ID H2YJF4_CIOSA Unreviewed; 1158 AA.
AC H2YJF4;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=SMC hinge domain-containing protein {ECO:0000259|SMART:SM00968};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005453.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000005453.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR AlphaFoldDB; H2YJF4; -.
DR Ensembl; ENSCSAVT00000005525.1; ENSCSAVP00000005453.1; ENSCSAVG00000003260.1.
DR GeneTree; ENSGT00550000074857; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 2.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 521..641
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 760..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..280
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 317..496
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 802..920
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 972..1013
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 760..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 129789 MW; 0B3E04C9CB678003 CRC64;
MYIKSVTVDG FKSYAQRTDI SGFDPLFNAI TGLNGSGKSN ILDSICFLLG ITNLSQVRAT
NLQDLVYKNG QAGINKATVS ITFDNSNKDQ SPMGMEAHNE ITITRQIVIG GRNKYLINGV
NAQNSRVSDL FRSVGLNVNN PHFLIMQGRV TKVMNMKPPE ILSMIEEATG TSMYESKKDS
AQRMIEKKEN KLNQINRTLD EEITPTIQKL HDERSSYLEF QKVQREVERL SRLLIAYHFL
TVERVANNAS GEIEEMNGEK EKLESEVYQL QDQYRNMGQE IVQLEKVLDE DSKAKLSQLE
STLGSKEKIE AKAQSNLSNQ REVINSEKRK LKGLQKSKSE CESAIKSKSK ALDSLQSACD
KLESESVKLA EAYTAAEKHF QAVTTGLASS DTGEEASWQA QLLKAKKDIS QLQTETKQVI
SINVGTTKQE LKSKQSELKK TEATYKQDLE VLKKVEKRLV EIKTQMEKLN YTEGEEEQLK
AQKHDLSTKI QKMSRLTQGL FNKFPNLQFE YRDPESNWDH RRVKGLVADL VDVKDVANAT
ALEVVAGGRL YNVVVDTHET GAKLLKNGQL KRRCTIIPLN KVAARTINKE VVTHAKSIVG
RDNVNLALSL VGMDEEIRKA LEYVFGGALV CDTMENANKV AFNPNVKTRT VTLAGELFDP
SGTLTGGARP KVTPVLAELK EIKSVQQDTS EDYAALDVKL QEVTHVSAKY HDLKNQSTLK
EREINSLKQR ISDTSHGRLI ASAKMQDQCA ELERKIANAP AERERELKEA EKQMNKAGSA
AEKAGHSAAA KRDVSKDSNF IRIFSSKELN TMKLEVQELE KEVNDYGEQI ARVESSIEEA
QVVYQSVKET VDVAADSVKS AKAELQQHRD HIQETSHDIQ QRIKQRELVQ QEAGKANKRL
QEQTNAIEKC LRESKDAKHE WIANEKSLFG RQSSPYDFEA NPPKEASRRL EKLKERQEKL
STSVNMRAMS LLGKAEEKYN ELIKKKMIVQ NDKEKIQKTI EELDQMKNKA VTKAYVQVNK
NFGEIFSTLL PGATAKLAPA EGSSVLAGLE FHVGFGDVWK TNLNELSGGQ RSLVALSLIL
AMLLLKPAPI YILDEVDAAL DLSHTQNIGG MLREHFKHSQ FIVVSLKDGM FNNANVLFRT
KFVDGVSTVA RYTQSTHS
//
