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Database: UniProt
Entry: H2Y879_CIOSA
LinkDB: H2Y879_CIOSA
Original site: H2Y879_CIOSA 
ID   H2Y879_CIOSA            Unreviewed;      4897 AA.
AC   H2Y879;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001527};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001527, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001527}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001527}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001527}.
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DR   Ensembl; ENSCSAVT00000001547; ENSCSAVP00000001527; ENSCSAVG00000000873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4268   4286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4448   4468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4508   4527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4637   4656       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4699   4720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4774   4797       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      595    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1029   1222       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4897 AA;  554319 MW;  6DEDFE4D2EC90B01 CRC64;
     VTMDGDGDEE VHFLRTEDEI YLQCVTQKDH QGKLCLAAEG FGNRLCYVEQ SHEDKDSRPT
     DAPRCVFVLA QALSVRALQE LLAKDEVKEA QQSIVSGEDQ ARREDGSTHS RTLLYGNAVQ
     LKHGLSAMYL TCLTTASSSC DKLAFDVGIS EDQSGEASWW TVHPTSKQRS EGEKVRIGDD
     LILISIASER YLHLSCGDPG GVNVEASFQH SMWTVAPIAS GGSKVEGYLT GGDVIRLFHG
     HMDDCLTVDS AEEMKSHTRP IVYESGRAGS HARSLWRLEL LQIKWFGSHV AWGIPFRLRH
     ITSGLYLSVM DDQSLGLTSP EGATYRTAVF CWQASKDRPE SKADHEIDGM GAPEIKYGDS
     VCYLQHVDSG LWMTYQTIDT KSGRCGPKQR MAVLHDDGRM DDGFMLSRAH PGEARTATII
     RRTTEIFCNF INALDSHQNK KMSRRPEQPN VEEVEQCVDD LIEYFQEGRG EEGGHEVHQH
     IVQELKNRQD LFQEEDAVSH VLQCIDKLAV YGDAGNFAQI VGVEASASYE SLLNSMYVLL
     AATVRGNRNN CSKFAPHLDW LVGQLDGQQA AMGILEVLAA VLEDSQEALN MMKQDHIRSI
     ISLLEKQCRN PKVLEVLSSL CVCNGVAVRG NQNLICETLL PGRDLLLQTA LQSYITNVQP
     NIYMGVSNAC AQYKKWYYEV IVEAVDRSTF AGHLRVGWAN TEGFSPYPVG GDYYGENGVG
     DDMHSFGFDG INLWTSHRAC PVGSNNRHIL APNDIISCCM DLSIPTISFR INGQPVQGMF
     EDFNLNGLFF PVVSFSPGVK VRFLFGGPHG EFRFLPPVGY APAYEALLPG RRLFLSPCKT
     YGNLSRGHLM GPGSSWERTV FVPNAVNTQN VILSHYLQNV VPKLESIHEL WAMNRIRGGW
     SYGTVRDEAK KQNPCLVEFA RLPEQERSFN LTMSYETLRT IIALGYHVGI ADEEAEHGLR
     KLKLPRSYIM ASGYKPSPLD LSHVKLTNQM EDLVEKLADN AHNVWARERV KQGWTYGVNL
     DVGKKRNPRL VPFQLLDELA KQSNRNSIRE LVRTLIGHGY MIEPPDDRLK DKTTRIKNPV
     QNNKVRIFRA EKTHSVCAGK WYFEFTIETQ GVMKVGWVDP DCLPSVDLGS NHQAYVFDGV
     NALKLNDGSE TFGQRWKPGD VVGCLLDFSE RKIFFSLNGE LLVDRCGHET AFRNLPSDLT
     LVPAVSLSVD QRGTLNLGKD PDSFQFYSTV GQKEGYQPFA AGMRCGVAMW FTKNLPSFCN
     LDPVHGNIEV KRLSASHHKP PRLKVMYKLI GGSRSHDHQE WVYTRLNLPV STDAVFTKRL
     VIPGHAINIF TENDSVTEDI DSDFEVLRKT ARGGVSSISH HDLKNERHHH HINSLPIPGL
     KGSKFHFSRT KTSNAHVGSN QANQSKPRLA EEVLPDHYNE LMRSTQYSFS VRIFPEQDLG
     SLYVGWVTSD FHWNVDNFQR GLIPTVTITL GDNKGKISER YLRSNCFVLC CGDLPQQAMP
     PNQSSPGIVV TCIIDTATGL LTFAANGSDL NTFFQVEPNV ELYPAVIALP TAHNIFQYEL
     GRTKHIMPLS AAVLKCERKN VVPQCPPRLQ VQTLEQVSWT RMPGRLPRPE CRRDMDRTKG
     WTSESKSSDS DAYNVVVVHI PEENRCIDLL ELGENADLLR FHERTLKLYS SMCALGNHRV
     AHALCSYIDE KQLMRIIRTE GLVGSVRAAY HDLLIEMHLS PHANARRNTQ HEYMFPLNDN
     TQSIGLFSDP ASKRPMVPGV GPSSSIRPTL HWSPINVVMH LIHDVPLEVP EFPLDELRQN
     VIGQLHEAIR ACYRKCKDST GKNQEYLLVP PLRLALTLLT MGVFNDEDIT KLLILLAPSF
     IRTLVEDESL SDLIEDSHCG LLGLQLVESV KLEACLLLEH LMELVLRHRV EALVSFSCVI
     VEELQQDQKS RYQGVMEAIN MSAAMTAKMT REFRSPPLEQ MAILLKFKSE ELEENCPLPQ
     HIKDLLWNFH TDMLLDCGEQ IEEEPVEEDN QDTLRSKLSS IVSRILHKRK EEEESPEESS
     HATVGGGSFR DLIISTMMGW ARGPSINNPQ LVRAIFRLLY RQYNGVGEMQ NALMKTYCIS
     AASEGDTMAL LESLSRLRSL LSVQLGQDEE TLIIKGLNSI MNNKVFYQHP NLMRILCMHE
     TVMEVMVSVL DGDGDSDSIV KFPRMVAACC RFLCYFCRIS RLNQGAMFEH LGFLLEHSSV
     GLATPSMRGS TPLDVAAASV MDNNELALAL KESDLAKLVE QLATCGVESS QLLLRKGYPD
     IGWNPVEGER YLDFLKNAVF VNGESVEENA NLVVRQLIRQ TECLGPSLRG EGGHGLLAAI
     TSALQICRDR SRDGPDLNLC NEYDNDDDIH MGFSILAFYS TLIDLLGRCA PEKYLIMQGK
     SDAIRIRSIL RSLVPREDLI GVISLPFDLP RFERGSTNIR EPDLSACFIP DHKASMVLFL
     ERVYGIDSPH LLLRLLESGL LPDMKSAAQL DVPHINSTDM ALALNRYMCH SVLPLLVKHV
     SLLAHCQHRP QLLDQLLHTI YRMSQAQALT KAQKEMISEC LVAVASVLQP SLLQGLLRKL
     TFDVPALTEE TYIPLQLLKE HYSRCWKYYY LLEGCPDFGV ATDEEKHITM VLFWGIFDSL
     VKKPYSQELF SKVLPCLCSI GNALPPDYAL SPALEKLHQQ SSIDSHGKFH PQPVDTKSIL
     FPEKLDVFVN KCSEQWHDTW ALERFTLGWS YEAHYNEALK QHPMLKPYRL LNDREKDVYR
     PSVREGIKAL IAWGWSFKKI VEATDISQLP AKVRCSSQSN ITASDAHGYL PRPYDLSGVS
     LGREMMRTAE MLAENFHLVW ARKKMGELES KHTNLPSHPM LVPYDRLTAK EKERDRGKAY
     DLLKFFQFNN YVMSKAEKEE VDVKSSVEKR FSSMVLQRLL SYVQQRQQEH AAFGGNYEPP
     SLQQPQANDD IKFFAKVAMP LMESYFKNQE IYYVEACGNA NDGIACRKPN AFILSRLFCK
     MALLIRQRIT MFGVDAGTAI NCVKILAECI DASTITKACS ESMKQALISF FNNAADDLKL
     MLNHIRSGRI KILQTMVAGA HTSNYVSHCL LPLLTILFRH LGRHNFGGEL LLDEIQVSCY
     KILNGLYSLG TGKSAFIDRH RAQVGECLAA FASAFPVSFL EPKLNKFNSY SIYNILSIKD
     RKALGLPPNL EQLTPHLPIL ETLLADINHL ADSGAKYEEA PEMIDIILPL ICSYLPPWLK
     QGPDDNSAVS TGFSSSVSSK VLDVVLRDVL RLIHNNLGTD EADWMRRIAV YTQPIMVRSD
     PDLLADHFLP MIIKLSKRIE QARDLEEQVK YDQRVNDVSD LELLMLEDYG IISRDLYAFY
     PLMVRYIDLS KSCWIRERNP IALQLFRIIS KIMIIWSKSI NFRREEQNFV VQNEIDNMSV
     LTADKSATPS KHCSLQASQR VVKRRGDRYS PSTSLVVACL KRMMPVAINT GHVADFQLLQ
     EAKSRFVQRD TEDDIREYLV QVLNVSDTTW RPQLNCFVRL HSFMSFQSEG TSTNESQDKV
     ESRADWLLEI ARAQHYLFMV DHPPKSRRAV WKKLMSKQRK RAVVSCFRMV PLYNLPKHKV
     ISMFIPSYAQ HWVAADQTKF AGVLIKAVNK PSVEGESGGS DPLQQLISVF SISAITSLIH
     RAIEDDDLYL SYAELMAESC HTGDDDDEEE EKSFEEKEKE KQRLLYEQKR LATRGVAEMV
     LYMISASGGE VSDTVLSTLQ LGIALLTGGN VLVQKTMLAH LQAKKDVRFF TSLAGLMQQC
     SVLDLNAYER CLKSESLGHA SEGTVTETMG DAELTCALFR FLQLLCEGHN GDFQNYLRSQ
     VGNNTTVNII ISTVDYLLRL QEAITDFYWY YSAKDTIDAP GRENFSKAIE VAKQVFNSLT
     EYIQGPCEGN QQALAHSRLW DAVVGFLHVF AHMQMKLAQD STRQLSLLKE LLDLQQDMIV
     MLLSMLEGNV VNGTIGKQLV DTLIESSHNV GLILKFFNMF LRLKDITESE KFTEYDPEHN
     GVVSRRDFHK AMEASKVYSR EEIDFLLRCA VTTDDDKLNY MDFTEQFHGP AADIGFNMAV
     LLTNLSEHMP HDTRLGKFLE MAEAMLEYFQ PNLGRIEIVG GARRIERVYF NIRPSSLEQW
     QKPQVQESKR QFFFDVINDE GEGGRMEEFV NFCEDTIFEM QLASQISETG FGSSSTGPTN
     DDKQCESGSR WVFVASDDFT PHINMKSIKH QAKRLWGMTW MELLKTFFFF LLASSFQLFQ
     YGIDTLRYLW SLMFIVFFSN KLVVALKSKR VSEVVGEMPS PTQHGVEDGV LDEDASDASD
     PLKSDRDDLI VDVFGMDIKQ DSGTLRINNQ NAIFPQLSSH YSEHPDAQEA STLSRTMSFD
     MTTADDSSCT PWQSCMSACG RPARYKQQEI VEDKNAAYLD CLNSFCMGTL ETFKSTSHSQ
     GLFARNFYNF KILALIITFI INFFLLFYKV SGCDKSYWQS INEDLDVDES ERLVLVDTTL
     YMEPALKIFR AIHFILSFSM LVSYYGLKVP LVIFKREKEI ARKLEFGGLY VSEDPSDDDL
     SGRWDRLVVS APSFPSNYWD KFIKKKVLDK FGEQCGVERI RELLGMSESS TSFVEDEEPI
     KGNIITQLLL KVDLKYTIWK VGVVFCDQSF LYLLWYFTMS IFGQYNHFFF SLHLLDIAAC
     SKGLRTILTS VTHNGKQLVL TIGLLTVVVY LYTVVAFNFF KKFYNKGEND EDDWKCNSMF
     TCFQFHFYSG VRAGGGIGDE LDDPSGDAWE FYRIAFDISF FFFVIVILLA IIQGLIIDAF
     GELRDQQEQV KEDMDTKCFI CTIGIDYFDQ VPHGFESHTM QEHNLANYMF FLMHLINKDE
     TEHTGQETYV WQQYQERCWE FFPAGDCFRK QYENELS
//
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