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Database: UniProt
Entry: H2YKP2_CIOSA
LinkDB: H2YKP2_CIOSA
Original site: H2YKP2_CIOSA 
ID   H2YKP2_CIOSA            Unreviewed;      1677 AA.
AC   H2YKP2;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   10-MAY-2017, entry version 38.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000005894, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000005894}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000005894}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000005894}.
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DR   Ensembl; ENSCSAVT00000005969; ENSCSAVP00000005894; ENSCSAVG00000003521.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00054; EFh; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     54     74       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    175    194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    324    346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    547    570       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    603       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    678    700       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    754    783       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1004   1023       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1043   1062       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1069   1091       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1138   1162       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1211   1232       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1252   1275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1370   1388       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1456   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1558   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1598   1633       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    1611   1622       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   1677 AA;  190904 MW;  9EDA6D331BCB96DD CRC64;
     PEKLLEPIED PDPFYKDKKT FLVLNENRLI FRFSKEKSLF LFGKDSKIRQ RYTYFNGLVI
     VTILLNCLVM MITGNDKPQW SERYVEHIFT AIYTIEATVK IVGRGFALHR FSYLRDPWNW
     LDFIVILAAD SSKISSLTFL RAIRVLRVFK TVSVIPGLRM IVSALVASTK ALKDAMLLSL
     LGFSMFSLVG FQFFRGTLHH KCVLRPPAML PFPPPEPSHE RNISNQPLTT FNSTGYKFDW
     IQWTKNPQKY LRKGADYRLC GNISGTLQCP AYTICLKVGS NPNFGFTSFD NFPFAFLSVF
     RLSLQDNWEE LYLQVLETSG PVSVLFFLTM IFLGSYYLVN LILAVVASSY EGQRKSVENA
     LEEEKVELLN EKVFCLVQFS CEIITAIISK IYAILTLSGS LTNYDERAVV LSFLETSMGS
     LSRTLLLQLG GIKLLSPIFT LPIRMAFTGP RFDSRTLSLA RSFYDSRLGV TLTVWPRINC
     FLQEILTKRR NAARTFASLK AAENWQPQKK KFYSLGSWYK CGDVIIKWSC CEGSSFICRI
     RSKLHKFFTT SAAEMITVSL VILNTCFMAM EKEPKDQFFK NLLYTSNVVF TVLFAIEMGL
     KIFALSPYHY FKASWNIFDF VVVTLSVFEL VVSDKLPDGL SVLRTFRLIR LVRILKLAKS
     WPTLSKLMQM IADSLSKVGY LTLVLLIVLV IFALAGMQTI GTQFYMDKTT GLPLRWHMNS
     FPHAFLVVFR IQCGEWIQSM WSCMNSVRSE GADGLIPVCL FIFLGVVFVG NLVVLNLFLA
     LLLNSFNSDE LNAGGKRGSG AKKFLRSLRN AGRKALPKLP ASINRKRKIS PGSNTSETSE
     EKLSTHESTP TAIHIKDAQN ENGHSNNISV CFCYIRYVLD VKNELKLYVT NGIWINGKPL
     ANGTSDSDSK YTISLEGVHS DTEEWKNEMA LPSTNHQKNN SVDCGTTTTD VCRSTWFQVK
     TSNGRTCTSS GTKSKSHCCG KSCEQLQERW CRFRATMNMV VQHNIFESFI IFVILLSSVA
     LVFDDVTLPT KPKFKYVLSI FDRFFTAIFV IEMLMKWVGF GFRKYFTNGW CLLDFFIVVS
     LISLSLEIVA LQQQGKSNTD LSSLRVLRSL RAFRPLRAMS RFEGIKVVTD ALFRSIPAIL
     NVFVICLIFW LIFAIMGVNL FAGKMASCKW KETGQKVWHK QDYANCNCLA NITGGKVHWT
     NLPINFDNVM IAYISLLQVA TFKGWMPIMY AAVDAPMKIG EQPTRDANIV NYFFFVGFII
     FGAFFTLNLF ISVVIDNFNQ QKKKFEFAGT ELFLTDTQKK VYSAMKKLKA KLPKTLFPVP
     KSRWRERLYL FTTGDKFELG VMVITILNLL AMALEFEGMS AEYRRAIRNI NYGFVVVFTI
     EITIRIIAMG KSYFYVPWNV FDFLLIFASV LGKHTLIISY LTYFSVTSTP WLPMFRMVRV
     ARILRVARVA SGIRTLLFAL MLSAPALFNV GSLLFLFVFI YAIFGMNQFA YVEKKGALNE
     ILNFETFPNT FLLLFQMSTS AGWDGFMEPT LYVDGNSECK LGRDGQKGTC MSTSFVGYFY
     FVSYLLVTFV IITNMYIAII LENFDLATKD NEEALTADDF EHFFDMWQRY DKNGNGKLGV
     SELSELLHNI DRPLRIRKPN KHHIANMRIP MDSVGDIEIL DVASALTKKI IGKSAEL
//
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