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Database: UniProt
Entry: H2YKN7_CIOSA
LinkDB: H2YKN7_CIOSA
Original site: H2YKN7_CIOSA 
ID   H2YKN7_CIOSA            Unreviewed;      1708 AA.
AC   H2YKN7;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005889, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000005889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000005889}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000005889}.
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DR   Ensembl; ENSCSAVT00000005964; ENSCSAVP00000005889; ENSCSAVG00000003521.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00054; EFh; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     72     91       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    187    206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    314    336       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    577    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    612    633       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    708    730       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    813       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1026   1045       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1065   1082       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1094   1114       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1161   1185       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1238   1259       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1279   1302       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1397   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1427   1446       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1487   1515       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1629   1664       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1642   1653       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   1708 AA;  193796 MW;  9043D96B0ACECB8E CRC64;
     PLARLKQQRR LTIGYSKSPE KLLEPIEDPD PFYKDKKTFL VLNENRLIFR FSKEKSLFLF
     GKDSKIRQRY TYFNGLVIVT ILLNCLVMMI TGNDKPQWHI FTAIYTIEAT VKIVGRGFAL
     HRFSYLRDPW NWLDFIVILA ADSSKISSLT FLRAIRVLRV FKTVSVIPGL RMIVSALVAS
     TKALKDAMLL SLLGFSMFSL VGFQFFRGTL HHKCVLRPPA MLPFPPSCYE SYWTKNPQKY
     LRKGADYRLC GNISGTLQCP AYTICLKVGS NPNFGFTSFD NFPFAFLSVF RLSLQDNWEE
     LYLQVLETSG PVSVLFFLTM IFLGSYYLVN LILAVVASSY EGQRKSVENA LEEEKVELLN
     EKVFCLVQFS CEIITAIISK IYAILTLSGS LTNYDERAVV LSFLETSMGS LSRTLLLQLG
     GIKLLIRMAF TGPRFDSRTL SLARSFYDSR LGVTLTVWPR INCFLQEILT KRRNAARTFA
     SLKAAENWQP QKKKFYSLGS WYKCGDSSQQ GKNIIWNYFL GVIVHVKRAE KTTRVVIPSD
     LIARTSQCHL SKSDQVLWSC CEGSSFICRI RSKLHKFFTT SAAEMITVSL VILNTCFMAM
     EKEPKDQFFK NLLYTSNVVF TVLFAIEMGL KIFALSPYHY FKASWNIFDF VVVTLSVFEL
     VVSDKLPDGL SVLRTFRLIR LVRILKLAKS WPTLSKLMQM IADSLSKVGY LTLVLLIVLV
     IFALAGMQTI GTQFYMDKTT GLPLRWHMNS FPHAFLVVFR IQCGEWIQSM WSCMNSVRSE
     GADGLIPVCL FIFLGVVFVG NLVVLNLFLA LLLNSFNSDE LNAGGKRGSG AKKFLRSLRN
     AGRKALPKLP ASINRKRKIS PGSNTSETSE EKLSTHESTP TAIHIKDAQN ENGHSNNISV
     YVTNGIWING KPLANGTSDS DSKYTISLEG VHSDTEEWKN EMALPSTNHQ KNNSVDCGTT
     TTDVCRSTWF QVKTCQSNGR TCTSSGTKSK SHWSYSISLS CGKSCEQLQE RWCRFRATMN
     MVVQHNIFES FIIFVILLSS VALVFDDVTL PTKPKFKYVL SIFDRFFTAI FVIEMLMKWV
     GFGFRKYFTN GWCLLDFFIV VVSLISLSLE IVALQQQGKS NTDLSSLRVL RSLRAFRPLR
     AMSRFEGIKV VTDALFRSIP AILNVFVICL IFWLIFAIMG VNLFAGKMAS CNYPHLAKLY
     PPPPIEVTDR DSCNCLANIT GGKVHWTNLP INFDNVMIAY ISLLQVATFK GWMPIMYAAV
     DAPMKIGEQP TRDANIVNYF FFVGFIIFGA FFTLNLFISV VIDNFNQQKK KFEFAGTELF
     LTDTQKKVYS AMKKLKAKLP KTLFPVPKSR WRERLYLFTT GDKFELGVMV ITILNLLAMA
     LEFEGMSAEY RRAIRNINYG FVVVFTIEIT IRIIAMGKSY FYVPWNVFDF LLIFASVLAN
     VIPVLITHTN NNTVSSVTST PWLPMFRMVR VARILRVARV ASGIRTLLFA LMLSAPALFN
     VGSLLFLFVF IYAIFGMNQF AYVEKKGALN EILNFETFPN TFLLLFQMST SAGWDGFMEP
     TLYVDGNSEC KLGRDGQKGT CMSTSFVGYF YFVSYLLVTF VIITNMYIAI ILENFDLATK
     DNEEALTADD FEHFFDMWQR YDKNGNGKLG VSELSELLHN IDRPLRIRKP NKHHIANMRI
     PMDSVGDIEI LDVASALTKK IIGKSAEL
//
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