ID H2YFC9_CIOSA Unreviewed; 5795 AA.
AC H2YFC9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000004027.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000004027.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
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DR Ensembl; ENSCSAVT00000004087.1; ENSCSAVP00000004027.1; ENSCSAVG00000002380.1.
DR GeneTree; ENSGT01100000263532; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00063; FN3; 31.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05748; Ig_Titin_like; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 55.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR14340:SF24; -; 1.
DR PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR Pfam; PF00041; fn3; 31.
DR Pfam; PF07679; I-set; 22.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 31.
DR SMART; SM00409; IG; 23.
DR SMART; SM00408; IGc2; 19.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 17.
DR SUPFAM; SSF48726; Immunoglobulin; 24.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50853; FN3; 31.
DR PROSITE; PS50835; IG_LIKE; 21.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..60
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 166..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 261..339
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 344..442
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 453..547
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 553..649
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 653..739
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 746..839
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 845..937
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 941..1033
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1040..1132
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1138..1233
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1232..1325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1332..1426
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1432..1527
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1537..1617
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1628..1731
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1737..1832
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1836..1925
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1932..2025
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2031..2126
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2129..2217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2228..2321
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2327..2423
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2432..2522
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2529..2631
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2632..2730
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2730..2815
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2827..2926
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2927..3020
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3025..3116
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3123..3216
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3222..3318
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3398..3491
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3497..3592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3600..3694
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3698..3787
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3796..3890
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3896..3991
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 3997..4085
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4092..4185
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4191..4286
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4289..4385
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4388..4476
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4583..4677
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4680..4778
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 4783..4873
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4891..4968
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4977..5070
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 5103..5358
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 5421..5512
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5544..5635
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5706..5794
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1433..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4272..4293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 5132
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 5795 AA; 639376 MW; 241944E95B912B3C CRC64;
SRPNAEVRWF KGRAIIRDSE KYEIRAEGCK RTLVVLQCSF DDEKKYTCDA DDARTSAKLT
VQARAIKFLK PLEQKIRVTE REEVVFEIEL SHTDVEVIWY KNGAKMARTK NVELYTDGAV
HKMVIHRANM EDYGVEVVAQ AEEETSMTTL FIDGNIILIR IFVTEPPVKF PRTLSDKTCE
EMDRVVLECE VSRANANVVW LKNNEAIEAS DKYLVEVEGI IRRLILIDAS IEDNAEWTCD
GKDSKTVCNL IVKDGVKFTK PLSDVNVLEK DGAVLQCEIS DPDVKVRWYK DGLPITNSDR
VTIEANGKIH SVSLPWTLCS DTGSYQVVAE FAKSDAKLTV EAAPIMNMMQ SDIVLVAGEK
LRIRVPFTGS PLPNIEWTRD EKAIKDYIKT RWEKDEKLPL PGTAVIKNTD ASSEVTITDC
GRDDSGRYTI VSKNIGGTRT ASCKVLVKDT PGAPLPLVVS NVTKRGAKLS WKTPCNDGGS
KIQTYIVEKR RADGRGWVKL DSSVSATQFN VLDLLENFEY YFRVCAVNSI GQGVFAETTE
PILARDPTSI PDPPAHLRVT GDITKSAVSL VWKVPDTDGG SKIKGYHVEM QEGDSEEWIK
ATKHDQRSCE FVVPDLPQGK KYNFRVIALN AAGQGEPGYI AEPVIIQEKQ EMPEISLNKM
IVRVGEPYRI LVKISGKPAP TVTWEQDGKL VQTDSRFQIK TTPTTSALEV HKGERKDSGL
YKVTVQNDGG QRDGNIILAV VNKPTPPRDL DVKEVTHEHV LLTWEAPEDD GGSELLNYVI
EKRDISRMMW TTVNSTSLKT EFRISKLSEG SEYVFRVMAE NNQGCSNPAE TQGVVVKDRY
RVPDAPDALT IKEVHKDSVS LSWNKPYDGG KAIFNYVVEK REIKSERWWT NFKTVPKTLC
TVADLKEGVL YKLRVRAVNE AGESRPDHTV PVAPRQKLSS PSVEIDVKTL EGLTVRAGST
LRIPATIHGI PVPTAQWSTA DGNVVVTDDR ITCDTDSNSS LLTIRSAIRS DTQEYSLTAK
NEAGTKSAAV HVTVLDRPGM PIGPMSIEMT PEYAIISWMP PKDDGGSQIT NYVVEKKDTS
KQTWVVTASV TACAYPVPRL LEGNEYIFRV KAENKMGLGP AIESSPVVAK SPYDKPGAPS
APEITKIGNG TATIAWKAPD KDGGRDISGY FVEKREKKGV RWSPCNTKSI MDRRLNVLGL
SIGYDYQFRV AAENEMGVGE PSEPSKMAIA APSITLDASC RELLVVRAGQ DIVIEATIVG
KPKPTAMWTR GEDQIKSTSD GSVTAETLLN QSRVIIRSCK RSDAGNYVLT LENTSGKTSA
TAKVRVLDVP GMPEGPAKFS NVLSDRLKLI WNRPLEDGGA AITNYVIERR ETSRPTWAMV
SGSAQGTELA VQKLIQNHEY EFRISAENKY GIGQSLVTEP IIVKNPFSVP SAAEPPSVSN
AKKEGMTVSW KSPSEDGGKP ISGYYLEKRE TKAVQWVKVN RRPVSDRSIK VTGLIEGAEY
EFRVAAENVA GIGEFSLPSQ PATADDPKYP PAPPAFPKVL DTTRSTGTPA KLKIPVQGAP
KPEIKWTKDD ENLKEDTRVS VEVTAISTVV VFKEIRKEDA GKYIVAATNV VGKKTATIKF
VVVGKPGVPY GPCQISDLTA EHATLTWNAP KDNGAPKFDG GHRIAGYDVE RLNLPGKNWI
RCNVGNISAT NFEVTNLTPG SRYDFRIRAK NTAGSVSEPS ETTGPNVCKE EYDAPGTPGK
PEVTKATKTT MTVTWERPES DGGNEIIGYH LERHHKKDTW VKCPVPVRYM LTEYTVGDLV
ENREYRLRVA AVNKAGVGEF VMVSGKVVAK DVLLAPDMEI DAKIFMVVRA GDTAKFTIRV
YGKPSPAVRW CRDGRDIEVS PRVKFDHSTT HTTLIIEDTT KNDSGEYELV VKNAVGTKTA
TLRVVVMEKP APPTGPMEIK DVSAESITVA WGQPEEDGGT PVTHYTLEKL DCNIGWTEVS
GFVVRTSQKI TRLTTGQEYI FRVRAANKFG LSEPLDSAPV MARHPFNKPG TPSAPQVVSV
TNDSVVITWQ EPTNDGGSAI LGYHIERKDR NSIMWTKANS YIVRDSTFKC GNLSQGLSYE
FRVTAENLAG FGKPSDSTGS VTARDEVEPA SVDVDAQYRD VVCVKAGEAF TLKTYVSGKP
VPTISWEKDG NEFESGPRVS ILTTETTSNV TVKDAHRADS GTYTIKVHNL AGDRSIGINV
RVLDTPGMCE LVTVSGITAE KCNLAWQSPT LNGGAKVTGY SIEKRETSRL AWTVVVHGTE
FNQHKVTGLI NGNEYVFRVR AENKFGLGEP VETNPVVAKN PFVVADAPGV PEVSNIMKNS
CTVMWTRPES DGGAEITGYI VERREKNSAR WHRVNRRLVS DLRLRVTDLR EGSEQEFRIY
AENRAGVGQA SESSGFVTMT DPLYVPEAPG IPRVTDSTKS SLVEGKAGTT VQASILIKGK
PAPTTQWKRD GAELKMTSRV NYDTVEGNAI LTIKDADLKD AGNYQLVLEN SIGSKTIPVS
VRVLDKPGPP KGPVEFSGVT ADSLVLSWSA PEADGGAAIN NYIVDMRETS GDATEWRMIS
GSTARNSLKV TRLRPGMEYA FRIRAENRFG IGHGLESPSI KAQFPFKTPG SPSAPTVVAT
TRETMTIKWE VPMNDGGSKI LGYHVEKKDR NSILWIKCSK TLVSGTDYKI TNLQESLEYE
FRVYAENAAG FGKTSKSSDS AIARDAVDPP HMDARFAELV TVRAGRTIKI EAGIRGKPTP
IITWKKDEQE FKLSGRISVK NTDVSTCLEI TDADRDDTAA YSLAVQNFAG SRSLSIQVKV
LDKPGRPTGP ITISGTTAEK CTISWRAPER DGGAPIINYV VEKRETSHLA WVLVNPSVEG
TTCKISKLLA DNEYIFRVRA ENKYGVGDAL ESVEIIAKNP FTTPSAPQSL EVTSVNNNSV
TLAWGRPKHD GGSEIAGYAV EKKIRSGLRW IRANKKTILD MRYKVQDLSE NQEYEFRVFA
KNDKGLSDPA TLNQVITVKD IVEAPEIHLR DLPVGGIHKK AGSNINISIP ISGKPKPEVV
WKKNGEVIKQ TTRVCTVSSA IQTSICIKSC KLEDTGNYEI AVTNPSGTTK GVLSVTVLDK
PGKISDLVIK SVTENSVSLE WKKSQEDGGC QISNYVVQIR DAESDVWVDC AATAVRPRIK
VNKLTLGKEY QFRVSGENRY GCGEFVTSEK VLVKYPFSKP GPPGIPAVTL VSSDHVVLRW
HEPVHDGGSP IISYHVEVKD RNSILWRKAN RMDIRETNFK ATGLQPGLTY EFRIIAKNTS
GSISAPSEPS EKVTCKDSFT PPRLDLNGNL KDTVVVKAGE TITLSASIFG KPVPNATWTR
NNDSTRDDSG DYVLHLKNTA GSRAISITVK VLDRPGQPIG PLTISEVTSE RCRLAWRAPE
NNGGAPVTHY NIEKRETSRL TWTLVESGIE GVTTKVHRLL KGNEYIFRVI AVNKYGRGVP
LESVPVIAKN PFSVPAAPGK PQVSTVMKNS AVLTWTRPTS DGGSDISGYH IERKERNSLR
WTRAVRRSVP SLHHKVTGLS EGSEYEFRVS AENAAGIGPP SECSTPALCK EPVYVPVPGA
PASCTVSYAC KDSIVVNWQE PVKDGGSQIT GYHLEVKDRN SILWKKANRV VIRSTHFRVL
GLQEGLEYEY RVSAENAAGI GKPSRPSEAA FAHDFRPPRI NLDAHLLDEV TVTAGSTLRL
HAGISGKPEP AITWSNNGND IREDLRHVLH TTIDHCSILI KDCSKSDSGV FTINAKNACG
EKSANVKVLV LDKPGPPTGP IKFSRVTDSR VTCSWEPPMQ DGGSKIINYI ISKRETSRLA
WSVVSEKEEL CTLTVQRLIK NNEYQFRIQA VNKFGVGEPL DSEPVVAKNN FTEPSAPGQP
EINNVCSSGC TVMWSRPESD GGADIDGYIV ERRERKSARW IKCNKKIVRD LRFKLSNLSE
NNEYEFRVAA ENAAGIGAYS HISLPVVMRD PIDLPGPPNA SLRKTMLVRA GNTVNISIAV
KGRPTPNVTW TKDNLNVTKN PRVHVDNVDG KTILVIQDCT RDDTGKYALA LENASGVART
FVSIRVLDTP GQPGLLNVKQ VTKEYAIITW DAPLIDGGSE VINYHVDKRE TTHRSWSSVT
SDCKRLTWKI DGLNKGSKYV FRIAAENKYG LGEFTESQEV VAKHPFRTPT VPPQPEVVEI
SADVMTVVWK ECHSDGGSQI TGYHIEKKER NAILWTKANL ATLRSREFKA TGLTEGLEYQ
FRVYAENMAG KSAPSEASKP ERAHNVVSPP TCPDWTDITR DSVTLVWKPP KSDGGSKIIG
YNLEKRSGAD GRWLKCNYTN VQDCEFTATA LNSGEKYQFR VTARNASGTV SKPSIPSAEV
VCHDDFQPPM IQLDTDILDG VNIRAGVTLR LKANVTGKPA PKIVWTRDGK EFVSNAQTEI
TKNKNVCMVT IKDTTRLNSG CYVISARNPC ATKTMEVKVL VLDKPEVLQS FTEPIVVRKG
GVICLKVPFK CRPSPQASWK KISGPEVDLN VRAMIALHTD SAELVIKGVD RRDAGEYEVT
LSNKLGKISV SIRVQVIGKP DAPEGPLQFG DIQATSVNVV WKPITNDGGS EVTNYVVEKR
EVGKTAWMTV DSKIRSTQCT VKGLTEGKEY FFRVFAENAF GLGDALKCIE SVTAKNPLFP
PQPPQLVEIN EVRKDKVFLA WTRSRDDGGS RVTGYFVERK EAGSERWVRS HEDMIRDRIY
QIGGLDQGAE YEFRIFAIND QGRSRPKMME TPVSTKKAAG EKPVIVETLQ TVMGVRESTA
TLTCTVSGRP MPDITWWYKG GREITGCSQY KISEAKGNHY TLVVHNVTVD HEGPYTVRAT
NQAGSISQTV EMTVQLPAKI NLPKYMMTEA IVCRVHEVVS IKVPIEGKPQ PDITWSKAGK
LVSADGHRQF ITASSFTSMT ITNADRRDSG FYNVIVKNRF GTNQATIELL VGDVPAKPES
LKVSNVTRDS VDLTWKEPSD NGGKPVLKYV LEKCTTSSDC WVKVSSSGTC KYTVCNLSGK
TGYLFRVRAE NEYGQSKPSS PSDAVTTKED RMMAANYDDM VDATEKFVAS EARINKSNVM
EKYQIMEQLG RGTFGTVHRA REILTGKTYA VKLCRFTDET EKVPINREVS IMRKLQHPRV
LQLHEVFDTK LETALVVQFV SGGDLLERII ATKFELTENA CAYIIKQVLE ALAYVHSQNV
AHLDIKPENI LFITRKSKKI KLIDFGVSRE LKTGEGLRIS FGTPDFCAPE VVQNDTVGCA
TDMWSVGVLT YLMLTGLSPF QGENDNDTLR NVSDADYNFE HEAWRFISDD ALDFIDRLLL
KDKRERMTAD DALEHPWLRT GVVRSDDGNY KCRVENAFGS STQTCEVEWT RTRRSIYLNR
HKKRGRKTAA SEFSRIVKCP PEFTLPLYNR TVYTGDTAIF TITVTVHPTP EISWYHKGQK
IIINSEETHY AEIREKGLYT LEIRKSQLED SGEVIVQAKN AYGEDECKAM LTVQDISSGV
EFTSSKLKAR SDKGVTLSAA DYAPSFQLRM RSHVVPCGMS TKLSAFVRGR PEPQVTWYRN
GTELASGGTK YYVSNIGGVT TLEIVRCHEG DSGTYRCSAK NYLGENSDYS TLEVTGSEFE
STASKRGVQD FHMTMDMVDV RSTISRSRFD AISQATERDA SRSSTAFDDQ MSHASGFTPY
VGSETPYFVI QPKSQYVLEG DSAYFAAQCD GKPSPKLTWY HDGRIIKDNE KYSLGAIRGK
RTLEIRDCQV IDVGNYVCIA ESSKGSATTE FTLDV
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