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Database: UniProt
Entry: H2Y880_CIOSA
LinkDB: H2Y880_CIOSA
Original site: H2Y880_CIOSA 
ID   H2Y880_CIOSA            Unreviewed;      4877 AA.
AC   H2Y880;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   10-MAY-2017, entry version 32.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001528};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001528, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001528}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001528}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001528}.
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DR   Ensembl; ENSCSAVT00000001548; ENSCSAVP00000001528; ENSCSAVG00000000873.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4251   4269       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4427   4448       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4488   4507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4617   4636       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4679   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4754   4777       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    165       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    281       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      287    337       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      352    409       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      595    810       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1029   1222       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4877 AA;  552333 MW;  6601A160F53B651E CRC64;
     VTMDGDGDEE VHFLRTEDEI YLQCVTQKDH QGKLCLAAEG FGNRLCYVEQ SHEDKDSRPT
     DAPRCVFVLA QALSVRALQE LLAKDEVKEA QQSIVSGEDQ ARREDGSTHS RTLLYGNAVQ
     LKHGLSAMYL TCLTTASSSC DKLAFDVGIS EDQSGEASWW TVHPTSKQRS EGEKVRIGDD
     LILISIASER YLHLSCGDPG GVNVEASFQH SMWTVAPIAS GGSKVEGYLT GGDVIRLFHG
     HMDDCLTVDS AEEMKSHTRP IVYESGRAGS HARSLWRLEL LQIKWFGSHV AWGIPFRLRH
     ITSGLYLSVM DDQSLGLTSP EGATYRTAVF CWQASKDRPE SKADHEIDGM GAPEIKYGDS
     VCYLQHVDSG LWMTYQTIDT KSGRCGPKQR MAVLHDDGRM DDGFMLSRAH PGEARTATII
     RRTTEIFCNF INALDSHQNK KMSRRPEQPN VEEVEQCVDD LIEYFQEGRG EEGGHEVHQH
     IVQELKNRQD LFQEEDAVSH VLQCIDKLAV YGDAGNFAQI VGVEASASYE SLLNSMYVLL
     AATVRGNRNN CSKFAPHLDW LVGQLDGQQA AMGILEVLAA VLEDSQEALN MMKQDHIRSI
     ISLLEKQCRN PKVLEVLSSL CVCNGVAVRG NQNLICETLL PGRDLLLQTA LQSYITNVQP
     NIYMGVSNAC AQYKKWYYEV IVEAVDRSTF AGHLRVGWAN TEGFSPYPVG GDYYGENGVG
     DDMHSFGFDG INLWTSHRAC PVGSNNRHIL APNDIISCCM DLSIPTISFR INGQPVQGMF
     EDFNLNGLFF PVVSFSPGVK VRFLFGGPHG EFRFLPPVGY APAYEALLPG RRLFLSPCKT
     YGNLSRGHLM GPGSSWERTV FVPNAVNTQN VILSHYLQNV VPKLESIHEL WAMNRIRGGW
     SYGTVRDEAK KQNPCLVEFA RLPEQERSFN LTMSYETLRT IIALGYHVGI ADEEAEHGLR
     KLKLPRSYIM ASGYKPSPLD LSHVKLTNQM EDLVEKLADN AHNVWARERV KQGWTYGVNL
     DVGKKRNPRL VPFQLLDELA KQSNRNSIRE LVRTLIGHGY MIEPPDDRLK DKTTRIKNPV
     QNNKVRIFRA EKTHSVCAGK WYFEFTIETQ GVMKVGWVDP DCLPSVDLGS NHQAYVFDGV
     NALKLNDGSE TFGQRWKPGD VVGCLLDFSE RKIFFSLNGE LLVDRCGHET AFRNLPSDLT
     LVPAVSLSVD QRGTLNLGKD PDSFQFYSTV GQKEGYQPFA AGMRCGVAMW FTKNLPSFCN
     LDPVHGNIEV KRLSASHHKP PRLKVMYKLI GGSRSHDHQE WVYTRLNLPV STDAVFTKRL
     VIPGHAINIF TENDSVTEDI DSDFEVLRKT ARGGVSSISH HDLKNERHHH HINSLPIPDN
     QRRPYLVNKV KPGHKPRLAE EVLPDHYNEL MRSTQYSFSV RIFPEQDLGS LYVGWVTSDF
     HWNVDNFQRG LIPTVTITLG DNKGKISERY LRSNCFVLCC GDLPQQAMPP NQSSPGIVVT
     CIIDTATGLL TFAANGSDLN TFFQVEPNVE LYPAVIALPT AHNIFQYELG RTKHIMPLSA
     AVLKCERKNV VPQCPPRLQV QTLEQVSWTR MPGRLPRPEC RRDMDRTKGW TSESKSSDSD
     AYNVVVVHIP EENRCIDLLE LGENADLLRF HERTLKLYSS MCALGNHRVA HALCSYIDEK
     QLMRIIRTEG LVGSVRAAYH DLLIEMHLSP HANARRNTQH EYMFPLNDNT QSIGLFSDPA
     SKRPMVPGVG PSSSIRPTLH WSPINVVMHL IHDVPLEVPE FPLDELRQNV IGQLHEAIRA
     CYRKCKDSTG KNQEYLLVPP LRLALTLLTM GVFNDEDITK LLILLAPSFI RTLVEDENLI
     EDSHCGLLGL QLVESVKLEA CLLLEHLMEL VLRHRVEALV SFSCVIVEEL QQDQKSRYQG
     VMEAINMSAA MTAKMTREFR SPPLEQMAIL LKFKSEELEE NCPLPQHIKD LLWNFHTDML
     LDCGEQIEEE PVEEDNQDTL RSKLSSIVSR ILHKRKEEEE SPEESSHATV GGGSFRDLII
     STMMGWARGP SINNPQLVRA IFRLLYRQYN GVGEMQNALM KTYCISAASE GDTMALLESL
     SRLRSLLSVQ LGQDEETLII KGLNSIMNNK VFYQHPNLMR ILCMHETVME VMVSVLDGDG
     DSDSIVKFPR MVAACCRFLC YFCRISRLNQ GAMFEHLGFL LEHSSVGLAT PSMRGSTPLD
     VAAASVMDNN ELALALKESD LAKVNLAQLA TCGVESSQLL LRKGYPDIGW NPVEGERYLD
     FLKNAVFVNG ESVEENANLV VRQLIRQTEC LGPSLRGEGG HGLLAAITSA LQICRDRSRD
     GPDLNLCNEY DNDDDIHMGF SILAFYSTLI DLLGRCAPEK YLIMQGKSDA IRIRSILRSL
     VPREDLIGVI SLPFDLPRFE RGSTNIREPD LSACFIPDHK ASMVLFLERV YGIDSPHLLL
     RLLESGLLPD MKSAAQLDVP HINSTDMALA LNRYMCHSVL PLLVKHVSLL AHCQHRPQLL
     DQLLHTIYRM SQAQALTKAQ KEMISECLVA VASVLQPSLL QGLLRKLTFD VPALTEETYI
     PLQLLKEHYS RCWKYYYLLE GCPDFGVATD EEKHITMVLF WGIFDSLVKK PYSQELFSKV
     LPCLCSIGNA LPPDYALSPA LEKLHQQSSI DSHGKFHPQP VDTKSILFPE KLDVFVNKCS
     EQWHDTWALE RFTLGWSYEA HYNEALKQHP MLKPYRLLND REKDVYRPSV REGIKALIAW
     GWSFKKIVEA TDISQLPAKV RCSSQSNITA SDAHGYLPRP YDLSGVSLGR EMMRTAEMLA
     ENFHLVWARK KMGELESKHT NLPSHPMLVP YDRLTAKEKE RDRGKAYDLL KFFQFNNYVM
     SKAEKEEVDV KSSVEKRFSS MVLQRLLSYV QQRQQEHAAF GGNYEPPSLQ QPQANDDIKF
     FAKVAMPLME SYFKNQEIYY VEACGNANDG IACRKPNAFI LSRLFCKMAL LIRQRITMFG
     VDAGTAINCV KILAECIDAS TITKACSESM KQALISFFNN AADDLKLMLN HIRSGRIKIL
     QTMVAGAHTS NYVSHCLLPL LTILFRHLGR HNFGGELLLD EIQVSCYKIL NGLYSLGTGK
     SAFIDRHRAQ VGECLAAFAS AFPVSFLEPK LNKFNSYSIY NILSIKDRKA LGLPPNLEQL
     TPHLPILETL LADINHLADS GAKYEEAPEM IDIILPLICS YLPPWLKQGP DDNSAVSTGF
     SSSVSSKVLD VVLRDVLRLI HNNLGTDEAD WMRRIAVYTQ PIMVRSDPDL LADHFLPMII
     KLSKRIEQAR DLEEQVKYDQ RVNDVSDLEL LMLEDYGIIS RDLYAFYPLM VRYIDLSKSC
     WIRERNPIAL QLFRIISKIM IIWSKSINFR REEQNFVVQN EIDNMSVLTA DKSATPSKHC
     SLQASQRVVK RRGDRYSPST SLVVACLKRM MPVAINTGHV ADFQLLQEAK SRFVQRDTED
     DIREYLVQVL NVSDTTWRPQ LNCFVRLHSF MSFQSEGTST NESQDKVESR ADWLLEIARA
     QHYLFMVDHP PKSRRAVWKK LMSKQRKRAV VSCFRMVPLY NLPKHKVISM FIPSYAQHWV
     AADQTKFAGV LIKAVNKPSV EGESGGSDPL QQLISVFSIS AITSLIHRAI EDDDLYLSYA
     ELMAESCHTG DDDDEEEEKS FEEKEKEKQR LLYEQKRLAT RGVAEMVLYM ISASGGEVSD
     TVLSTLQLGI ALLTGGNVLV QKTMLAHLQA KKDVRFFTSL AGLMQQCSVL DLNAYERCLK
     SESLGHASEG TVTETMGDAE LTCALFRFLQ LLCEGHNGDF QNYLRSQVGN NTTVNIIIST
     VDYLLRLQEA ITDFYWYYSA KDTIDAPGRE NFSKAIEVAK QVFNSLTEYI QGPCEGNQQA
     LAHSRLWDAV VGFLHVFAHM QMKLAQDSTR QLSLLKELLD LQQDMIVMLL SMLEGNVVNG
     TIGKQLVDTL IESSHNVGLI LKFFNMFLRL KDITESEKFT EYDPEHNGVV SRRDFHKAME
     ASKVYSREEI DFLLRCAVTT DDDKLNYMDF TEQFHGPAAD IGFNMAVLLT NLSEHMPHDT
     RLGKFLEMAE AMLEYFQPNL GRIEIVGGAR RIERVYFNIR PSSLEQWQKP QVQESKRQFF
     FDVINDEGEG GRMEEFVNFC EDTIFEMQLA SQISETGFGS SSTGPTNDDV DDEDVETISD
     DFTPHINMKS IKHQAKRLWG MTWMELLKTF FFFLLASSFQ LFQYGIDTLR YLWSLMFIVF
     FSNKLVVALK SKRVSEVVGE MPSPTQHGVE DGVLDEDASD ASDPLKSDRD DLIVDVFGMD
     IKKETRSNIK HNQLACELMN NAIFPQLSSH YSEHPDAQEA STLSRTMSFD MTTADDSSCT
     PWQSCMSACG RPARYKQQEI VEDKNAAYLD CLNSFCMGTL GLFARNFYNF KILALIITFI
     INFFLLFYKV SGCDKSYVIN INEDLDVDES ERLVLVDTTL YMEPALKIFR AIHFILSFSM
     LVSYYGLKVP LVIFKREKEI ARKLEFGGLY VSEDPSDDDL SGRWDRLVVS APSFPSNYWD
     KFIKKKVLDK FGEQCGVERI RELLGMSESS TSFVEDEEPI KGNIITQLLL KVDLKYTIWK
     VGVVFCDQSF LYLLWYFTMS IFGQYNHFFF SLHLLDIAAC SKGLRTILTS VTHNGKQLVL
     TIGLLTVVVY LYTVVAFNFF KKFYNKGEND EDDWKCNSMF TCFQFHFYSG VRAGGGIGDE
     LDDPSGDAWE FYRIAFDISF FFFVIVILLA IIQGLIIDAF GELRDQQEQV KEDMDTKCFI
     CTIGIDYFDQ VPHGFESHTM QEHNLANYMF FLMHLINKDE TEHTGQETYV WQQYQERCWE
     FFPAGDCFRK QYENELS
//
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