ID H2YX19_CIOSA Unreviewed; 2215 AA.
AC H2YX19;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ABC transporter domain-containing protein {ECO:0000259|PROSITE:PS50893};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000009880.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000009880.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSCSAVT00000010000.1; ENSCSAVP00000009880.1; ENSCSAVG00000005809.1.
DR GeneTree; ENSGT00940000154658; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 692..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 831..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1314..1335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1614..1635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1655..1681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1693..1712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1724..1750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1811..1834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 911..1149
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1873..2109
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2215 AA; 248195 MW; 15AC47CD1AEB0D8B CRC64;
MFWQQLRLLL WKNFILRKRH PIRTIIEVLW PIFLFAILVA IRKTQPIDTK GECHYPGRAM
PSAGIYPWFK SMFCDLENPC FSKEVPSEVP GQINSPGNAN SAWMGNAVSS ILMLLQQNTS
ITQNQNQIIK DLQAVQNFTA QLPFNSTRVG FSTVIQNSTA YTEFVTNNLS IPYDVVKALL
NSTVSPAQVN ILPLSLQQRL VVCSPPVLQT IFQLPSTSQL NITAVSNELC NLTDYQLTLL
GNYTTSSLET SSQWSNYQST INTTVFNRIS WGKFLFQCTY LCVPMIYCLL FFPSDNAVMM
MTMQCMDFVI PRQYKTVLNL LEKHRNSLGF CGHSDTKTKV SQLFTNGNQD FTSKIALLAL
PLSRDGFNST VFCQNLTAIL ESNNQFKLLW DVLKPLLLGK IPYSPDTPLV RSIIKRANAT
FETIAIVKEF GQMWQSTNGP ALHNFLENGS TVHILDTIPL STLSTLLNIS VSNLEQVRTF
LSNDYNATDG VITWKDLYYQ LNSGILFITN VLGCFELNKF EGYQSEQRLV DASLSRTKNK
TLWGAIVFMN PTENSEVLPK IVKYKIRQDA GSVTKTTSIQ SFSWEPDAEA DYTSNKMAYY
NGGFLFLQDM VEQAIIEGVV PEPFVGRYMQ EFPYPCYTYD EFLEYLSALL SLLMTLAWIY
SVCIIIKNIV YEKEQRLKEV MKMMGLSNGV HWVAWFINSF SLMFLSILLL ILVLKVGDVT
PYSNMFIVLI WLCCFAIATI SQCFLISCFF SRANLAAACG GIIYFLMYIP YNMTYAWQDE
MTISTKLVAC LLSTVAFGYG AGYISQYEMS GDGIQFSNWN TSPDPSDHMN FLLSMLMMLV
DAAIYLILTW YIEAVFPGQY GVPRPWNFFL QRSYWCGSTD DLRSNESYSA YNQDDPSIKL
ETEPSHLKLG VSMHNLSKKK IHKIFSSNGK VAVDGLSLNF YENQITAFLG HNGAGKTTTM
SMLTGLFPPS GGTASIYKKD IQTDMDSIRH ELGFCPQHNV LFGDLTVLEH LQLYAGLKGS
SSGKTQSESE TNNMLQDVGL PHKKHEMTRH LSGGMKRKLS VAIAFVGGSK CVVLDEPTAG
VDPYARRGIW DLLLHYKQNR TIVLSTHHMD EADLLGDRIA IISHGKLKCC GSSLFLKSCF
GVGYYLTLVT DDKEISPGES PLTEKAVLPV NKKSSILAQM VTDTISGVKL YEDNGREITF
VLPYSAQTDG SYAKLFEKLN NANANYGLTD TSLEEIFLNV AEHSKDDGKE ENTKFHEDQT
SEMIDHSISD DVSMDDTSQG IGSYKVEGNK LIRQQFLSLF VKRFHHARRN TKGIVAQVIV
PAAFVALALT FALIIPQTKE YPSLELQPWM YGDTNTFFSN DNSSSNITSS ASNALINDPS
IGMRCVKDYS VYNYDKKFLT CNAVANSTKR ALSQNVTSNE TIECSCTDKQ TRVLLAECPV
GTGGAPTPRI ITRTSNPMYN MTQRNLSDWL VKTVGETLTY FINIIHRFKQ SRFGGLSFGA
QYYNTIGSML TPLLQFSQSN SNFTLNINPN SSNNIQSVVQ RLVRTDNSKV WFDNSGWHSM
PTWLNIMNNA ALRSSLPPSA DPTEYGIAAF NHPLNFTETE VDLAAFTQSA TDTIISISVI
FALAFVPASF VLFLIEEKVS KAKHLQFVSG VNQFIYWIAN FTWDMLNYSI PAIIVIIIFL
CFQTDAYVSA ANLPCLVCLL FLYGFAITPM MYPASFYFEV PSTAYVVLTC INLFIGINTS
IATFILEVIL LDDPNLTEVN NALKIIFLAF PQYCLGRALI DMAINQAYAD AYASFGKLNN
PFDYDLVGRN LLAMAIEGVV FFILTVLIQY RFFIKHNKIE DLSKIPRRTG MEDDDVTAEK
KRLLEEGDIT DILQIKNLTK VYKKLGSKKR LLAVDRMSIG VPRGECFGLL GVNGAGKTTT
FKMLTGDIAP TAGDATICHQ SILDNIREVQ QNTGYCPQFE ALNQLLTGRE HLEFYAKLRG
VPPEDIDRVA QWGIMKFGLK MYADKSAGTY SGGNKRKLSA AIAFIGCPPV VFLDEPTAGM
DPLSRRFLWS RISEVVSNGR CIVLTSHSME ECEALCSRLA IMVNGSFKCI GSPQHLKNRY
GEGYTITVKV SDGTENLENV QAFIQEAFPN CVVKESHSSM IMVPLEDMNL SFLFDEMERN
KSRLSIEDYS VNQTTLDEVF VSFAKLQTDG FEHEYGLPCA ETVTEIDEGQ DSVVL
//
