ID   H2YJD5_CIOSA            Unreviewed;      1343 AA.
AC   H2YJD5;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005434.1, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Proteomes:UP000007875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA   Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA   Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA   Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA   Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA   Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA   Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA   Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA   Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA   Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA   Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA   Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA   Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA   Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA   Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA   Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA   Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA   Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA   Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA   Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA   Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA   Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA   Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA   Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA   Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA   Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA   Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA   Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA   Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA   Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA   Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA   Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000005434.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   Ensembl; ENSCSAVT00000005506.1; ENSCSAVP00000005434.1; ENSCSAVG00000003251.1.
DR   GeneTree; ENSGT00390000006601; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039891; VWA8.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR21610; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR21610:SF9; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF07728; AAA_5; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT   DOMAIN          1155..1337
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1023..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1023..1041
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1343 AA;  152933 MW;  D809E70FBB4465F9 CRC64;
     MLRLFKSEKS VRRINHLCSI LNKDHQHLTC SRHRHDGYVS IGNVQVPVKT PKNPELVPYA
     YVLENAELPQ SALRHMKWMA QKDLLGQDVF LIGPPGPLRR VLAMQYLELT RKEVEYISLS
     RDTTESDLKQ RREMRKGTSF YIDQCAVRAA VEGRVLIIEG VEKAERNVLP ALNNLLENRE
     MQLDDGRFLM HHKRYDQLLQ DHSKETLDKW QLVRVSEDFR VFALGLPVPK YRGHPLDPPL
     RSRFQARDVY HLGFSVSINC WTIVIDYYEI NKTSYFLVFL HTVLNFIIFY LQDKHEYLSS
     QLTCMLARAT IQQKMFFNII YVNNLSFQFP GYPIQNLLSR LYPYKLVLNK EGTQAVEDIY
     QKFELSSSSA NSESLALHNI NVKNNHKANV SLHNNNENHN FEVSCGDHTY GPRSSKDEFV
     ATSYHQRLLA DLMLSHGAMD MCIIGGKGCG KSSVLREFAR LLSYRTEPVL MYQDMTARDL
     LQQRYTLPNG DTVWKISPLI EAALEGGMAV LDGLNRVNPA VYRIHPSFRM IGLAEPPTTG
     SSAQQWLNPE LLTLFLYHHM EPLSVNNELE VIQKLHLAVM KDMLQDYNLG EHILIVGNQG
     VGKNKIVDRF LHLLNKPREY LQLHSCHAVD NPSVASELDM LRQYGANVPE SSLKKLVAAF
     GELRDLADRG LISYPYSTRE VVNIVKHLEK FPKEGLANVV RNVFDFDAYS KETKEQLSSV
     MHKHGIPIGA KPHDVRLAKP LPLSAPKLSG YWNILHQSSS YCDGPVHLTV QNYEIERTED
     RGLDFSEQFA HWQLPQFFRT NIITDIASPE DDVPTKLTQI KEEGVDLGFG SFVTPINRIL
     VDKDSYAKCV VGFPHLTATN EIYSFPRSNS SLEDSFIEKG RTIYRGLTKF VPPKPPCQIL
     SSSNQVVKVV SLKTVPEKAF DQGTQPRMTS HCLEVADLGQ HMLRYVPIPQ AVAESPYVSW
     QSSISESGYH LARGRDDVLY TVDTGGCVRE WETGLLNLQR SLAEWRAMIG SDDMEDKLQI
     TTERESGEDV TAPKHGKIDP KNAPHVGGNT WAGGTGGRDT AGMGGKGGPY RLDMGHDVTQ
     IPDWEKEAVP EHVKKAAREV AQKAFKERLR EIRMSEFDAD MYEKFSSHVR KQVNFKKLNY
     AHLEQPGTPQ QKPKRIRVVM DVSGSMYRFN GLDNRLERTV EAACLVMESF EGYKEKFKYE
     LWGHSGDGFD IPLVTYEKPP TNNKERLEVM KTMHAHAQFC MSGDHTLEAA EYAVKNIKEQ
     EADEYFVVVL SDANLERYGI RPMQFAEVLT SDDEVNAFVI FIGSLGDQAE RLKKQLPLGR
     SFVCMDTKNI PQILQQIFTS SLL
//