ID H2YYU9_CIOSA Unreviewed; 2705 AA.
AC H2YYU9;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010510.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000010510.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR Ensembl; ENSCSAVT00000010637.1; ENSCSAVP00000010510.1; ENSCSAVG00000006185.1.
DR GeneTree; ENSGT00940000167397; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF4; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000007875};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2035..2056
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2239..2263
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2290..2309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2321..2348
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2368..2396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2417..2439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2538..2561
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 116..170
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 235..291
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 933..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2669..2703
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1003..1019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2705 AA; 308802 MW; 600CC137041E9342 CRC64;
QAVMASSFLH IGDVISLFAE GSGPNSVCGF ISTLGLVDDR CVVQPDAGNL QNPPKKFRDC
LFKICPMNRY NAQKQFWKTL KSGATRIADA VIMKRLQESA GVEKDQNERE NQKLLGQVVK
YGSVVQLLHL KSNKYLTVNK RLPALLEKNA MRVSLDPDGN EGSWFYIQLF YKLRSTGDNV
VIGDKVVIMP VNAGQPLHAS KCELADNPGC KEVNSVSCNT SWKIVLFMTW EDDRKDVLKG
GDVVRMFHAE QEKFLTCDEY RRSLHVFLRT TGRMSATSAT SSKALWEIEV VQKDPCQGGA
GHWNNLFRFK HLASGNYLAA KVTIFILDNT SENGGSSEKE SSRSRNRAPP VGMSFCLVAT
AESSSVSSIF ELDPTSFTKS DALVPSNSYV RLKHLCTDTW VHSTMIPIDK EEDRPVMLKI
GTCKYKEDKE AFAIVNVNVE EVRDLDFAND SSKVLADCAK DMETKQITVN ERRFVIKLLE
DLIFFVARQP RGAMDALDVM VVDPDRERQK LLREQNILKQ VFKILQAPFK DSGDGALLHL
DELRDKKNVH YQHMLKLCYR LLRHSTQDYR KNQCSVVAYM SLFHLSCEYI AKSFGLMQQQ
IGHDILAEDT ITALLHNNRK LLEQHITGTE IETFVALVRK NREPRFLDYL ADLCVTNKQA
IPKTQELICR NILALKNKDI LIETKLGIDE SGEEVALLSY GDGKAVEKSI RHLAQSNILD
DKTVLTYYRH QLDLFSKMCL DRQYLAINPI SEELTIPIIL KCMADTQLPY DLRASFVQLM
LHMHVDKEPQ EQVIPVQYAR LWSGIPNQIN INDYDNDVGR HGFEKFVPTM QFVEEYLNSF
VNNAWIFKNK KENKLTFEVV NLARHLIYFG FYSFADLLSL NRTLLQILDC VNGVPTNLFN
GRIADTGSGV DAVSRGVGNI GLLVSTMTLG GTLPPQSGGN ETTPQNPSSP SIHMNSHDEY
VLETKLKIIE ILHFILDVRL DYRISLLSIF KREFDENNGR QRELPSSADS STQSEGSCAP
PPINLGVISA KSEGIFDGSL ESSDLDLDED GGRMFLRVLL NLVMHDYPPL VSGALQLLFR
HFSQRQEVLG AFKNVQLLVT KDEHENYTEI KRNLDQLRLL VEKSELWVWK GKSQNTTSNP
REIRDESVDY APVLDANRPS IKSSSLKNYN TIKEILRKLA GLCTDASSEK PCKEQQRLLR
NMGAHGVVLD LLQISYERGT DEEMQRVMTQ AHRFLQLFCK GNPQNQALLH KNLNLFMTPG
LLEAETMQAI FQDNVALCKE VTHGVIQHFV HCIESHGRRT EYLRFLQAII KSEGKVHIRR
CQDMVMAELV NTQAGEEVLL FYNDRASFTT FIKLMEDYAR DCALQHERWL VIFAHTATEG
KNVYTEIKCH SLLPLDDIVQ VVTHESCIPE VKNAYVNFLN HCYVDTEVEM KEIYSSNHIW
RLFDDFMEDM ERQCRVTVRS KEADDHIRKL QHYLATTVMD IITMFFSSPF SDATTVIQTR
QTTYNQLLRS IAMLNQSSHL LPQFKPKLED TMKKMGEVAK DRKIAIPGAL DTEVNGALNR
PTVLEVIKKF RSLRTSGSWR EGEPTLGQSY RDIIECLQDS VAVLDAQLRP LVQAELSVLV
DILHRPELLF PVDTDARKQC EGGGFISKLI KHTEKLLEDR EDKLCVKVLQ TLREMMTVHI
SFNKSNSVYN DHIWEEVNCI FLLCCSLDSP TQWCHPNIHS ATVMQYLLAR SCTYMFYYFS
PVLMYRQNLK MKRAIIKHPI IRSIFRKTEL TLEEVQCHLK KEGATDLVIN LIIGNYSEKI
FHESVLLGIA LLEGGNNDNQ TSFYNQLLQD QGSEKFFEVF HEKIEAAQLE LKNSSTVNAS
DDRHDEEKTL SPVISIMKPI LRFLQLLCEN HNAHLQNYLR TQNNKNSYNL VCDTLKFLDC
ICGSTTGGLG LLGLYINEHN VELINQTLES LTEYCQGPCH DNQNAIASHE SNGIDIIIAL
ILNDIIPLGK QRMDLVMQLK NNASKLLLAI MESRHDSENA ERILRNINHT QLVSVYMGLH
LWVLLWCIWS LTCMWLSQGQ RMAEEEELEG VVGDSQLDMT GDGSPRAVGH NIYILAHQLA
RHNTSLAQSL KPDNSLTGTE ALHYYKKHTA QIEIVRSDRT MEQIVFPVPH VCSYLTKETM
DRVWNTTDRD EQGSKVGSFF KQTEDMYREM VWQKKLRGQF VVEQEGYGFD SYPVVLHQFS
GYNTYIAEYT SLYWFSRHIS LWSTISTNFI IIINILVALF YPFKTLDYKG KLLPHIVTPP
SPAWNDKAQL ILWPSMLVSL AAITNPLAVR CFTLCIMVKT IFWIGVQNAL LILGVLNLLN
RFIYLLSFLG NKGMKDQGVM KVLMETQFII HVGHIFFCFI GLFWDELFYS ILFFDLIYGE
ETLLNVIRSV TRNVRSLLLT AMLALILVYL FSIVGYLFLK QDFKVSVSPR CSSTSPERLQ
SLRDKLDKEL RNTQVCRQDD GYLCDGGDSV EENHCESLLM CIITTLNEGL RNGGGIGDIL
RKPSQSGILF MGRVVYDLLF FFILIIIVLN LIFGVIIDTF ADLRSEKQQK DDVLRNTCFI
CGLERKSFDN KTVSFETHVK EEHNMWHYLY FVVLVKVKDP TEFTGPESYV YNQVKERLLE
WFPRMQAMSL AADDDAVENN DVRGLLVQLE ANSNLVKSLS AQLQDLQDQV TEQRRKQQRL
NIINP
//
