ID   H2Z796_CIOSA            Unreviewed;      1199 AA.
AC   H2Z796;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
OS   Ciona savignyi (Pacific transparent sea squirt).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC   Cionidae; Ciona.
OX   NCBI_TaxID=51511 {ECO:0000313|Ensembl:ENSCSAVP00000013458.1, ECO:0000313|Proteomes:UP000007875};
RN   [1] {ECO:0000313|Proteomes:UP000007875}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Birren B., Nusbaum C., Abebe A., Abouelleil A., Adekoya E., Ait-zahra M.,
RA   Allen N., Allen T., An P., Anderson M., Anderson S., Arachchi H.,
RA   Armbruster J., Bachantsang P., Baldwin J., Barry A., Bayul T.,
RA   Blitshsteyn B., Bloom T., Blye J., Boguslavskiy L., Borowsky M.,
RA   Boukhgalter B., Brunache A., Butler J., Calixte N., Calvo S., Camarata J.,
RA   Campo K., Chang J., Cheshatsang Y., Citroen M., Collymore A., Considine T.,
RA   Cook A., Cooke P., Corum B., Cuomo C., David R., Dawoe T., Degray S.,
RA   Dodge S., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N., Dupes A.,
RA   Elkins T., Engels R., Erickson J., Farina A., Faro S., Ferreira P.,
RA   Fischer H., Fitzgerald M., Foley K., Gage D., Galagan J., Gearin G.,
RA   Gnerre S., Gnirke A., Goyette A., Graham J., Grandbois E., Gyaltsen K.,
RA   Hafez N., Hagopian D., Hagos B., Hall J., Hatcher B., Heller A.,
RA   Higgins H., Honan T., Horn A., Houde N., Hughes L., Hulme W., Husby E.,
RA   Iliev I., Jaffe D., Jones C., Kamal M., Kamat A., Kamvysselis M.,
RA   Karlsson E., Kells C., Kieu A., Kisner P., Kodira C., Kulbokas E.,
RA   Labutti K., Lama D., Landers T., Leger J., Levine S., Lewis D., Lewis T.,
RA   Lindblad-toh K., Liu X., Lokyitsang T., Lokyitsang Y., Lucien O., Lui A.,
RA   Ma L.J., Mabbitt R., Macdonald J., Maclean C., Major J., Manning J.,
RA   Marabella R., Maru K., Matthews C., Mauceli E., Mccarthy M., Mcdonough S.,
RA   Mcghee T., Meldrim J., Meneus L., Mesirov J., Mihalev A., Mihova T.,
RA   Mikkelsen T., Mlenga V., Moru K., Mozes J., Mulrain L., Munson G.,
RA   Naylor J., Newes C., Nguyen C., Nguyen N., Nguyen T., Nicol R., Nielsen C.,
RA   Nizzari M., Norbu C., Norbu N., O'donnell P., Okoawo O., O'leary S.,
RA   Omotosho B., O'neill K., Osman S., Parker S., Perrin D., Phunkhang P.,
RA   Piqani B., Purcell S., Rachupka T., Ramasamy U., Rameau R., Ray V.,
RA   Raymond C., Retta R., Richardson S., Rise C., Rodriguez J., Rogers J.,
RA   Rogov P., Rutman M., Schupbach R., Seaman C., Settipalli S., Sharpe T.,
RA   Sheridan J., Sherpa N., Shi J., Smirnov S., Smith C., Sougnez C.,
RA   Spencer B., Stalker J., Stange-thomann N., Stavropoulos S., Stetson K.,
RA   Stone C., Stone S., Stubbs M., Talamas J., Tchuinga P., Tenzing P.,
RA   Tesfaye S., Theodore J., Thoulutsang Y., Topham K., Towey S., Tsamla T.,
RA   Tsomo N., Vallee D., Vassiliev H., Venkataraman V., Vinson J., Vo A.,
RA   Wade C., Wang S., Wangchuk T., Wangdi T., Whittaker C., Wilkinson J.,
RA   Wu Y., Wyman D., Yadav S., Yang S., Yang X., Yeager S., Yee E., Young G.,
RA   Zainoun J., Zembeck L., Zimmer A., Zody M., Lander E.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAVP00000013458.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR005719}.
CC   -!- SIMILARITY: Belongs to the SMC family. SMC4 subfamily.
CC       {ECO:0000256|ARBA:ARBA00006005}.
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DR   AlphaFoldDB; H2Z796; -.
DR   Ensembl; ENSCSAVT00000013614.1; ENSCSAVP00000013458.1; ENSCSAVG00000007900.1.
DR   GeneTree; ENSGT00900000141094; -.
DR   Proteomes; UP000007875; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR   Gene3D; 1.20.1060.20; -; 1.
DR   Gene3D; 3.30.70.1620; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003395; RecF/RecN/SMC_N.
DR   InterPro; IPR024704; SMC.
DR   InterPro; IPR010935; SMC_hinge.
DR   InterPro; IPR036277; SMC_hinge_sf.
DR   PANTHER; PTHR18937:SF172; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR   PANTHER; PTHR18937; STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER; 1.
DR   Pfam; PF06470; SMC_hinge; 1.
DR   Pfam; PF02463; SMC_N; 1.
DR   PIRSF; PIRSF005719; SMC; 2.
DR   SMART; SM00968; SMC_hinge; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF75553; Smc hinge domain; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007875}.
FT   DOMAIN          531..648
FT                   /note="SMC hinge"
FT                   /evidence="ECO:0000259|SMART:SM00968"
FT   COILED          185..212
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          252..406
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          432..500
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          767..822
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          849..905
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          935..1022
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1199 AA;  136264 MW;  15F7106C07D6FA69 CRC64;
     EPRLIITHIV NYNFKSYAGK KVLGPFHKSF TAIIGPNGSG KSNVIDSMLF VFGYRANKIR
     SKKLSVLIHN SENHKDATSC TVEVHFEKIV DVVRRDTCGY CTVPDSKFSV SRTARKDSTS
     QYFIGQRKVQ FKEVAALLQN NGIDLNHNRF LILQGEVEQI AMMHPKSQTN HGDGMLEYLE
     DIIGSSRYKD AIEKLNKEIE VLDEERKDKL SRVKVVEKDK DQLEPVRNEA IAFLKKKNER
     NVLENKKTQF YVNNLSKENE SSREKVEEIR AKVAESEQEL IEVREKKKEK AKSSKERVVA
     ALTEKRDEMR ELEKQNVKVF EDRKHRKGKI KELTKKLERE RKKIVDLEKL PEKHEEEISE
     LTEERDELGN RKKEIDDSLK AAMHSLKQET QELQDQKEEQ EKLLLGEVKY VNEAKQQLDI
     ASVELGLFAN KLTSAENAVE RCREQLRAAV DAEKTAKRKL AELNAKGAKN LEKEVKLQEL
     EKLSSDERRL ESQLRESLST LMEAKHSAQA NRSRGKVISF LMQLKNTGKV KGIYGRLGDL
     GAIDARYDVA ISSCCPALEN VLVDSIETAR ACVEQLKRND VGQATFIALD KVNYDTIIET
     GYSIVPDTSL PRLVDLIQAK EPRFHVAFYH ALRDTLVADD LAIATKVAYD RKRRWRVVTL
     QGELIDTAGT MSGGGNRVSK GRMGSNISTE TTPAELNAME EKKNNFEEKH QQVCVSPIKT
     VFPQTKLLCN SVSSVKIPLQ KCFLKKNSVS KQNSSIAVFH PQVRERRAQC EQELGEKREE
     LRNTASQTKL LEHDARAQQA LVAELKQRMP QLERELHEAQ PDPVQHKALQ DKVKKLTKGI
     DCICMLCSYE AASRKTDEIE KKKSELNSEI SRIQDAKLKP LRDKLEDAKT RIDEMSKKIT
     KLKTTFVGPI LDIIHLHAML TLLSHRNHSK CEKSIESTDA ELNENVEAVE RLEEEWKKLE
     VDGAAVLEVG RMVQLLVLQA LGEAEEESGR LGDALQEQQE ELKKLEKSEM ALAEAHKRMK
     QNQEVLCADS NSRGEKIEHL REKLPGYLEL NLIGLVGEYL GLNMVGLVGE YLGLNMVGLV
     GEYLGLNMVG LVGEYLGVRP PKKSWKTIRH LSGGEKTLSS LALVFALHYY RPTPLYVMDE
     IDAALDFKNV TIIAHYIKKR TRNAQFIIIS LRNNMFEIAD RLVGIYKTDN CTKSATIEP
//