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Database: UniProt
Entry: H2YSX0_CIOSA
LinkDB: H2YSX0_CIOSA
Original site: H2YSX0_CIOSA 
ID   H2YSX0_CIOSA            Unreviewed;      1549 AA.
AC   H2YSX0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000008430, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000008430}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000008430}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000008430}.
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DR   Ensembl; ENSCSAVT00000008539; ENSCSAVP00000008430; ENSCSAVG00000005006.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     42     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     79     99       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    111    129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    173    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    422    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    459    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    525    552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    611    639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    814    833       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    853    876       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    897    930       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1022   1048       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1099   1117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1129   1150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1162   1179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1226   1244       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1324   1347       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       38    320       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      421    646       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      779   1055       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1098   1357       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1359   1429       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   DOMAIN     1430   1498       Ca_chan_IQ. {ECO:0000259|Pfam:PF08763}.
FT   COILED      642    673       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1549 AA;  176625 MW;  1F11DFDC719C758C CRC64;
     TRKRKNAQQD MDKAETSLLC LSLKNPFRRA CLKIVEWRPF DVLILLTIFA NCCALAIYVP
     FPGEDSNETN EKLEKVEYVF LGIFTVESFM KIIAFGLAFH PNAYLRNGWN ILDFIIVIVG
     LISIVFEMAD VGSTDKVRAL RAFRVLRPLR LVSGVPSLQV VLNAIIRAML PLLHIALLVI
     FVIVIYAVVG LELFKGKLHK TCYFNETGMT NIIANDDPQP CAPLGYAGRH CPEDTVCKDG
     WVGPAHGIIN FDTFYFSFIT VFQCITMEGW TEVLYYTNNA MGSYLPWIYF VSLIIVGSFF
     VMNLILGVLS GEFSKEREKA NARGEFQKLR EKQQLDEDVR GYMEWITQAE DIDPVNEDDD
     IDEKRCLISN RGRNRTLPTS LEHLSFLSMV IPCPLGSLIR RRWKRWNRKT RRKCRLMVKS
     QTFYWLVIVL VFLNTLSLAT EHYQQPDWLT TVQDISNKVL LGIFTIEMLL KMYALGMQVY
     FVSLFNRFDC FVVCGGIVEL VLTGAKVREC VNSKTHGYWS SLSNLVASLL NSIRSIAGLL
     LLLFLFIVIF SLGMQLFGGR FNSIAEGDTK IRSNFDTFLQ ALLTVFQILT GEDWNVVMYY
     GIRAYGGASS IGLITSIYFI ILFVCGNYIL LNVFLAIAVD NLADAESLNV AQKEKEEEQK
     RKKTLRLKKL RLVHISPPSG KTTISLLTHH WNPQELIQEE GDSKCGYGGG RRRTNSDRHL
     PEEGDSDAEP ELPSGPRPRR MSELNLKQKK SPMPVATSFF VFSHTNPFRC WCYFIANNNI
     FNNGIFVCIM LSSVALACED PIDSKADLNE VLKYFDYVFT GIFTAEIILK MVAYGVILHK
     GSFCRSLFNL LDLLVVAVSL ISILGNSDGF SVVKILRVLR VLRPLRAINR AKGLKHVVQC
     VIVAISTIGN IFVITTLLQF MFACIGVQLF KGRLYSCTDE SKSTREECKG DFYTIPNDGI
     GQPRIKQREW VNNDFNYDNV LNAMLTLFVV ATFEGWPALL YKSIDSWKEG MGPKYDARPA
     VALFYFIYII VIAFFMMNIF VGFVIVTFQE QGEQEYKNCE LDKNQRQCVE YALKAKPTRR
     YIPKNPWQYK AWFVVNSTYF EYFMLVLILL NTVCLAVQHY QQDENLTRIL NYMNFVFTTL
     FTIEMIFKLI AFKPRGYISD PWNIFDFLVV IGSIVDILLS KIDTGGDKSF SINFFRLFRV
     LRLVKLLSRG EGIRTLLWTF IKSFQALPYV ALLIVLLFFI YAVIGMQVFG KVKTIDGEQI
     NRNNNFQTFI QSVLLLFRCA TGESWQEVML AAASGKECDD RSDWNGTGTA TPEDKFTCGS
     DFSYTYFLTF YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKT VWSEYDPEAK
     GRIKHLNVVK LLRRIQPPLG FGKLCPQRMA CRKLVTMNMP LNSDGTVMFN ATLFALIRTS
     LNIKTEGNID QANEELRAVI KKIWKRTSIK LLDQIAPPAG NGSDITVGKF YNATYLIHGC
     IVRKFRKRYD VKDSRPTCTI IKMCSAGLRA LQDAGPELKR AISGGIAHD
//
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