ID H2YYX2_CIOSA Unreviewed; 1842 AA.
AC H2YYX2;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0000259|PROSITE:PS51456};
OS Ciona savignyi (Pacific transparent sea squirt).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000010533.1, ECO:0000313|Proteomes:UP000007875};
RN [1] {ECO:0000313|Proteomes:UP000007875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAVP00000010533.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSCSAVT00000010660.1; ENSCSAVP00000010533.1; ENSCSAVG00000006193.1.
DR GeneTree; ENSGT00940000163461; -.
DR HOGENOM; CLU_000192_8_0_1; -.
DR Proteomes; UP000007875; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 6.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 2.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF67; MYOSIN-6; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 3.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT DOMAIN 17..702
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 579..601
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1105..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1792..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 763..1079
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1808..1842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 110..117
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1842 AA; 213773 MW; 375655D95346AB47 CRC64;
MTVKEDDLQE MNPPRYEKCE DMAGMTFLNE ASVLNNLRSR YESFMIYTYS GLFCVTVNPY
KMLPVYAPYV ISAYKGKRRT EMPPHLYSIA DNAYTEMLMN RENQSMLITG ESGAGKTVNT
KKVIQYFALV AAFGGSQDDG KGTLEDQIVQ CNPAMEAFGN AKTVRNDNSS RFGKFIRIHF
GSTGLLASGD IEHYLLEKSR VIYQQEGERN YHIFYQIISG SKPELIDQLL VTKDPYDYRS
ISQGVVSVPS MDDGAELLLT DDAFRVLGFN QEEISGIYRL MAGIMHQQNM KFKNKQREEQ
AEPDGTEDAD KVAYLFGLNS ADFIKYLCHP RVKVGNEYVT KGHYGIGALS KGLFGRHFDW
LVKLINQTLS TKLPRSFFIG VLDIAGFEIF DSNSFEQLCI NFTNEKLQQF FNHHMFVLEQ
EEYKKEGIDW VFIDFGMDLA ACIELIEKPL GIMSILEEEC MFPKASDDTF KEKLYQNHLG
KSKAFGKPVK KTKYEAHFEL YHYAGTVQYN ICGWLEKNKD PLNNSVVDLY KKASMKLMQT
IWEGYVSPEE AASGGGGKGG KRKKGGSFMT VSSLHRQSLN ALMTNLRSTA PHFVRCLIPN
ERKCPGEMDS HLVLHQLRCN GVLEGIRICR KGFPNRVPYG DFKQRYRILN PNAAPEGQFM
DSKKSSEKLL GSIDINHEAY KLGHTKVFFR AGMIGKLEEM RDNKLSSIFK LIQARMRGML
MRREYQKMIE RRQACRIIQS NLRAFFGMAN CEWMKLMFKI KPLLKTAESA KELEMEKEFA
ETKVNLEKET KRRKELEEMQ VSFIQEKNDL VMQLQAQQDQ IDDGEDRCDQ LIKTKVELDG
KIKELTERLE DEEELNNELV SKKRKLEDEC SELKKDIDDL EITLAKVEKE KHATENKLKN
LQEELATQDE QIAKLQKEKK ALQEAHQQTL DDLQSEEDKV NSLTKQKAKL EQQVDDLEAS
LEQEKKLRME LERTKRKLEG DLRLTQETVM DLENDKQRLE EKLKKQEFEY SQLATKLEDE
QALVSQLQKK IKELQARIEE LEEEIEAERA ARAKVEKQRA DLSRELEELS ERLEEAGGAT
AAQIELNKRR EAEFAKLRRE LEESNLGHEA TVSTLRKKHA DTSSEMSEQI RELENELDSE
QRRNGESVKS QRKIERRLKE VSYQGEEDKK NLTRIQDLVD KLQIKVKTYK RQAEEAEREI
TTSSTRSSLV QSRSSLDAFR VLGFNQEEIS GIYRLMAGIM HQQNMKFKNK QREEQAEPDG
TEGMELSTCE LLCVKCDTEL LITLNLTNRA TALNNFASTL QTRSSNTCIE LIEKVMSAQK
KVSRPSVTVY QLVNTVILKC SCKRRWRKRR QTQEGRFLYD SCRIIQSNLR AFFGMANCEW
MKLMFKIKPL LKTAESAKEL EEMEKEFAET KVNLEKETKR RKELEEMQVS FIQEKNDLVM
QLQAQQDQID DGEDRCDQLI KTKVELDGKI KELTERLEDE EELNNELVSK KRKLEDECSE
LKKDIDDLEI TLAKVEKEKH ATENKVSQQY SNLKNLQEEL ATQDEQIAKL QKEKKALQEA
HQQTLDDLQS EEDKVNSLTK QKAKLEQQVD DLEASLEQEK KLRMELERTK RKLEGDLRLT
QETVMDLEND KQRLEEKLKK QEFEYSQLAT KLEDEQALVS QLQKKIKELQ ARIEELEEEL
EAERAARAKV EKQRADLSRE LEELSERLEE AVSTLRKKHA DTSSEMSEQI RELENELDSE
QRRNGESVKS QRKIERRLKE VSYQGEEDKK NLTRIQDLVD KLQIKVKTYK RQAEEAEEQA
NTNLSKYRKL QHELDDAEER AEMAESQLNK MRSKARDTKG EK
//
