLQIKWF GSHVAWGIPF RLRHITSGLY LSVMDDQSLG
     LTSPEGATYR TAVFCWQASK DRPESKADHE IDGMGAPEIK YGDSVCYLQH VDSGLWMTYQ
     TIDTKSGRCG PKQRMAVLHD DGRMDDGFML SRAHPGEART ATIIRRTTEI FCNFINALDS
     HQNKKMSRRP EQPNVEEVEQ CVDDLIEYFQ EGRGEEGGHE VHQHIVQELK NRQDLFQEED
     AVSHVLQCID KLAVYGDAGN FAQIVGVEAS ASYESLLNSM YVLLAATVRG NRNNCSKFAP
     HLDWLVGQLD GQQAAMGILE VLAAVLEDSQ EALNMMKQDH IRSIISLLEK QCRNPKVLEV
     LSSLCVCNGV AVRGNQNLIC ETLLPGRDLL LQTALQSYIT NVQPNIYMGV SNACAQYKKW
     YYEVIVEAVD RSTFAGHLRV GWANTEGFSP YPVGGDYYGE NGVGDDMHSF GFDGINLWTS
     HRACPVGSNN RHILAPNDII SCCMDLSIPT ISFRINGQPV QGMFEDFNLN GLFFPVVSFS
     PGVKVRFLFG GPHGEFRFLP PVGYAPAYEA LLPGRRLFLS PCKTYGNLSR GHLMGPGSSW
     ERTVFVPNAV NTQNVILSHY LQNVVPKLES IHELWAMNRI RGGWSYGTVR DEAKKQNPCL
     VEFARLPEQE RSFNLTMSYE TLRTIIALGY HVGIADEEAE HGLRKLKLPR SYIMASGYKP
     SPLDLSHVKL TNQMEDLVEK LADNAHNVWA RERVKQGWTY GVNLDVGKKR NPRLVPFQLL
     DELAKQSNRN SIRELVRTLI GHGYMIEPPD DRLKDKTTRI KNPVQNNKVR IFRAEKTHSV
     CAGKWYFEFT IETQGVMKVG WVDPDCLPSV DLGSNHQAYV FDGVNALKLN DGSETFGQRW
     KPGDVVGCLL DFSERKIFFS LNGELLVDRC GHETAFRNLP SDLTLVPAVS LSVDQRGTLN
     LGKDPDSFQF YSTVGQKEGY QPFAAGMRCG VAMWFTKNLP SFCNLDPVHG NIEVKRLSAS
     HHKPPRLKVM YKLIGGSRSH DHQEWVYTRL NLPVSTDAVF TKRLISTAIS RFCGRLREEA
     SPPSPIMTSR TNVIIITSTP CPSQVTHHPN TPSPHIPLTP TQPPTPIPTP HTHPNASVSR
     YMKVFRLKRC LTHTWSSTPP VKPRLAEEVL PDHYNEVLYK NDIDQLMRST QYSFSVRIFP
     EQDLGSLYVG WVTSDFHWNV DNFQRGLIPT VTITLGDNKG KISERYLRSN CFVLCCGDLP
     QQAMPPNQSS PGIVVTCIID TATGLLTFAA NGSDLNTFFQ VEPNVELYPA VIALPTAHNI
     FQYELGRTKH IMPLSAAVLK CERKNVVPQC PPRLQVQTLE QVSWTRMPGR LPRPECRRDM
     DRTKGWTSES KSSDSDAYNV VVVHIPEENR CIDLLELGEN ADLLRFHERT LKLYSSMCAL
     GNHRVAHALC SYIDEKQLMR IIRTEGLVGS VRAAYHDLLI EMHLSPHANA RNTQHEYMFP
     LNDNTQSIGL FSDPASKRPM VPGVGPSSSI RPTLHWSPIN VVMHLIHDVP LEVPEFPLDE
     LRQNVIGQLH EAIRACYRKC KDSTGKNQEY LLVPPLRLAL TLLTMGVFND EDITKLLILL
     APSFIRTLVE DESLSGEYIL PMPFSTHTPP PFLTPHCPTI FQPHNPHNNP LIILNPPPPP
     HPHRIEDSHC GLLGLQLVES VKLEACLLLE HLMELVLRHR VEALVSFSCV IVEELQQDQK
     SRYQGVMEAI NMSAAMTAKM TREFRSPPLE QMAILLKFKS EELEENCPLP QHIKDLLWNF
     HTDMLLDCGE QIEEEPVEED NQDTLRSKLS SIVSRILHKR KEEEESPEES SHATVGGGSF
     RDLIISTMMG WARGPSINNP QLVRAIFRLL YRQYNGVGEM QNALMKTYCI SAASEGDTMA
     LLESLSRLRS LLSVQLGQDE ETLIIKGLNS IMNNKVFYQH PNLMRILCMH ETVMEVMVSV
     LDGDGDSDSI VKFPRMVAAC CRFLCYFCRI SRLNQGAMFE HLGFLLEHSS VGLATPSMRG
     STPLDVAAAS VMDNNELALA LKESDLAKLV EQLATCGVES SQLLLRKGYP DIGWNPVEGE
     RYLDFLKNAV FVNGESVEEN ANLVVRQLIR QTECLGPSLR GEGGHGLLAA ITSALQICRD
     RSRDGPDLNF NEYDNDDDIH MGFSILAFYS TLIDLLGRCA PEKYLIMQGK SDAIRIRSIL
     RSLVPREDLI GVISLPFDLP RFERGSTNIR EPDLSACFIP DHKASMVLFL ERVYGIDSPH
     LLLRLLESGL LPDMKSAAQL DVPHINSTDM ALALNRYMCH SVLPLLVKHV SLLAHCQHRP
     QLLDQLLHTI YRMSQAQALT KAQKEMISEC LVAVASVLQP SLLQGLLRKL TFDVPALTEE
     TYIPLQLLKE HYSRCWKYYY LLEGCPDFGV ATDEEKHITM VLFWGIFDSL VKKPYSQELF
     SKVLPCLCSI GNALPPDYAL SPALEKLHQQ SSIDSHGKFH PQPVDTKSIL FPEKLDVFVN
     KCSEQWHDTW ALERFTLGWS YEAHYNEALK QHPMLKPYRL LNDREKDVYR PSVREGIKAL
     IAWGWSFKKI VEATDISQLP AKVRCSSQSN IVISSDAHGY LPRPYDLSGV SLGREMMRTA
     EMLAENFHLV WARKKMGELE SKHTNLPSHP MLVPYDRLTA KEKERDRGKA YDLLKFFQFN
     NYVMSKAEKE EVDVKSSVEK RFSSMVLQRL LSYVQQRQQE HAAFGGNYEP PSLQQPQAND
     DIKFFAKVAM PLMESYFKNQ EIYYVEACGN ANDGIACRKP NAFILSRLFC KMALLIRQRI
     TMFGVDAGTA INCVKILAEC IDASTITKAC SESMKQALIS FFNNAADDLK LMLNHIRSGR
     IKILQTMVAG AHTSNYVSHC LLPLLTILFR HLGRHNFGGE LLLDEIQVSC YKILNGLYSL
     GTGKSAFIDR HRAQVGECLA AFASAFPVSF LEPKLNKFNS YSIYNILSIK DRKALGLPPN
     LEQLTPHLPI LETLLADINH LADSGAKYEE APEMIDIILP LICSYLPPWL KQGPDDNSAV
     STGFSSSVSS KVLDVVLRDV LRLIHNNLGT DEADWMRRIA VYTQPIMVRS DPDLLADHFL
     PMIIKLSKRI EQARDLEEQV KYDQRVNDVS DLELLMLEDY GIISRDLYAF YPLMVRYIDL
     SKSCWIRERN PIALQLFRII SKIMIIWSKS INFRREEQNF VVQNEIDNMS VLTADKSATP
     SAASMLVSKH CSLQASQRVV KRRGDRYSPS TSLVVACLKR MMPVAINTGH VADFQLLQEA
     KSRFVQRDTE DDIREYLVQV LNVSDTTWRP QLNCFVRLHS FMSFQSEGTS TNESQDKVES
     RADWLLEIAR AQHYLFMVDH PPKSRRAVWK KLMSKQRKRA VVSCFRMVPL YNLPKHRVSN
     CFLSNYMEKW LNSEDQDKCG LIEIITPSVE GESGGSDPLQ QLISVFSISA ITSLIHRAIE
     DDDLYLSYAE LMAESCHTGD DDDEEEEKSF EVCVYVSLQE KEKEKQRLLY EQKRLATRGV
     AEMVLYMISA SGGEVSDTVL STLQLGIALL TGGNVLVQKT MLAHLQAKKD VRFFTSLAGL
     MQQCSVLDLN AYERCLKSES LGHASEGTVT ETMGDAELTC ALFRFLQLLC EGHNGDFQNY
     LRSQVGNNTT VNIIISTVDY LLRLQEAITD FYWYYSAKDT IDAPGRENFS KAIEVAKQVF
     NSLTEYIQGP CEGNQQALAH SRLWDAVVGF LHVFAHMQMK LAQDSTRQLS LLKELLDLQQ
     DMIVMLLSML EGNVVNGTIG KQLVDTLIES SHNVGLILKF FNMFLRLKDI TESEKFTEYD
     PEHNGVVSRR DFHKAMEASK VYSREEIDFL LRCAVTTDDD KLNYMDFTEQ FHGPAADIGF
     NMAVLLTNLS EHMPHDTRLG KFLEMAEAML EYFQPNLGRI EIVGGARRIE RVYFNIRPSS
     LEQWQKPQVQ ESKRQFFFDV INDEGEGGRM EEFVNFCEDT IFEMQLASQI SETGFGSSST
     GPTNDDVDDE DVETISDDFT PHINMKSIKH QAKRLWGMTW MELLKTFFFF LLASSFQLFQ
     YGIDTLRYLW SLMFIVFFSN KLVVALKSKR VSEVVGEMPS PTQHGVEDGV KGKELMKAVV
     HTKREAGFGD FSVEEAADTL SMIASDYDSG FNTPRATRIK KRRKLLRKGR RLGQTSSTTS
     SLLSSHYSEH PDAQEASTLS RTMSFDMTTA DDSSCTPWQS CMSACGRPAR YKQQEIETFK
     STSHSQGLFA RNFYNFKILA LIITFIINFF LLFYKVSGCD KSYWQSINED LDVDESERLV
     LVDTTLYMEP ALKIFRAIHF ILSFSMLVSY YGLKVPLVIF KREKEIARKL EFGGLYVSED
     PSDDDLSGRW DRLVVSAPSF PSNYWDKFIK KKVLDKFGEQ CGVERIRELL GMSESSTSFV
     EDEEPIKGNI ITQLLKVDLK YTIWKVGVVF CDQSFLYLLW YFTMSIFGQY NHFFFSLHLL
     DIAACSKGLR TILTSVTHNG KQLVLTIGLL TVVVYLYTVV AFNFFKKFYN KGENDEDDWK
     CNSMFTCFQF HFYSGVRAGG GIGDELDDPS GDAWEFYRIA FDISFFFFVI VILLAIIQGL
     IIDAFGELRD QQEQVKEDMD TKCFICTIGI DYFDQVPHGF ESHTMQEHNL ANYMFFLMHL
     INKDETEHTG QETYVWQQYQ ERCWEFFPAG DCFRKQYENE LS
//
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