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Database: UniProt
Entry: H2Y884_CIOSA
LinkDB: H2Y884_CIOSA
Original site: H2Y884_CIOSA 
ID   H2Y884_CIOSA            Unreviewed;      5011 AA.
AC   H2Y884;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCSAVP00000001532};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000001532, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000001532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000001532}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000001532}.
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DR   STRING; 51511.ENSCSAVP00000001532; -.
DR   Ensembl; ENSCSAVT00000001552; ENSCSAVP00000001532; ENSCSAVG00000000873.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2Y884; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 7.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4394   4418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4575   4595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4635   4654       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4771       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4814   4834       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4888   4911       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       88    143       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      150    196       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    259       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      265    315       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      573    788       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1007   1200       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   5011 AA;  567904 MW;  C1BBBA7190342F0A CRC64;
     RNMNVTIPSQ EDEIYLQCVT QKDHQGKLCL AAEGFGNRLC YVEQSHEDKD SRPTDAPRCV
     FVLAQALSVR ALQELLAKDE VKDGSTHSRT LLYGNAVQLK HGLSAMYLTC LTTASSSCDK
     LAFDVGISED QSGEASWWTV HPTSKQRSEG EKVRIGDDLI LISIASERYL HLSCGDPGGV
     NVEASFQHSM WTVAPIASGG SKVEGYLTGG DVIRLFHGHM DDCLTVDSAE EMKSHTRPIV
     YESGRAGSHA RSLWRLELLQ IKWFGSHVAW GIPFRLRHIT SGLYLSVMDD QSLGLTSPEG
     ATYRTAVFCW QASKDRPESK ADHEIDGMGA PEIKYGDSVC YLQHVDSGLW MTYQTIDTKS
     GRCGPKQRMA VLHDDGRMDD GFMLSRAHPG EARTATIIRR TTEIFCNFIN ALDSHQNKKM
     SRRPEQPNVE EVEQCVDDLI EYFQEGRGEE GGHEVHQHIV QELKNRQDLF QEEDAVSHVL
     QCIDKLAVYG DAGNFAQIVG VEASASYESL LNSMYVLLAA TVRGNRNNCS KFAPHLDWLV
     GQLDGQQAAM GILEVLAAVL EDSQEALNMM KQDHIRSIIS LLEKQCRNPK VLEVLSSLCV
     CNGVAVRGNQ NLICETLLPG RDLLLQTALQ SYITNVQPNI YMGVSNACAQ YKKWYYEVIV
     EAVDRSTFAG HLRVGWANTE GFSPYPVGGD YYGENGVGDD MHSFGFDGIN LWTSHRACPV
     GSNNRHILAP NDIISCCMDL SIPTISFRIN GQPVQGMFED FNLNGLFFPV VSFSPGVKVR
     FLFGGPHGEF RFLPPVGYAP AYEALLPGRR LFLSPCKTYG NLSRGHLMGP GSSWERTVFV
     PNAVNTQNVI LSHYLQNVPN WTESIHELWA MNRIRGGWSY GTVRDEAKKQ NPCLVEFARL
     PEQERSFNLT MSYETLRTII ALGYHVGIAD EEAEHGLRKL KLPRSYIMAS GYKPSPLDLS
     HVKLTNQMED LVEKLADNAH NVWARERVKQ GWTYGVNLDV GKKRNPRLVP FQLLDELAKQ
     SNRNSIRELV RTLIGHGYMI EPPDDRLKDK TTRIKNPVQN NKVRIFRAEK THSVCAGKWY
     FEFTIETQGV MKVGWVDPDC LPSVDLGSNH QAYVFDGVNA LKLNDGSETF GQRWKPGDVV
     GCLLDFSERK IFFSLNGELL VDRCGHETAF RNLPSDLTLV PAVSLSVDQR GTLNLGKDPD
     SFQFYSTVGQ KEGYQPFAAG MRCGVAMWFT KNLPSFCNLD PVHGNIEVKR LSASHHKPPR
     LKVMYKLIGG SRSHDHQEWV YTRLNLPVST DAVFTKRLMR YTNLMFAQIS TAISRFCGRL
     REEASPPSPI MTSRTNVIII TSTPCPSQVT HHPNTPSPHI PLTPTQPPTP IPTPHTHPNA
     SVSRYMKVFR LKRCLTHTWS STPPVWGDQD NQRRPYLVNK VKPGSKFHFS RTKTSNAHVG
     SNQANQSKPR LAEEVLPDHY NEVLYKNDID QVYFKHKCET DLNQSHHRSI IIIDVCTLRI
     FYVPLMRSTQ YSFSVRIFPE QDLGSLYVGW VTSDFHWNVD NFQRGLIPTV TITLGDNKGK
     ISERYLRSNC FVLCCGDLPQ QAMPPNQSSP GIVVTCIIDT ATGLLTFAAN GSDLNTFFQV
     EPNVELYPAV IALPTAHNIF QYELGRTKHI MPLSAAVLKC ERKNVVPQCP PRLQVQTLEQ
     VSWTRMPGRL PRPECRRDMD RTKGWTSESK SSDSDAYNVV VVHIPEENRC IDLLELGENA
     DLLRFHERTL KLYSSMCALG NHRVAHALCS YIDEKQLMRI IRTEGLVGSV RAAYHDLLIE
     MHLSPHANAR RNTQHEYMFP LNDNTHLIHD VPLEVPEFPL DELRQNVIGQ LHEAIRACYR
     KCKDSTGKNQ EYLLVPPLRL ALTLLTMGVF NDEDITKLLI LLAPSFIRTL VEDENSHCGL
     LGLQLVESVK LEACLLLEHL MELVLRHRVE ALVSFSCVIV EELQQDQKSR YQGVMEAINM
     SAAMTAKMTR EFRSPPLEQM AILLKFKSEE LEENCPLPQH IKDLLWNFHT DMLLDCGEQI
     EEEPVEEDNQ DTLRSKLSSI VSRILHKRKE EEESPEESSH ATVGGGSFRD LIISTMMGWA
     RGPSINNPQL VRAIFRLLYR QYNGVGEMQN ALMKTYCISA ASEGDTMALL ESLSRLRSLL
     SVQLGQDEET LIIKGLNSIM NNKVFYQHPN LMRILCMHET VMEVMVSVLD GDGDSDSIEV
     KFPRMVAACC RFLCYFCRIS RLNQGAMFEH LGFLLEHSSV GLATPSMRGS TPLDVAAASV
     MDNNELALAL KESDLAKVNL ALATCGVESS QLLLRKGYPD IGWNPVEGER YLDFLKNAVF
     VNGESVEENA NLVVRQLIRQ TECLGPSLRG EGGHGLLAAI TSALQICRDR SRDGPDLNFN
     EYDNDDDIHM GFSILAFYST LIDLLGRCAP EKYLIMQGKS DAIRIRSILR SLVPREDLIG
     VISLPFDLPR FERVRYTNIV FPPPPLNVIP HFPPTIHRRI KEKMYKLNVK SDLGIKRCIK
     ALLKVIKWCM LKVKGSTNIR EPDLSACFIP DHKASMVLFL ERVYGIDSPH LLLRLLESGL
     LPDMKSAAQL DVPHINSTDM ALALNRYMCH SVLPLLVKHV SLLAHCQHRP QLLDQLLHTI
     YRMSQAQALT KAQKEMISEC LVAVASVLQP SLLQGLLRKL TFDVPALTEE TYIPLQLLKE
     HYSRCWKYYY LLEGCPDFGV ATDEEKHITM VLFWGIFDSL VKKPYSQELF SKVLPCLCSI
     GNALPPDYAL SPALEKLHQQ SSIDSHGKFH PQPVDTKSIL FPEKLDVFVN KCSEQWHDTW
     ALERFTLGWS YEAHYNEALK QHPMLKPYRL LNDREKDVYR PSVREGIKAL IAWGWSFKKI
     VEATDISQLP AKVRCSSQSN ITASDAHGYL PRPYDLSGVS LGREMMRTAE MLAENFHLVW
     ARKKMGELES KHTNLPSHPM LVPYDRLTAK EKERDRGKAY DLLKFFQFNN YVMSKAEKEE
     VDVKSSVEKR FSSMVLQRLL SYVQQVSYVQ QVSYVQWVSY VQHVSYPQAN DDIKFFAKVA
     MPLMESYFKN QEIYYVEACG NANDGIACRK PNAFILSRLF CKMALLIRQR ITMFGVDAGT
     AINCVKILAE CIDASTITKA CSESMKQALI SFFNNAADDL KLMLNHIRSG RIKILQTMVA
     GAHTSNYVSH CLLPLLTILF RHLGRHNFGG ELLLDEIQVS CYKILNGLYS LGTGKSVSTI
     IIVYNYSPSH RAQVGECLAA FASAFPVSFL EPKLNKFNSY SIYNILSIKD RKALGLPPNL
     EQLTPHLPIL ETLLADINHL ADSGAKYEEA PEMIDIILPL ICSYLPPWLK QGPDDNSAVS
     TGFSSSVSSK VLDVVLRDVL RLIHNNLGTD EADWMRRIAV YTQPIMVRSD PDLLADHFLP
     MIIKLSKRIE QARDLEEQVM NDVSDLELLM LEDYGIISRD LYAFYPLMVR YIDLSKSCWI
     RERNPIALQL FRIISKIMII WSKSINFRRE EQNFVVQNEI DNMSVLTADK SATPSAASML
     VSKHCSLQAS QRVVKRRGDR YSPSTSLVVA CLKRMMPVAI NTGHVADFQL LQEAKSRFVQ
     RDTEDDIREY LVQVLNVSCL SFQEVSDTTW RPQLNCFVRL HSFMSFQSEG TSTNESQDKV
     ESRADWLLEI ARAQHYLFMV DHPPKSRRAV WKKLMSKQRK RAVVSCFRMV PLYNLPKHRV
     SNCFLSNYME KWLNSEDQDK CGLIEIITVY CTLVPLCATC LLGLPAPLLL DRIVEGESGG
     SDPLQQLISV FSISAITSLI HRAIEDDDLY LSYAELMAES CHTGDDDDEE EEKSFEEKEK
     EKQRLLYEQK RLATRGVAEM VLYMISASGG EVSDTVLSTL QLGIALLTGG NVLVQKTMLA
     HLQAKKDVRF FTSLAGLMQQ CSVLDLNAYE RCLKSESLGH ASEGTVTGGE TMGDAELTCA
     LFRFLQLLCE GHNGDFQNYL RSQVGNNTTV NIIISTVDYL LRLQEAITDF YWYYSAKDTI
     DAPGRENFSK AIEVAKQVFN SLTEYIQGPC EGNQQALAHS RLWDAVVGFL HVFAHMQMKL
     AQDSTRQLSL LKELLDLQQD MIVMLLSMLE GNVVNGTIGK QLVDTLIESS HNVGLILKFF
     NMFLRLKDIT ESEKFTEYDP EHNGVVSRRD FHKAMEASKV YSREEIDFLL RCAVTTDDDK
     LNYMDFTEQF HGPAADIGFN MAVLLTNLSE HMPHDTRLGK FLEMAEAMLE YFQPNLGRIE
     IVGGARRIER VYFNIRPSSL EQWQKPQVQE SKRQFFFDVI NDEGEGGRME EFVNFCEDTI
     FEVDATCITD NPSPSQITLV YRSNHIPPQM QLASQISETG FGSSSTGPTN DDVDDEDVET
     MLWGMTWMEL LKTFFFFLLA SSFQLFQYLW SLMFIVFFSN KLVVALKSKR VSEVVGEMPS
     PTQHGVEDGV LDEDASDASD PLKSDRDDLI AGFGDFSVEE AADTLSMIAS DYDSGFNTPR
     ATRIKKRRKL LRKGRRLGQT SSTTSSLVIC IKCATILKLP NMCDWQMDGF ELHLTANETF
     KSTSHSQGLF ARNFYNFKIL ALIITFIINF FLLFYKVSGC DKSYWQSINE DLDVDESERL
     VLVDTTLYME PALKIFRAIH FILSFSMLVS YYGLKVPLVI FKREKEIARK LEFGGLYVSE
     DPSDDDLSGR WDRLVVSAPS FPSNYWDKFI KKKVLDKFGE QCGVERIREL LGMSESSTSF
     ATSSHMDLKY TIWKVGVVFC DQSFLYLLWY FTMSIFGQYN HFFFSLHLLD IAACSKGLRT
     ILTSVTHNGK QLVLTIGLLT VVVYLYTVVA FNFFKKFYNK GENDEDDWKC NSMFTCFQFH
     FYSGVRAGGG IGDELDDPSG DAWEFYRIAF DISFFFFVIV ILLAIIQGLI IDAFGELRDQ
     QEQVKEDMDT KCFICTIGID YFDQVPHGFE SHTMQEHNLA NYMFFLMHLI NKDETEHTGQ
     ETYVWQQYQE RCWEFFPAGD CFRKQYENEL S
//
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