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Database: UniProt
Entry: H2Y881_CIOSA
LinkDB: H2Y881_CIOSA
Original site: H2Y881_CIOSA 
ID   H2Y881_CIOSA            Unreviewed;      4811 AA.
AC   H2Y881;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001529};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001529, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001529}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001529}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001529}.
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DR   Ensembl; ENSCSAVT00000001549; ENSCSAVP00000001529; ENSCSAVG00000000873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 5.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4160   4179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4362   4383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4423   4442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4552   4571       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4614   4634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4688   4711       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       94    149       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      156    202       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      210    265       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      271    321       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      336    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      579    794       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1013   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4811 AA;  544252 MW;  9A8A14CAD3983024 CRC64;
     VTMDGDGDEE VHFLRTEDEI YLQCVTQKDH QGKLCLAAEG FGNRLCYVEQ SHEDKDSRPT
     DAPRCVFVLA QALSVRALQE LLAKDEVKDG STHSRTLLYG NAVQLKHGLS AMYLTCLTTA
     SSSCDKLAFD VGISEDQSGE ASWWTVHPTS KQRSEGEKVR IGDDLILISI ASERYLHLSC
     GDPGGVNVEA SFQHSMWTVA PIASGGSKVE GYLTGGDVIR LFHGHMDDCL TVDSAEEMKS
     HTRPIVYESG RAGSHARSLW RLELLQIKWF GSHVAWGIPF RLRHITSGLY LSVMDDQSLG
     LTSPEGATYR TAVFCWQASK DRPESKADHE IDGMGAPEIK YGDSVCYLQH VDSGLWMTYQ
     TIDTKSGRCG PKQRMAVLHD DGRMDDGFML SRAHPGEART ATIIRRTTEI FCNFINALDS
     HQNKKMSRRP EQPNVEEVEQ CVDDLIEYFQ EGRGEEGGHE VHQHIVQELK NRQDLFQEED
     AVSHVLQCID KLAVYGDAGN FAQIVGVEAS ASYESLLNSM YVLLAATVRG NRNNCSKFAP
     HLDWLVGQLD GQQAAMGILE VLAAVLEDSQ EALNMMKQDH IRSIISLLEK QCRNPKVLEV
     LSSLCVCNGV AVRGNQNLIC ETLLPGRDLL LQTALQSYIT NVQPNIYMGV SNACAQYKKW
     YYEVIVEAVD RSTFAGHLRV GWANTEGFSP YPVGGDYYGE NGVGDDMHSF GFDGINLWTS
     HRACPVGSNN RHILAPNDII SCCMDLSIPT ISFRINGQPV QGMFEDFNLN GLFFPVVSFS
     PGVKVRFLFG GPHGEFRFLP PVGYAPAYEA LLPGRRLFLS PCKTYGNLSR GHLMGPGSSW
     ERTVFVPNAV NTQNVILSHY LQNVVPKLES IHELWAMNRI RGGWSYGTVR DEAKKQNPCL
     VEFARLPEQE RSFNLTMSYE TLRTIIALGY HVGIADEEAE HGLRKLKLPR SYIMASGYKP
     SPLDLSHVKL TNQMEDLVEK LADNAHNVWA RERVKQGWTY GVNLDVGKKR NPRLVPFQLL
     DELAKQSNRN SIRELVRTLI GHGYMIEPPD DRLKDKTTRI KNPVQNNKVR IFRAEKTHSV
     CAGKWYFEFT IETQGVMKVG WVDPDCLPSV DLGSNHQAYV FDGVNALKLN DGSETFGQRW
     KPGDVVGCLL DFSERKIFFS LNGELLVDRC GHETAFRNLP SDLTLVPAVS LSVDQRGTLN
     LGKDPDSFQF YSTVGQKEGY QPFAAGMRCG VAMWFTKNLP SFCNLDPVHG NIEVKRLSAS
     HHKPPRLKVM YKLIGGSRSH DHQEWVYTRL NLPVSTDATS NAHVGSNQAN QSKPRLAEEL
     MRSTQYSFSV RIFPEQDLGS LYVGWVTSDF HWNVDNFQRG LIPTVTITLG DNKGKISERY
     LRSNCFVLCC GDLPQQAMPP NQSSPGIVVT CIIDTATGLL TFAANGSDLN TFFQVEPNVE
     LYPAVIALPT AHNIFQYELG RTKHIMPLSA AVLKCERKNV VPQCPPRLQV QTLEQVSWTR
     MPGRLPRPEC RRDMDRTKGW TSESKSSDSD AYNVVVVHIP EENRCIDLLE LGENADLLRF
     HERTLKLYSS MCALGNHRVA HALCSYIDEK QLMRIIRTEG LVGSVRAAYH DLLIEMHLSP
     HANARRNTQH EYMFPLNDNT QSIGLFSDPA SKRPMVPGVG PSSSIRPTLH WSPINVVMHL
     IHDVPLEVPE FPLDELRQNV IGQLHEAIRA CYRKCKDSTG KNQEYLLVPP LRLALTLLTM
     GVFNDEDITK LLILLAPSFI RTLVEDESLS DLIEDSHCGL LGLQLVESVK LEACLLLEHL
     MELVLRHRVE ALVSFSCVIV EELQQDQKSR YQGVMEAINM SAAMTAKMTR EFRSPPLEQM
     AILLNEELEE NCPLPQHIKD LLWNFHTDML LDCGEQIEEE PVEEDNQDTL RSKLSSIVSR
     ILHKRKEEEE SPEESSHATV GGGSFRDLII STMMGWARGP SINNPQLVRA IFRLLYRQYN
     GVGEMQNALM KTYCISAASE GDTMALLESL SRLRSLLSVQ LGQDEETLII KGLNSIMNNK
     VFYQHPNLMR ILCMHETVME VMVSVLDGDG DSDSIVKFPR MVAACCRFLC YFCRISRLNQ
     GAMFEHLGFL LEHSSVGLAT PSMRGSTPLD VAAASVMDNN ELALALKESD LAKLVEQLAT
     CGVESSQLLL RKGYPDIGWN PVEGERYLDF LKNAVFVNGE SVEENANLVV RQLIRQTECL
     GPSLRGEGGH GLLAAITSAL QICRDRSRDG PDLNLCNEYD NDDDIHMGFS ILAFYSTLID
     LLGRCAPEKY LIMQGKSDAI RIRSILRSLV PREDLIGVIS LPFDLPRFER EGSTNIREPD
     LSACFIPDHK ASMVLFLERV YGIDSPHLLL RLLESGLLPD MKSAAQLDVP HINSTDMALA
     LNRYMCHSVL PLLVKHVSLL AHCQHRPQLL DQLLHTIYRM SQAQALTKAQ KEMISECLVA
     VASVLQPSLL QGLLRKLTFD VPALTEETYI PLQLLKEHYS RCWKYYYLLE GCPDFGVATD
     EEKHITMVLF WGIFDSLVKK PYSQELFSKV LPCLCSIGNA LPPDYALSPA LEKLHQQSSI
     DSHGKFHPQP VDTKSILFPE KLDVFVNKCS EQWHDTWALE RFTLGWSYEA HYNEALKQHP
     MLKPYRLLND REKDVYRPSV REGIKALIAW GWSFKKIVEA TDISQLPAKV RCSSQSNITA
     SDAHGYLPRP YDLSGVSLGR EMMRTAEMLA ENFHLVWARK KMGELESKHT NLPSHPMLVP
     YDRLTAKEKE RDRGKAYDLL KFFQFNNYVM SKAEKEEVDV KSSVEKRFSS MVLQRLLSYV
     QQRQQEHAAF GGNYEPPSLQ QPQANDDIKF FAKVAMPLME SYFKNQEIYY VEACGNANDG
     IACRKPNAFI LSRLFCKMAL LIRQRITMFG VDAGTAINCV KILAECIDAS TITKACSESM
     KQALISFFNN AADDLKLMLN HIRSGRIKIL QTMVAGAHTS NYVSHCLLPL LTILFRHLGR
     HNFGGELLLD EIQVSCYKIL NGLYSLGTGK SAFIDRHRAQ VGECLAAFAS AFPVSFLEPK
     LNKFNSYSIY NILSIKDRKA LGLPPNLEQL TPHLPILETL LADINHLADS GAKYEEAPEM
     IDIILPLICS YLPPWLKQGP DDNSAVSTGF SSSVSSKVLD VVLRDVLRLI HNNLGTDEAD
     WMRRIAVYTQ PIMVRSDPDL LADHFLPMII KLSKRIEQAR DLEEQVKYDQ RVNDVSDLEL
     LMLEDYGIIS RDLYAFYPLM VRYIDLSKSC WIRERNPIAL QLFRIISKIM IIWSKSINFR
     REEQNFVVQN EIDNMSVLTA DKSATPSAAS MLVSKHCSLQ ASQRVVKRRG DRYSPSTSLV
     VACLKRMMPV AINTGHVADF QLLQEAKSRF VQRDTEDDIR EYLVQVLNVS DTTWRPQLNC
     FVRLHSFMSF QSEGTSTNES QDKVESRADW LLEIARAQHY LFMVDHPPKS RRAVWKKLMS
     KQRKRAVVSC FRMVPLYNLP KHKVISMFIP SYAQHWVAAD QTKFAGVLIK AVNKPSVEGE
     SGGSDPLQQL ISVFSISAIT SLIHRAIEDD DLYLSYAELM AESCHTGDDD DEEEEKSFEE
     KEKEKQRLLY EQKRLATRGV AEMVLYMISA SGGEVSDTVL STLQLGIALL TGGNVLVQKT
     MLAHLQAKKD VRFFTSLAGL MQQCSVLDLN AYERCLKSES LGHASEGTVT GGETMGDAEL
     TCALFRFLQL LCEGHNGDFQ NYLRSQVGNN TTVNIIISTV DYLLRLQEAI TDFYWYYSAK
     DTIDAPGREN FSKAIEVAKQ VFNSLTEYIQ GPCEGNQQAL AHSRLWDAVV GFLHVFAHMQ
     MKLAQDSTRQ LSLLKELLDL QQDMIVMLLS MLEGNVVNGT IGKQLVDTLI ESSHNVGLIL
     KFFNMFLRLK DITESEKFTE YDPEHNGVVS RRDFHKAMEA SKVYSREEID FLLRCAVTTD
     DDKLNYMDFT EQFHGPAADI GFNMAVLLTN LSEHMPHDTR LGKFLEMAEA MLEYFQPNLG
     RIEIVGGARR IERVYFNIRP SSLEQWQKPQ VQESKRQFFF DVINDEGEGG RMEEFVNFCE
     DTIFEMQLAS QISETGFGSS STGPTNDDVD DEDVETISDD FTPHINMKSI KHQAKRLWGM
     TWMELLKTFF FFLLASSFQL FQYLWSLMFI VFFSNKLVVA LKSKRVSEVV GEMPSPTQHG
     VEDGVLDEDA SDASDPLKSD RDDLIVDVKG KELMKAVVHT KREAGFGDFS VEEAADTLSM
     IASDYDSGFN TPRATRIKKR RKLLRKGRRL DAQEASTLSR TMSFDMTTAD DSSCTPWQSC
     MSACGRPARY KQQEIVEDKN AAYLDCLNSF CMGTLGLFAR NFYNFKILAL IITFIINFFL
     LFYKVSGCDK SYWQSINEDL DVDESERLVL VDTTLYMEPA LKIFRAIHFI LSFSMLVSYY
     GLKVPLVIFK REKEIARKLE FGGLYVSEDP SDDDLSGRWD RLVVSAPSFP SNYWDKFIKK
     KVLDKFGEQC GVERIRELLG MSESSTSFVE DEEPIKGNII TQLLKVDLKY TIWKVGVVFC
     DQSFLYLLWY FTMSIFGQYN HFFFSLHLLD IAACSKGLRT ILTSVTHNGK QLVLTIGLLT
     VVVYLYTVVA FNFFKKFYNK GENDEDDWKC NSMFTCFQFH FYSGVRAGGG IGDELDDPSG
     DAWEFYRIAF DISFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMDT KCFICTIGID
     YFDQVPHGFE SHTMQEHNLA NYMFFLMHLI NKDETEHTGQ ETYVWQQYQE RCWEFFPAGD
     CFRKQYENEL S
//
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