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Database: UniProt
Entry: H2YSX6_CIOSA
LinkDB: H2YSX6_CIOSA
Original site: H2YSX6_CIOSA 
ID   H2YSX6_CIOSA            Unreviewed;      1626 AA.
AC   H2YSX6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Enterogona;
OC   Phlebobranchia; Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000008436, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Ensembl:ENSCSAVP00000008436}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E.,
RA   Ait-zahra M., Allen N., Allen T., An P., Anderson M., Anderson S.,
RA   Arachchi H., Armbruster J., Bachantsang P., Baldwin J., Barry A.,
RA   Bayul T., Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Borowsky M., Boukhgalter B., Brunache A., Butler J., Calixte N.,
RA   Calvo S., Camarata J., Campo K., Chang J., Cheshatsang Y., Citroen M.,
RA   Collymore A., Considine T., Cook A., Cooke P., Corum B., Cuomo C.,
RA   David R., Dawoe T., Degray S., Dodge S., Dooley K., Dorje P.,
RA   Dorjee K., Dorris L., Duffey N., Dupes A., Elkins T., Engels R.,
RA   Erickson J., Farina A., Faro S., Ferreira P., Fischer H.,
RA   Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G., Gnerre S.,
RA   Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
RA   Hagopian D., Hagos B., Hall J., Hatcher B., Heller A., Higgins H.,
RA   Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E., Iliev I.,
RA   Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M., Karlsson E.,
RA   Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E., Labutti K.,
RA   Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O.,
RA   Lui A., Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J.,
RA   Manning J., Marabella R., Maru K., Matthews C., Mauceli E.,
RA   Mccarthy M., Mcdonough S., Mcghee T., Meldrim J., Meneus L.,
RA   Mesirov J., Mihalev A., Mihova T., Mikkelsen T., Mlenga V., Moru K.,
RA   Mozes J., Mulrain L., Munson G., Naylor J., Newes C., Nguyen C.,
RA   Nguyen N., Nguyen T., Nicol R., Nielsen C., Nizzari M., Norbu C.,
RA   Norbu N., O'donnell P., Okoawo O., O'leary S., Omotosho B.,
RA   O'neill K., Osman S., Parker S., Perrin D., Phunkhang P., Piqani B.,
RA   Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V., Raymond C.,
RA   Retta R., Richardson S., Rise C., Rodriguez J., Rogers J., Rogov P.,
RA   Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S.,
RA   Stetson K., Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P.,
RA   Tenzing P., Tesfaye S., Theodore J., Thoulutsang Y., Topham K.,
RA   Towey S., Tsamla T., Tsomo N., Vallee D., Vassiliev H.,
RA   Venkataraman V., Vinson J., Vo A., Wade C., Wang S., Wangchuk T.,
RA   Wangdi T., Whittaker C., Wilkinson J., Wu Y., Wyman D., Yadav S.,
RA   Yang S., Yang X., Yeager S., Yee E., Young G., Zainoun J., Zembeck L.,
RA   Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000008436}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCSAVP00000008436}.
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DR   Ensembl; ENSCSAVT00000008545; ENSCSAVP00000008436; ENSCSAVG00000005006.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007875};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM      6     25       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     37     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     71     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    131    153       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    249    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    427    449       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    512       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    524    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    563    586       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    598    624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    914    936       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    948    967       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    987   1010       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1031   1064       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1156   1182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1233   1251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1263   1286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1298   1325       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1346   1374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1454   1477       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        2    282       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      389    631       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      913   1189       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1232   1487       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1489   1559       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   DOMAIN     1560   1626       Ca_chan_IQ. {ECO:0000259|Pfam:PF08763}.
FT   COILED      627    653       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1626 AA;  185992 MW;  C81744AE0B276C27 CRC64;
     PFDVLILLTI FANCCALAIY VPFPGEDSNE TNEKLEKVEY VFLGIFTVES FMKIIAFGLA
     FHPNAYLRNG WNILDFIIVI VGIVFEMADV GSTDKVRALR AFRVLRPLRL VSGVPSLQVV
     LNAIIRAMLP LLHIALLVIF VIVIYAVVGL ELFKGKLHKT CYFNETGEYC MTNIIANDDP
     QPCAPLGYAG RHCPEDTVCK DGWVGPAHGI INFDTFYFSF ITVFQCITME GWTEVLYYTN
     NAMGSYLPWI YFVSLIIVGS FFVMNLILGV LSGEFSKERE KANARGEFQK LREKQQLDED
     VRGYMEWITQ AEDIDPVNED DDIDEKREFS PWTKYNLLLY VLADLLPDFK AKRDISLCHY
     CCKNNKLLDS FHGQSPQEHW KCRLMVKSQT FYWLVIVLVF LNTLSLATEH YQQPDWLTTV
     QDISNKVLLG IFTIEMLLKM YALGMQVYFV SLFNRFDCFV VCGGIVELVL TGAKQLNHFD
     LDKLKKQQYI ICFIVTNILF NMYWSSLSNL VASLLNSIRS IAGLLLLLFL FIVIFSLGMQ
     LFGGRFNSIA EGDTKIRSNF DTFLQALLTV FQILTGEDWN VVMYYGIRAY GGASSIGLIT
     SIYFIILFVC GNYILLNVFL AIAVDNLADA ESLNVAQKEK EEEQKRKKTL RLKKKTASLH
     LTHSKTVSLH LYTAQETTMG CQNSYTVKYP NVLFKWFIHI MKKLKCYIKT NDRTTKIVPR
     VKNTLYQNKI NALIIRTTIT HSGNPTMGCG NPKHISPPSG KTTISLLTHH WNPQELIQEE
     GDSKCGYGGG RRRKYDETED GIGLQNIRDS SLQADDLNHE ISNKLLKHFS PRLHTTFRRI
     EVTEASETNS DRHLPEEGDS DAEPELPSGP RPRRMSELNL KQKKSPMPVA TSFFVFSHTN
     PFRCWCYFIA NNNIFNNGIF VCIMLSSVAL ACEDPIDSKA DLNEVLKYFD YVFTGIFTAE
     IILKMVAYGV ILHKGSFCRS LFNLLDLLVV AVSLISILGN SDGFSVVKIL RVLRVLRPLR
     AINRAKGLKH VVQCVIVAIS TIGNIFVITT LLQFMFACIG VQLFKGRLYS CTDESKSTRE
     ECKGDFYTIP NDGIGQPRIK QREWVNNDFN YDNVLNAMLT LFVVATFEGW PALLYKSIDS
     WKEGMGPKYD ARPAVALFYF IYIIVIAFFM MNIFVGFVIV TFQEQGEQEY KNCELDKNQR
     QCVEYALKAK PTRRYIPKNP WQYKAWFVVN STYFEYFMLV LILLNTVCLA VQHYQQDENL
     TRILNYMNFV FTTLFTIEMI FKLIAFKPRG YISDPWNIFD FLVVIGSIVD ILLSKIDTSF
     SINFFRLFRV LRLVKLLSRG EGIRTLLWTF IKSFQALPYV ALLIVLLFFI YAVIGMQVFG
     KVKTIDGEQI NRNNNFQTFI QSVLLLFRCA TGESWQEVML AAASGKECDD RSDWNGTGTA
     TPEDKFTCGS DFSYTYFLTF YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKT
     VWSEYDPEAK GRIKHLNVVK LLRRIQPPLG FGKLCPQRMA CRKLVTMNMP LNSDGTVMFN
     ATLFALIRTS LNIKTEGNID QANEELRAVI KKIWKRTSIK LLDQIAPPAG SNDITVGKFY
     NATYLI
//
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