ID H2YNU8_CIOSA Unreviewed; 868 AA.
AC H2YNU8;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Small-subunit processome Utp12 domain-containing protein {ECO:0000259|Pfam:PF04003};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000007006.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000007006.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the WD repeat PWP2 family.
CC {ECO:0000256|ARBA:ARBA00010226}.
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DR AlphaFoldDB; H2YNU8; -.
DR Ensembl; ENSCSAVT00000007096.1; ENSCSAVP00000007006.1; ENSCSAVG00000004186.1.
DR GeneTree; ENSGT00550000074981; -.
DR HOGENOM; CLU_010458_0_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR027145; PWP2.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19858:SF0; PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG-RELATED; 1.
DR PANTHER; PTHR19858; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 336..377
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 378..419
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 464..505
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 735..839
FT /note="Small-subunit processome Utp12"
FT /evidence="ECO:0000259|Pfam:PF04003"
SQ SEQUENCE 868 AA; 96177 MW; 84D347544780BF90 CRC64;
MKFNYKFSNL VGTVYRKGNV TFINNGDSLV SPVGNRISLF DLKSNKSETL PVTTKYNIVC
VAVSPDGCTA ILVDEEGEAS LISFISKSVL HTHHFRKPIK CIKFSPDGSK FAVTKDNLVL
VYHAPGRNRE LNPFKLIRTF YGAYNDTTCI DWTSDSRAFA VGGLDMNTRV YAAIKCDNLV
VYSLGAHKDE IVGCFFELNS LDIYTTSRDG ALNVWECDTP LEGLKLAQSD NYECIAPHIL
TSTPPRYFFN KEGDFNHVTS TAFHPKTHIL VTGLASGSFH IHEMPEFNLI HSLSISEHQI
TASAFNVTGD WLALGSSGLG QLLVWEWQSE SYILKQQGHS NGMCCLDYSP DGRFIVTGGE
DGKVKVWNTS NGFCFVTFSE HESTVTAVRF TSSGHVIMSS SLDGTVRAFD LHRYRNFRTF
TSPRPSQFVC MGVDGSGELV AAGSRDSFEV FVWSVRTGRL LDVLAGHEAP VSSLQFSPCE
SLLASGSWDR TVILWKIGDE KGARESIDVG HDVMAVTYRG DGKELAVSTL NAEITFWDVK
TATQNGSVDC RFDIGCGRGE LDRVSAKTSS FGKSFDALCY TADGSAIIAG GQTKNVCVYH
VENKLLMKKF EISSNFSFDG MEEFLDKRKM TEFGPSALID MDTDEKIKLP GVRVGDMGAR
AFHDEVRVSG VCFSPTGREW AAVSTEGLLI YSLDANLVFD PFNLDMDITP ESIRDASQVG
GKEYSGSIMM SFRLNDKPLI REVLEAVPSS SIELLCERLP PSYVDKLLDF LASEMESSPH
LHFILLWMRA ILTKHGPHLK SKSNHVVAVM RHVQKSLTRK SETICKLLDA NFYQSQYIIS
LAQLNRRLAD TSLRHTDSDD DTMLVCSD
//
